| Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ... Human molecular genetics 15 (18), 2743-2751, 2006 | 470 | 2006 |
| A chaperone pathway in protein disaggregation: Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104 AG Cashikar, M Duennwald, SL Lindquist Journal of Biological Chemistry 280 (25), 23869-23875, 2005 | 377 | 2005 |
| The Hsp70/Hsp90 chaperone machinery in neurodegenerative diseases RE Lackie, A Maciejewski, VG Ostapchenko, J Marques-Lopes, WY Choy, ... Frontiers in neuroscience 11, 257764, 2017 | 359 | 2017 |
| Flanking sequences profoundly alter polyglutamine toxicity in yeast ML Duennwald, S Jagadish, PJ Muchowski, S Lindquist Proceedings of the National Academy of Sciences 103 (29), 11045-11050, 2006 | 351 | 2006 |
| Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity ML Duennwald, S Lindquist Genes & development 22 (23), 3308-3319, 2008 | 350 | 2008 |
| Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody DW Colby, YJ Chu, JP Cassady, M Duennwald, H Zazulak, JM Webster, ... Proceedings of the National Academy of Sciences 101 (51), 17616-17621, 2004 | 236 | 2004 |
| Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans ML Duennwald, AL Echeverria, J Shorter PLoS biology 10 (6), e1001346, 2012 | 207 | 2012 |
| Chaperone-dependent amyloid assembly protects cells from prion toxicity PM Douglas, S Treusch, HY Ren, R Halfmann, ML Duennwald, ... Proceedings of the National Academy of Sciences 105 (20), 7206-7211, 2008 | 199 | 2008 |
| A network of protein interactions determines polyglutamine toxicity ML Duennwald, S Jagadish, F Giorgini, PJ Muchowski, S Lindquist Proceedings of the National Academy of Sciences 103 (29), 11051-11056, 2006 | 174 | 2006 |
| Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease V Ngo, ML Duennwald Antioxidants 11 (12), 2345, 2022 | 124 | 2022 |
| A synergistic small-molecule combination directly eradicates diverse prion strain structures BE Roberts, ML Duennwald, H Wang, C Chung, NP Lopreiato, ... Nature chemical biology 5 (12), 936-946, 2009 | 115 | 2009 |
| Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum M Dunnwald, A Varshavsky, N Johnsson Molecular Biology of the Cell 10 (2), 329-344, 1999 | 109 | 1999 |
| Direct and selective elimination of specific prions and amyloids by 4, 5-dianilinophthalimide and analogs H Wang, ML Duennwald, BE Roberts, LM Rozeboom, YL Zhang, ... Proceedings of the National Academy of Sciences 105 (20), 7159-7164, 2008 | 84 | 2008 |
| Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin SM Chafekar, ML Duennwald PloS one 7 (5), e37929, 2012 | 82 | 2012 |
| Sec62p, a component of the endoplasmic reticulum protein translocation machinery, contains multiple binding sites for the Sec-complex S Wittke, M Dunnwald, N Johnsson Molecular biology of the cell 11 (11), 3859-3871, 2000 | 72 | 2000 |
| Relationships between fungal community composition in decomposing leaf litter and home‐field advantage effects GF Veen, BL Snoek, T Bakx‐Schotman, DA Wardle, WH van der Putten Functional Ecology 33 (8), 1524-1535, 2019 | 68 | 2019 |
| Recognition of a Subset of Signal Sequences by Ssh1p, a Sec61p-related Protein in the Membrane of Endoplasmic Reticulum of Yeast Saccharomyces cerevisiae S Wittke, M Dunnwald, M Albertsen, N Johnsson Molecular biology of the cell 13 (7), 2223-2232, 2002 | 68 | 2002 |
| Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 L Riva, M Koeva, F Yildirim, L Pirhaji, D Dinesh, T Mazor, ML Duennwald, ... Journal of Huntington's disease 1 (1), 33-45, 2012 | 59 | 2012 |
| Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease BS Rutledge, WY Choy, ML Duennwald Journal of Biological Chemistry 298 (5), 2022 | 53 | 2022 |
| Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation SM Chafekar, S Wisén, AD Thompson, AL Echeverria, GM Walter, ... ACS chemical biology 7 (9), 1556-1564, 2012 | 43 | 2012 |
