| Autosis is a Na+, K+-ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia Y Liu, S Shoji-Kawata, RM Sumpter, Y Wei, V Ginet, L Zhang, B Posner, ... Proceedings of the National Academy of Sciences 110 (51), 20364-20371, 2013 | 609 | 2013 |
| QSAR modeling of the blood–brain barrier permeability for diverse organic compounds L Zhang, H Zhu, TI Oprea, A Golbraikh, A Tropsha Pharmaceutical research 25 (8), 1902-1914, 2008 | 223 | 2008 |
| Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl … A Fensome, CM Ambler, E Arnold, ME Banker, MF Brown, J Chrencik, ... Journal of medicinal chemistry 61 (19), 8597-8612, 2018 | 132 | 2018 |
| Use of in Vitro HTS-Derived Concentration–Response Data as Biological Descriptors Improves the Accuracy of QSAR Models of in Vivo Toxicity A Sedykh, H Zhu, H Tang, L Zhang, A Richard, I Rusyn, A Tropsha Environmental health perspectives 119 (3), 364-370, 2011 | 128 | 2011 |
| Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening L Zhang, D Fourches, A Sedykh, H Zhu, A Golbraikh, S Ekins, J Clark, ... Journal of chemical information and modeling 53 (2), 475-492, 2013 | 108 | 2013 |
| Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR-and structure-based virtual screening approaches L Zhang, A Sedykh, A Tripathi, H Zhu, A Afantitis, VD Mouchlis, ... Toxicology and applied pharmacology 272 (1), 67-76, 2013 | 102 | 2013 |
| Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators M Boehm, K Beaumont, R Jones, AS Kalgutkar, L Zhang, K Atkinson, ... Journal of Medicinal Chemistry 60 (23), 9653-9663, 2017 | 64 | 2017 |
| Design, optimization, and study of small molecules that target tau pre-mRNA and affect splicing JL Chen, P Zhang, M Abe, H Aikawa, L Zhang, AJ Frank, T Zembryski, ... Journal of the American Chemical Society 142 (19), 8706-8727, 2020 | 51 | 2020 |
| Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation X Huang, KCD Roet, L Zhang, A Brault, AP Berg, AB Jefferson, ... Cell reports 35 (10), 109224, 2021 | 40 | 2021 |
| Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers B Sprague, Q Shi, MT Kim, L Zhang, A Sedykh, E Ichiishi, H Tokuda, ... Journal of computer-aided molecular design 28 (6), 631-646, 2014 | 35 | 2014 |
| Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents K Nakagawa-Goto, PC Wu, CY Lai, E Hamel, H Zhu, L Zhang, T Kozaka, ... Journal of medicinal chemistry 54 (5), 1244-1255, 2011 | 28 | 2011 |
| Monitoring the progression of structure–activity relationship information during lead optimization V Shanmugasundaram, L Zhang, S Kayastha, A de la Vega de León, ... Journal of medicinal chemistry 59 (9), 4235-4244, 2016 | 25 | 2016 |
| Deep understanding of structure–solubility relationship for a diverse set of organic compounds using matched molecular pairs L Zhang, H Zhu, A Mathiowetz, H Gao Bioorganic & medicinal chemistry 19 (19), 5763-5770, 2011 | 23 | 2011 |
| Genes differentially expressed in responsive and refractory acute leukemia Q Wei, Y Li, L Chen, L Zhang, X He, X Fu, K Ying, J Huang, Q Chen, Y Xie, ... Front Biosci 11, 977-982, 2006 | 19 | 2006 |
| Transcriptomic RNAseq drug screen in cerebrocortical cultures: toward novel neurogenetic disease therapies J Hadwen, S Schock, A Mears, R Yang, P Charron, L Zhang, HS Xi, ... Human molecular genetics 27 (18), 3206-3217, 2018 | 14 | 2018 |
| Amine promiscuity and toxicology analysis ECY Lee, G Steeno, AM Wassermann, L Zhang, F Shah, DA Price Bioorganic & medicinal chemistry letters 27 (3), 653-657, 2017 | 10 | 2017 |
| The identification of pivotal transcriptional factors mediating cell responses to drugs with drug-induced liver injury liabilities F Shah, A Medvedev, AM Wassermann, M Brodney, L Zhang, S Makarov, ... Toxicological Sciences 162 (1), 177-188, 2018 | 8 | 2018 |
| Computers instead of cells: computational modeling of chemical toxicity A SEDYKH Reducing, Refining and Replacing the Use of Animals in Toxicity Testing 19, 163, 2013 | 7* | 2013 |
| Methyl-and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof ME Schnute, AC Flick, P Jones, N Kaila, SR Mente, JD Trzupek, ... US Patent 9,670,201, 2017 | 5 | 2017 |
| Discovery of the TYK2 selective inhibitor PF-6826647 for the treatment of Crohn's disease, and other autoimmune conditions B Gerstenberger, E Arnold, ME Banker, M Brown, J Clark, A Dermenci, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | 3 | 2018 |
Hao ZhuProfessor of Biomedical Informatics and Genomics, Tulane University在 tulane.edu 的电子邮件经过验证
