| Milestones of Lynch syndrome: 1895–2015 HT Lynch, CL Snyder, TG Shaw, CD Heinen, MP Hitchins Nature Reviews Cancer 15 (3), 181-194, 2015 | 921 | 2015 |
| Inheritance of a Cancer-Associated MLH1 Germ-Line Epimutation MP Hitchins, JJL Wong, G Suthers, CM Suter, DIK Martin, NJ Hawkins, ... New England Journal of Medicine 356 (7), 697-705, 2007 | 498 | 2007 |
| MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer M Hitchins, R Williams, K Cheong, N Halani, VAP Lin, D Packham, S Ku, ... Gastroenterology 129 (5), 1392-1399, 2005 | 225 | 2005 |
| Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5′ UTR MP Hitchins, RW Rapkins, CT Kwok, S Srivastava, JJL Wong, ... Cancer cell 20 (2), 200-213, 2011 | 214 | 2011 |
| Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark P Arnaud, D Monk, M Hitchins, E Gordon, W Dean, CV Beechey, J Peters, ... Human molecular genetics 12 (9), 1005-1019, 2003 | 181 | 2003 |
| Duplication of 7p11. 2-p13, including GRB10, in Silver-Russell syndrome D Monk, EL Wakeling, V Proud, M Hitchins, SN Abu-Amero, P Stanier, ... The American Journal of Human Genetics 66 (1), 36-46, 2000 | 171 | 2000 |
| Constitutional (germline) MLH1 epimutation as an aetiological mechanism for hereditary non-polyposis colorectal cancer MP Hitchins, RL Ward Journal of medical genetics 46 (12), 793-802, 2009 | 158 | 2009 |
| Silver-Russell syndrome: a dissection of the genetic aetiology and candidate chromosomal regions MP Hitchins, P Stanier, MA Preece, GE Moore Journal of medical genetics 38 (12), 810-819, 2001 | 142 | 2001 |
| Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2 S Haraldsdottir, T Rafnar, WL Frankel, S Einarsdottir, A Sigurdsson, ... Nature communications 8 (1), 14755, 2017 | 137 | 2017 |
| Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry RL Ward, T Dobbins, NM Lindor, RW Rapkins, MP Hitchins Genetics in medicine 15 (1), 25-35, 2013 | 111 | 2013 |
| De novo constitutional MLH1 epimutations confer early‐onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on … A Goel, TP Nguyen, HCE Leung, T Nagasaka, J Rhees, E Hotchkiss, ... International Journal of Cancer 128 (4), 869-878, 2011 | 110 | 2011 |
| Constitutional epimutation as a mechanism for cancer causality and heritability? MP Hitchins Nature Reviews Cancer 15 (10), 625-634, 2015 | 107 | 2015 |
| Chromosome 7p disruptions in Silver Russell syndrome: delineating an imprinted candidate gene region. D Monk, L Bentley, M Hitchins, RA Myler, J Clayton-Smith, S Ismail, ... Human genetics 111, 376-387, 2002 | 102 | 2002 |
| MGMT methylation is associated primarily with the germline C> T SNP (rs16906252) in colorectal cancer and normal colonic mucosa NJ Hawkins, JHF Lee, JJL Wong, CT Kwok, RL Ward, MP Hitchins Modern Pathology 22 (12), 1588-1599, 2009 | 87 | 2009 |
| The role of epigenetics in Lynch syndrome MP Hitchins Familial cancer 12 (2), 189-205, 2013 | 86 | 2013 |
| Epigenetic Inactivation of a Cluster of Genes Flanking MLH1 in Microsatellite-Unstable Colorectal Cancer MP Hitchins, VA Lin, A Buckle, K Cheong, N Halani, S Ku, CT Kwok, ... Cancer research 67 (19), 9107-9116, 2007 | 85 | 2007 |
| Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32 K Nakabayashi, L Bentley, MP Hitchins, K Mitsuya, M Meguro, ... Human Molecular Genetics 11 (15), 1743-1756, 2002 | 85 | 2002 |
| Maternal repression of the human GRB10 gene in the developing central nervous system; evaluation of the role for GRB10 in Silver-Russell syndrome MP Hitchins, D Monk, GM Bell, Z Ali, MA Preece, P Stanier, GE Moore European Journal of Human Genetics 9 (2), 82-90, 2001 | 82 | 2001 |
| Epimutations and cancer predisposition: importance and mechanisms LB Hesson, MP Hitchins, RL Ward Current opinion in genetics & development 20 (3), 290-298, 2010 | 76 | 2010 |
| The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide RW Rapkins, F Wang, HTN Nguyen, TF Cloughesy, A Lai, W Ha, ... Neuro-oncology 17 (12), 1589-1598, 2015 | 73 | 2015 |
