A comparison of three fluorophores for the detection of amyloid fibers and prefibrillar oligomeric assemblies. ThT (thioflavin T); ANS (1-anilinonaphthalene-8-sulfonic acid … ND Younan, JH Viles Biochemistry 54 (28), 4297-4306, 2015 | 187 | 2015 |
The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers ND Younan, CJ Sarell, P Davies, DR Brown, JH Viles The FASEB Journal 27 (5), 1847, 2013 | 101 | 2013 |
Copper (II)-induced secondary structure changes and reduced folding stability of the prion protein ND Younan, M Klewpatinond, P Davies, AV Ruban, DR Brown, JH Viles Journal of molecular biology 410 (3), 369-382, 2011 | 71 | 2011 |
Cu2+ accentuates distinct misfolding of Aβ(1–40) and Aβ(1–42) peptides, and potentiates membrane disruption CJ Matheou, ND Younan, JH Viles Biochemical Journal 466 (2), 233-242, 2015 | 66 | 2015 |
Methionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathway ND Younan, RC Nadal, P Davies, DR Brown, JH Viles Journal of Biological Chemistry 287 (34), 28263-28275, 2012 | 57 | 2012 |
Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease ND Younan, KF Chen, RS Rose, DC Crowther, JH Viles Journal of Biological Chemistry 293 (34), 13090-13099, 2018 | 44 | 2018 |
N‐Terminally Truncated Amyloid‐β(11–40/42) Cofibrillizes with its Full‐Length Counterpart: Implications for Alzheimer's Disease JD Barritt, ND Younan, JH Viles Angewandte Chemie 129 (33), 9948-9951, 2017 | 34 | 2017 |
The rapid exchange of Zinc2+ enables trace levels to profoundly influence amyloid-β misfolding and dominates assembly outcomes in Cu2+/Zn2+ mixtures CJ Matheou, ND Younan, JH Viles Journal of Molecular Biology 428 (14), 2832-2846, 2016 | 25 | 2016 |
Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: The N-terminal region of S2 facilitates self-association CB Otara, CE Jones, ND Younan, JH Viles, MR Elphick Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844 (2), 358-365, 2014 | 6 | 2014 |
Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides S1 and S2 CE Jones, CB Otara, ND Younan, JH Viles, MR Elphick Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844 (10), 1842-1850, 2014 | 5 | 2014 |
The cellular prion protein traps Alzheimer’s Aß in an oligomeric form and disassembles amyloid fibers ND Younan, CJ Sarell, P Davies, DR Brown, JH Viles | 1 | |
The influence of copper (II) ions on the structure and stability of the prion protein and its interaction with the amyloid-beta peptides. ND Younan Queen Mary University of London, 2012 | | 2012 |