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William Gwynne
William Gwynne
Post-doctoral scientist at UToronto
在 utoronto.ca 的电子邮件经过验证 - 首页
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Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts
WD Gwynne, RM Hallett, A Girgis-Gabardo, B Bojovic, A Dvorkin-Gheva, ...
Oncotarget 8 (19), 32101, 2017
492017
CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment
M Seyfrid, WT Maich, MV Shaikh, N Tatari, D Upreti, D Piyasena, ...
Journal for immunotherapy of cancer 10 (1), 2022
462022
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma
WD Gwynne, Y Suk, S Custers, N Mikolajewicz, JK Chan, Z Zador, ...
Cancer Cell 40 (12), 1488-1502. e7, 2022
422022
Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer
RM Hallett, A Girgis-Gabardo, WD Gwynne, AO Giacomelli, JNP Bisson, ...
Oncotarget 7 (33), 53137, 2016
332016
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers
N Tatari, S Khan, J Livingstone, K Zhai, D Mckenna, V Ignatchenko, ...
Acta neuropathologica 144 (6), 1127-1142, 2022
232022
Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma
N Nawar, S Bukhari, AA Adile, Y Suk, P Manaswiyoungkul, K Toutah, ...
Journal of medicinal chemistry 65 (4), 3193-3217, 2022
222022
Antagonists of the serotonin receptor 5A target human breast tumor initiating cells
WD Gwynne, MS Shakeel, A Girgis-Gabardo, KH Kim, E Ford, ...
BMC cancer 20, 1-17, 2020
192020
The role of serotonin in breast cancer stem cells
WD Gwynne, MS Shakeel, A Girgis-Gabardo, JA Hassell
Molecules 26 (11), 3171, 2021
182021
Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells
WD Gwynne, MS Shakeel, J Wu, RM Hallett, A Girgis-Gabardo, ...
Cellular & molecular biology letters 24, 1-13, 2019
172019
Childhood medulloblastoma: an overview
Y Suk, WD Gwynne, I Burns, C Venugopal, SK Singh
Medulloblastoma: Methods and Protocols, 1-12, 2022
122022
Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence
D Bakhshinyan, AA Adile, J Liu, WD Gwynne, Y Suk, S Custers, I Burns, ...
Science Advances 7 (50), eabi5568, 2021
122021
The antiarrhythmic drug, dronedarone, demonstrates cytotoxic effects in breast cancer independent of thyroid hormone receptor Alpha 1 (THRα1) antagonism
MJ Elliott, KJ Jerzak, JG Cockburn, Z Safikhani, WD Gwynne, JA Hassell, ...
Scientific Reports 8 (1), 16562, 2018
122018
The C-terminus of Bienertia sinuspersici Toc159 contains essential elements for its targeting and anchorage to the chloroplast outer membrane
SC Lung, MD Smith, JK Weston, W Gwynne, N Secord, SDX Chuong
Frontiers in plant science 5, 722, 2014
122014
Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma
MM Kameda-Smith, H Zhu, EC Luo, Y Suk, A Xella, B Yee, C Chokshi, ...
Nature Communications 13 (1), 7506, 2022
72022
The road to CAR T-cell therapies for pediatric CNS tumors: obstacles and new avenues
I Burns, WD Gwynne, Y Suk, S Custers, I Chaudhry, C Venugopal, ...
Frontiers in Oncology, 99, 2022
32022
Protocol for mapping the metabolome and lipidome of medulloblastoma cells using liquid chromatography-mass spectrometry
JK Chan, WD Gwynne, BY Lieng, AT Quaile, C Venugopal, SK Singh, ...
STAR protocols 4 (4), 102736, 2023
22023
Dynamic profiling of medulloblastoma surfaceome
D Bakhshinyan, Y Suk, L Kuhlmann, AA Adile, V Ignatchenko, S Custers, ...
Acta neuropathologica communications 11 (1), 111, 2023
12023
De novo GTP synthesis is a metabolic vulnerability for the interception of brain metastases
AM Kieliszek, D Mobilio, BI Bassey-Archibong, JW Johnson, ...
Cell Reports Medicine 5 (10), 2024
2024
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