| Antiaggregatory activity in human platelets of potent antagonists of the P2Y1 receptor M Cattaneo, A Lecchi, M Ohno, BV Joshi, P Besada, S Tchilibon, ... Biochemical pharmacology 68 (10), 1995-2002, 2004 | 116 | 2004 |
| Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists H Ko, RL Carter, L Cosyn, R Petrelli, S de Castro, P Besada, Y Zhou, ... Bioorganic & medicinal chemistry 16 (12), 6319-6332, 2008 | 99 | 2008 |
| Structure−Activity Relationships of Uridine 5‘-Diphosphate Analogues at the Human P2Y6 Receptor P Besada, DH Shin, S Costanzi, H Ko, C Mathé, J Gagneron, G Gosselin, ... Journal of medicinal chemistry 49 (18), 5532-5543, 2006 | 85 | 2006 |
| Agonists and antagonists for P2 receptors KA Jacobson, S Costanzi, BV Joshi, P Besada, DH Shin, H Ko, AA Ivanov, ... Purinergic Signalling in Neuron–Glia Interactions: Novartis Foundation …, 2006 | 72 | 2006 |
| Molecular recognition at purine and pyrimidine nucleotide (P2) receptors KA Jacobson, S Costanzi, M Ohno, BV Joshi, P Besada, B Xu, S Tchilibon Current topics in medicinal chemistry 4 (8), 805-819, 2004 | 72 | 2004 |
| Molecular Modeling of the Human P2Y2 Receptor and Design of a Selective Agonist, 2‘-Amino-2‘-deoxy-2-thiouridine 5‘-Triphosphate AA Ivanov, H Ko, L Cosyn, S Maddileti, P Besada, I Fricks, S Costanzi, ... Journal of medicinal chemistry 50 (6), 1166-1176, 2007 | 68 | 2007 |
| Phthalazin-1 (2H)-one as a remarkable scaffold in drug discovery N Vila, P Besada, T Costas, MC Costas-Lago, C Teran European journal of medicinal chemistry 97, 462-482, 2015 | 64 | 2015 |
| New pyridazinone derivatives with vasorelaxant and platelet antiaggregatory activities T Costas, P Besada, A Piras, L Acevedo, M Yañez, F Orallo, R Laguna, ... Bioorganic & medicinal chemistry letters 20 (22), 6624-6627, 2010 | 62 | 2010 |
| Structure activity and molecular modeling analyses of ribose-and base-modified uridine 5′-triphosphate analogues at the human P2Y2 and P2Y4 receptors KA Jacobson, S Costanzi, AA Ivanov, S Tchilibon, P Besada, ZG Gao, ... Biochemical pharmacology 71 (4), 540-549, 2006 | 58 | 2006 |
| Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species Z Wang, CW Do, MY Avila, K Peterson-Yantorno, RA Stone, ZG Gao, ... Experimental eye research 90 (1), 146-154, 2010 | 52 | 2010 |
| Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality P Besada, L Mamedova, CJ Thomas, S Costanzi, KA Jacobson Organic & biomolecular chemistry 3 (10), 2016-2025, 2005 | 50 | 2005 |
| Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation LK Mamedova, R Wang, P Besada, BT Liang, KA Jacobson Pharmacological research 58 (3-4), 232-239, 2008 | 47 | 2008 |
| Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors MC Costas-Lago, P Besada, F Rodríguez-Enríquez, D Vina, S Vilar, ... European Journal of Medicinal Chemistry 139, 1-11, 2017 | 45 | 2017 |
| BCUT descriptors to predicting affinity toward A3 adenosine receptors MP González, C Terán, M Teijeira, P Besada, MJ González-Moa Bioorganic & medicinal chemistry letters 15 (15), 3491-3495, 2005 | 38 | 2005 |
| Novel coumarin-pyridazine hybrids as selective MAO-B inhibitors for the Parkinson’s disease therapy F Rodriguez-Enriquez, MC Costas-Lago, P Besada, M Alonso-Pena, ... Bioorganic Chemistry 104, 104203, 2020 | 32 | 2020 |
| A radial distribution function approach to predict A2B agonist effect of adenosine analogues MP González, C Terán, Y Fall, M Teijeira, P Besada Bioorganic & medicinal chemistry 13 (3), 601-608, 2005 | 29 | 2005 |
| New platelet aggregation inhibitors based on pyridazinone moiety T Costas, MC Costas-Lago, N Vila, P Besada, E Cano, C Terán European Journal of Medicinal Chemistry 94, 113-122, 2015 | 28 | 2015 |
| Synthesis, biological evaluation and molecular modeling studies of phthalazin-1 (2 H)-one derivatives as novel cholinesterase inhibitors N Vila, P Besada, D Viña, M Sturlese, S Moro, C Terán RSC advances 6 (52), 46170-46185, 2016 | 26 | 2016 |
| Geometry, topology, and atom-weights assembly descriptors to predicting A1 adenosine receptors agonists MP González, C Terán, M Teijeira, P Besada Bioorganic & medicinal chemistry letters 15 (10), 2641-2645, 2005 | 25 | 2005 |
| Intramolecular oxidative palladium-catalyzed amination involving double C–H functionalization of unactivated olefins G Broggini, T Borelli, S Giofré, A Mazza Synthesis 49 (13), 2803-2818, 2017 | 24 | 2017 |
