| Mucus clearance as a primary innate defense mechanism for mammalian airways MR Knowles, RC Boucher The Journal of clinical investigation 109 (5), 571-577, 2002 | 1654 | 2002 |
| Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients D Worlitzsch, R Tarran, M Ulrich, U Schwab, A Cekici, KC Meyer, P Birrer, ... The Journal of clinical investigation 109 (3), 317-325, 2002 | 1608 | 2002 |
| SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract YJ Hou, K Okuda, CE Edwards, DR Martinez, T Asakura, KH Dinnon, ... Cell 182 (2), 429-446. e14, 2020 | 1503 | 2020 |
| Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease H Matsui, BR Grubb, R Tarran, SH Randell, JT Gatzy, CW Davis, ... Cell 95 (7), 1005-1015, 1998 | 1498 | 1998 |
| CFTR as a cAMP-dependent regulator of sodium channels MJ Stutts, CM Canessa, JC Olsen, M Hamrick, JA Cohn, BC Rossier, ... Science 269 (5225), 847-850, 1995 | 1381 | 1995 |
| An animal model for cystic fibrosis made by gene targeting JN Snouwaert, KK Brigman, AM Latour, NN Malouf, RC Boucher, ... Science 257 (5073), 1083-1088, 1992 | 1203 | 1992 |
| Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice M Mall, BR Grubb, JR Harkema, WK O'Neal, RC Boucher Nature medicine 10 (5), 487-493, 2004 | 1091 | 2004 |
| Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice E Hummler, P Barker, J Gatzy, F Beermann, C Verdumo, A Schmidt, ... Nature genetics 12 (3), 325-328, 1996 | 1050 | 1996 |
| SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo YJ Hou, S Chiba, P Halfmann, C Ehre, M Kuroda, KH Dinnon III, SR Leist, ... Science 370 (6523), 1464-1468, 2020 | 925 | 2020 |
| A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia B Button, LH Cai, C Ehre, M Kesimer, DB Hill, JK Sheehan, RC Boucher, ... Science 337 (6097), 937-941, 2012 | 871 | 2012 |
| Mucus clearance and lung function in cystic fibrosis with hypertonic saline SH Donaldson, WD Bennett, KL Zeman, MR Knowles, R Tarran, ... New England Journal of Medicine 354 (3), 241-250, 2006 | 857 | 2006 |
| New concepts of the pathogenesis of cystic fibrosis lung disease RC Boucher European Respiratory Journal 23 (1), 146-158, 2004 | 836 | 2004 |
| Submucosal glands are the predominant site of CFTR expression in the human bronchus JF Engelhardt, JR Yankaskas, SA Ernst, Y Yang, CR Marino, RC Boucher, ... Nature genetics 2 (3), 240-248, 1992 | 814 | 1992 |
| Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase. B Sarkadi, EM Price, RC Boucher, UA Germann, GA Scarborough Journal of Biological Chemistry 267 (7), 4854-4858, 1992 | 796 | 1992 |
| Muc5b is required for airway defence MG Roy, A Livraghi-Butrico, AA Fletcher, MM McElwee, SE Evans, ... Nature 505 (7483), 412-416, 2014 | 766 | 2014 |
| Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis M Knowles, J Gatzy, R Boucher New England Journal of Medicine 305 (25), 1489-1495, 1981 | 763 | 1981 |
| Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis SS Yoon, RF Hennigan, GM Hilliard, UA Ochsner, K Parvatiyar, ... Developmental cell 3 (4), 593-603, 2002 | 748 | 2002 |
| SARS-CoV-2 infection of the oral cavity and saliva N Huang, P Pérez, T Kato, Y Mikami, K Okuda, RC Gilmore, CD Conde, ... Nature medicine 27 (5), 892-903, 2021 | 724 | 2021 |
| A controlled study of adenoviral-vector–mediated gene transfer in the nasal epithelium of patients with cystic fibrosis MR Knowles, KW Hohneker, Z Zhou, JC Olsen, TL Noah, PC Hu, ... New England Journal of Medicine 333 (13), 823-831, 1995 | 719 | 1995 |
| Mechanisms of release of nucleotides and integration of their action as P2X-and P2Y-receptor activating molecules ER Lazarowski, RC Boucher, TK Harden Molecular pharmacology 64 (4), 785-795, 2003 | 705 | 2003 |
