Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts WD Gwynne, RM Hallett, A Girgis-Gabardo, B Bojovic, A Dvorkin-Gheva, ... Oncotarget 8 (19), 32101, 2017 | 49 | 2017 |
CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment M Seyfrid, WT Maich, MV Shaikh, N Tatari, D Upreti, D Piyasena, ... Journal for immunotherapy of cancer 10 (1), 2022 | 46 | 2022 |
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma WD Gwynne, Y Suk, S Custers, N Mikolajewicz, JK Chan, Z Zador, ... Cancer Cell 40 (12), 1488-1502. e7, 2022 | 42 | 2022 |
Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer RM Hallett, A Girgis-Gabardo, WD Gwynne, AO Giacomelli, JNP Bisson, ... Oncotarget 7 (33), 53137, 2016 | 33 | 2016 |
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers N Tatari, S Khan, J Livingstone, K Zhai, D Mckenna, V Ignatchenko, ... Acta neuropathologica 144 (6), 1127-1142, 2022 | 23 | 2022 |
Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma N Nawar, S Bukhari, AA Adile, Y Suk, P Manaswiyoungkul, K Toutah, ... Journal of medicinal chemistry 65 (4), 3193-3217, 2022 | 22 | 2022 |
Antagonists of the serotonin receptor 5A target human breast tumor initiating cells WD Gwynne, MS Shakeel, A Girgis-Gabardo, KH Kim, E Ford, ... BMC cancer 20, 1-17, 2020 | 19 | 2020 |
The role of serotonin in breast cancer stem cells WD Gwynne, MS Shakeel, A Girgis-Gabardo, JA Hassell Molecules 26 (11), 3171, 2021 | 18 | 2021 |
Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells WD Gwynne, MS Shakeel, J Wu, RM Hallett, A Girgis-Gabardo, ... Cellular & molecular biology letters 24, 1-13, 2019 | 17 | 2019 |
Childhood medulloblastoma: an overview Y Suk, WD Gwynne, I Burns, C Venugopal, SK Singh Medulloblastoma: Methods and Protocols, 1-12, 2022 | 12 | 2022 |
Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence D Bakhshinyan, AA Adile, J Liu, WD Gwynne, Y Suk, S Custers, I Burns, ... Science Advances 7 (50), eabi5568, 2021 | 12 | 2021 |
The antiarrhythmic drug, dronedarone, demonstrates cytotoxic effects in breast cancer independent of thyroid hormone receptor Alpha 1 (THRα1) antagonism MJ Elliott, KJ Jerzak, JG Cockburn, Z Safikhani, WD Gwynne, JA Hassell, ... Scientific Reports 8 (1), 16562, 2018 | 12 | 2018 |
The C-terminus of Bienertia sinuspersici Toc159 contains essential elements for its targeting and anchorage to the chloroplast outer membrane SC Lung, MD Smith, JK Weston, W Gwynne, N Secord, SDX Chuong Frontiers in plant science 5, 722, 2014 | 12 | 2014 |
Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma MM Kameda-Smith, H Zhu, EC Luo, Y Suk, A Xella, B Yee, C Chokshi, ... Nature Communications 13 (1), 7506, 2022 | 7 | 2022 |
The road to CAR T-cell therapies for pediatric CNS tumors: obstacles and new avenues I Burns, WD Gwynne, Y Suk, S Custers, I Chaudhry, C Venugopal, ... Frontiers in Oncology, 99, 2022 | 3 | 2022 |
Protocol for mapping the metabolome and lipidome of medulloblastoma cells using liquid chromatography-mass spectrometry JK Chan, WD Gwynne, BY Lieng, AT Quaile, C Venugopal, SK Singh, ... STAR protocols 4 (4), 102736, 2023 | 2 | 2023 |
Dynamic profiling of medulloblastoma surfaceome D Bakhshinyan, Y Suk, L Kuhlmann, AA Adile, V Ignatchenko, S Custers, ... Acta neuropathologica communications 11 (1), 111, 2023 | 1 | 2023 |
De novo GTP synthesis is a metabolic vulnerability for the interception of brain metastases AM Kieliszek, D Mobilio, BI Bassey-Archibong, JW Johnson, ... Cell Reports Medicine 5 (10), 2024 | | 2024 |