| Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization TJ Smith, J Lou, IN Geren, CM Forsyth, R Tsai, SL Laporte, WH Tepp, ... Infection and immunity 73 (9), 5450-5457, 2005 | 333 | 2005 |
| Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin C Garcia-Rodriguez, R Levy, JW Arndt, CM Forsyth, A Razai, J Lou, ... Nature biotechnology 25 (1), 107-116, 2007 | 233 | 2007 |
| Molecular evolution of antibody affinity for sensitive detection of botulinum neurotoxin type A A Razai, C Garcia-Rodriguez, J Lou, IN Geren, CM Forsyth, Y Robles, ... Journal of molecular biology 351 (1), 158-169, 2005 | 182 | 2005 |
| Fine and domain-level epitope mapping of botulinum neurotoxin type A neutralizing antibodies by yeast surface display R Levy, CM Forsyth, SL LaPorte, IN Geren, LA Smith, JD Marks Journal of molecular biology 365 (1), 196-210, 2007 | 136 | 2007 |
| Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins JD Marks, P Amersdorfer US Patent 7,563,874, 2009 | 89* | 2009 |
| Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin C Garcia-Rodriguez, IN Geren, J Lou, F Conrad, C Forsyth, W Wen, ... Protein engineering, design & selection 24 (3), 321-331, 2011 | 84 | 2011 |
| Extraction and inhibition of enzymatic activity of botulinum neurotoxins/A1,/A2, and/A3 by a panel of monoclonal anti-BoNT/A antibodies SR Kalb, J Lou, C Garcia-Rodriguez, IN Geren, TJ Smith, H Moura, ... Plos one 4 (4), e5355, 2009 | 74 | 2009 |
| Affinity maturation of human botulinum neurotoxin antibodies by light chain shuffling via yeast mating J Lou, I Geren, C Garcia-Rodriguez, CM Forsyth, W Wen, K Knopp, ... Protein Engineering, Design & Selection 23 (4), 311-319, 2010 | 68 | 2010 |
| Recombinant anthrax toxin receptor-Fc fusion proteins produced in plants protect rabbits against inhalational anthrax KL Wycoff, A Belle, D Deppe, L Schaefer, JM Maclean, S Haase, ... Antimicrobial agents and chemotherapy 55 (1), 132-139, 2011 | 53 | 2011 |
| Molecular architecture of botulinum neurotoxin E revealed by single particle electron microscopy A Fischer, C Garcia-Rodriguez, I Geren, J Lou, JD Marks, T Nakagawa, ... Journal of Biological Chemistry 283 (7), 3997-4003, 2008 | 49 | 2008 |
| The use of Endopep-MS to detect multiple subtypes of botulinum neurotoxins A, B, E, and F SR Kalb, TJ Smith, H Moura, K Hill, J Lou, IN Geren, C Garcia-Rodriguez, ... International journal of mass spectrometry 278 (2-3), 101-108, 2008 | 46 | 2008 |
| A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype E subtypes C Garcia-Rodriguez, A Razai, IN Geren, J Lou, F Conrad, WH Wen, ... Toxins 10 (3), 105, 2018 | 36 | 2018 |
| Extraction and inhibition of enzymatic activity of botulinum neurotoxins/B1,/B2,/B3,/B4, and/B5 by a panel of monoclonal anti-BoNT/B antibodies SR Kalb, WI Santana, IN Geren, C Garcia-Rodriguez, J Lou, TJ Smith, ... BMC biochemistry 12, 1-11, 2011 | 34 | 2011 |
| Antibodies for botulinum neurotoxins JD Marks, MCG Rodriguez US Patent 9,243,057, 2016 | 30 | 2016 |
| Antibodies That Neutralize Botulinum Neurotoxins Marks, J D., Lou, Jianlong, Rodriguez, MC Garcia, Geren, I N. US Patent WO2010/014854 A2, 2010 | 25* | 2010 |
| Monoclonal antibodies that inhibit the proteolytic activity of botulinum neurotoxin serotype/B Y Fan, J Dong, J Lou, W Wen, F Conrad, IN Geren, C Garcia-Rodriguez, ... Toxins 7 (9), 3405-3423, 2015 | 23 | 2015 |
| Monoclonal antibodies targeting the alpha-exosite of botulinum neurotoxin serotype/A inhibit catalytic activity Y Fan, IN Geren, J Dong, J Lou, W Wen, F Conrad, TJ Smith, LA Smith, ... PLoS One 10 (8), e0135306, 2015 | 20 | 2015 |
| Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins JD Marks, I Geren, J Lou US Patent 7,700,738, 2010 | 20 | 2010 |
| Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins JD Marks, MC Garcia US Patent 9,902,780, 2018 | 14 | 2018 |
| Antibodies that neutralize botulinum neurotoxins JD Marks, IN Geren US Patent 10,308,708, 2019 | 13 | 2019 |
Robert W Siegel,Indiana University, Los Alamos, PNNL, Abbott Laboratories, Eli Lilly在 lilly.com 的电子邮件经过验证
