| Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9 B Shen, KM Brown, TD Lee, LD Sibley MBio 5 (3), 10.1128/mbio. 01114-14, 2014 | 477 | 2014 |
| Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes MD Hall, KA Telma, KE Chang, TD Lee, JP Madigan, JR Lloyd, ... Cancer research 74 (14), 3913-3922, 2014 | 378 | 2014 |
| Discovery and optimization of potent, cell-active pyrazole-based inhibitors of lactate dehydrogenase (LDH) G Rai, KR Brimacombe, BT Mott, DJ Urban, X Hu, SM Yang, TD Lee, ... Journal of medicinal chemistry 60 (22), 9184-9204, 2017 | 125 | 2017 |
| Dynamic imaging of LDH inhibition in tumors reveals rapid in vivo metabolic rewiring and vulnerability to combination therapy N Oshima, R Ishida, S Kishimoto, K Beebe, JR Brender, K Yamamoto, ... Cell reports 30 (6), 1798-1810. e4, 2020 | 107 | 2020 |
| Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays DJ Urban, NJ Martinez, MI Davis, KR Brimacombe, DM Cheff, TD Lee, ... Scientific reports 7 (1), 12758, 2017 | 86 | 2017 |
| Functional Analysis of Rhomboid Proteases during Toxoplasma Invasion B Shen, JS Buguliskis, TD Lee, LD Sibley MBio 5 (5), 10.1128/mbio. 01795-14, 2014 | 70 | 2014 |
| Structural characterization of degrader-induced ternary complexes using hydrogen–deuterium exchange mass spectrometry and computational modeling: Implications for structure … SJ Eron, H Huang, RV Agafonov, ME Fitzgerald, J Patel, RE Michael, ... ACS Chemical Biology 16 (11), 2228-2243, 2021 | 45 | 2021 |
| Pyrazole-based lactate dehydrogenase inhibitors with optimized cell activity and pharmacokinetic properties G Rai, DJ Urban, BT Mott, X Hu, SM Yang, GA Benavides, MS Johnson, ... Journal of medicinal chemistry 63 (19), 10984-11011, 2020 | 39 | 2020 |
| Canvass: A crowd-sourced, natural-product screening library for exploring biological space SE Kearney, G Zahoránszky-Kőhalmi, KR Brimacombe, MJ Henderson, ... ACS central science 4 (12), 1727-1741, 2018 | 38 | 2018 |
| Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors JM Rohde, KR Brimacombe, L Liu, ME Pacold, A Yasgar, DM Cheff, ... Bioorganic & medicinal chemistry 26 (8), 1727-1739, 2018 | 37 | 2018 |
| A high-throughput screen of a library of therapeutics identifies cytotoxic substrates of P-glycoprotein TD Lee, OW Lee, KR Brimacombe, L Chen, R Guha, S Lusvarghi, ... Molecular Pharmacology 96 (5), 629-640, 2019 | 24 | 2019 |
| Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer JM Rohde, S Karavadhi, R Pragani, L Liu, Y Fang, W Zhang, A McIver, ... Journal of medicinal chemistry 64 (8), 4913-4946, 2021 | 21 | 2021 |
| Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter RW Robey, AN Robinson, F Ali-Rahmani, LM Huff, S Lusvarghi, S Vahedi, ... Scientific Reports 11 (1), 24150, 2021 | 20 | 2021 |
| Pan-cancer proteogenomics expands the landscape of therapeutic targets SR Savage, X Yi, JT Lei, B Wen, H Zhao, Y Liao, EJ Jaehnig, LK Somes, ... Cell 187 (16), 4389-4407. e15, 2024 | 16 | 2024 |
| Cytotoxic profiling of annotated and diverse chemical libraries using quantitative high-throughput screening OW Lee, S Austin, M Gamma, DM Cheff, TD Lee, KM Wilson, J Johnson, ... SLAS DISCOVERY: Advancing Life Sciences R&D 25 (1), 9-20, 2020 | 15 | 2020 |
| SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers L Shi, W Shen, MI Davis, K Kong, P Vu, SK Saha, R Adil, J Kreuzer, ... Nature Cancer 4 (3), 365-381, 2023 | 13 | 2023 |
| Keeping it clean: the cell culture quality control experience at the national center for advancing translational sciences JS Roth, TD Lee, DM Cheff, ML Gosztyla, RR Asawa, C Danchik, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (5), 491-497, 2020 | 7 | 2020 |
| Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions KM Flickinger, KM Wilson, NJ Rossiter, AL Hunger, PV Vishwasrao, ... Science Advances 10 (40), eadq3591, 2024 | 4 | 2024 |
| Optimization of ether and aniline based inhibitors of lactate dehydrogenase PP Christov, K Kim, S Jana, IM Romaine, G Rai, BT Mott, AA Allweil, ... Bioorganic & medicinal chemistry letters 41, 127974, 2021 | 2 | 2021 |
