| HDAC2 negatively regulates memory formation and synaptic plasticity JS Guan, SJ Haggarty, E Giacometti, JH Dannenberg, N Joseph, J Gao, ... Nature 459 (7243), 55-60, 2009 | 1772 | 2009 |
| Chemical phylogenetics of histone deacetylases JE Bradner, N West, ML Grachan, EF Greenberg, SJ Haggarty, T Warnow, ... Nature chemical biology 6 (3), 238-243, 2010 | 842 | 2010 |
| Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma L Santo, T Hideshima, AL Kung, JC Tseng, D Tamang, M Yang, M Jarpe, ... Blood, The Journal of the American Society of Hematology 119 (11), 2579-2589, 2012 | 667 | 2012 |
| Treatment of obesity with celastrol J Liu, J Lee, MAS Hernandez, R Mazitschek, U Ozcan Cell 161 (5), 999-1011, 2015 | 662 | 2015 |
| Bioorthogonal turn-on probes for imaging small molecules inside living cells NK Devaraj, S Hilderbrand, R Upadhyay, R Mazitschek, R Weissleder Angewandte Chemie (International ed. in English) 49 (16), 2869, 2010 | 475 | 2010 |
| Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response MS Sundrud, SB Koralov, M Feuerer, DP Calado, AEH Kozhaya, ... Science 324 (5932), 1334-1338, 2009 | 474 | 2009 |
| Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase TL Keller, D Zocco, MS Sundrud, M Hendrick, M Edenius, J Yum, YJ Kim, ... Nature chemical biology 8 (3), 311-317, 2012 | 397 | 2012 |
| HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions ADA Tran, TP Marmo, AA Salam, S Che, E Finkelstein, R Kabarriti, ... Journal of cell science 120 (8), 1469-1479, 2007 | 337 | 2007 |
| Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity D Kim, CL Frank, MM Dobbin, RK Tsunemoto, W Tu, PL Peng, JS Guan, ... Neuron 60 (5), 803-817, 2008 | 330 | 2008 |
| Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity A Schuetz, J Min, A Allali-Hassani, M Schapira, M Shuen, P Loppnau, ... Journal of Biological Chemistry 283 (17), 11355-11363, 2008 | 328 | 2008 |
| Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3+ T-regulatory cells EF de Zoeten, L Wang, K Butler, UH Beier, T Akimova, H Sai, JE Bradner, ... Molecular and cellular biology, 2011 | 283 | 2011 |
| Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6 Y Zilberman, C Ballestrem, L Carramusa, R Mazitschek, S Khochbin, ... Journal of cell science 122 (19), 3531-3541, 2009 | 277 | 2009 |
| High-throughput screen for novel antimicrobials using a whole animal infection model TI Moy, AL Conery, J Larkins-Ford, G Wu, R Mazitschek, G Casadei, ... ACS chemical biology 4 (7), 527-533, 2009 | 258 | 2009 |
| Small molecules as inhibitors of cyclin‐dependent kinases A Huwe, R Mazitschek, A Giannis Angewandte Chemie International Edition 42 (19), 2122-2138, 2003 | 235 | 2003 |
| Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease JE Bradner, R Mak, SK Tanguturi, R Mazitschek, SJ Haggarty, K Ross, ... Proceedings of the National Academy of Sciences 107 (28), 12617-12622, 2010 | 230 | 2010 |
| Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor M Bazzaro, Z Lin, A Santillan, MK Lee, MC Wang, KC Chan, RE Bristow, ... Clinical cancer research 14 (22), 7340-7347, 2008 | 211 | 2008 |
| Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability J Jochems, J Boulden, BG Lee, JA Blendy, M Jarpe, R Mazitschek, ... Neuropsychopharmacology 39 (2), 389-400, 2014 | 210 | 2014 |
| Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation AB Mak, AML Nixon, S Kittanakom, JM Stewart, GI Chen, J Curak, ... Cell reports 2 (4), 951-963, 2012 | 205 | 2012 |
| Histone deacetylase 3 as a novel therapeutic target in multiple myeloma J Minami, R Suzuki, R Mazitschek, G Gorgun, B Ghosh, D Cirstea, Y Hu, ... Leukemia 28 (3), 680-689, 2014 | 163 | 2014 |
| A robust small-molecule microarray platform for screening cell lysates JE Bradner, OM McPherson, R Mazitschek, D Barnes-Seeman, JP Shen, ... Chemistry & biology 13 (5), 493-504, 2006 | 159 | 2006 |
James BradnerNovartis Institutes for BioMedical Research在 novartis.com 的电子邮件经过验证
