T-cell activation by transitory neo-antigens derived from distinct microbial pathways AJ Corbett, SBG Eckle, RW Birkinshaw, L Liu, O Patel, J Mahony, Z Chen, ... Nature 509 (7500), 361-365, 2014 | 809 | 2014 |
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells R Reantragoon, AJ Corbett, IG Sakala, NA Gherardin, JB Furness, Z Chen, ... Journal of Experimental Medicine 210 (11), 2305-2320, 2013 | 607 | 2013 |
Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia P Blombery, MA Anderson, J Gong, R Thijssen, RW Birkinshaw, ... Cancer discovery 9 (3), 342-353, 2019 | 397 | 2019 |
Recognition of vitamin B metabolites by mucosal-associated invariant T cells O Patel, L Kjer-Nielsen, J Le Nours, SBG Eckle, R Birkinshaw, T Beddoe, ... Nature communications 4 (1), 2142, 2013 | 302 | 2013 |
A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells SBG Eckle, RW Birkinshaw, L Kostenko, AJ Corbett, HEG McWilliam, ... Journal of Experimental Medicine 211 (8), 1585-1600, 2014 | 291 | 2014 |
The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation RW Birkinshaw, PE Czabotar Seminars in cell & developmental biology 72, 152-162, 2017 | 259 | 2017 |
Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells AN Keller, SBG Eckle, W Xu, L Liu, VA Hughes, JYW Mak, BS Meehan, ... Nature immunology 18 (4), 402-411, 2017 | 221 | 2017 |
Diversity of T cells restricted by the MHC class I-related molecule MR1 facilitates differential antigen recognition NA Gherardin, AN Keller, RE Woolley, J Le Nours, DS Ritchie, PJ Neeson, ... Immunity 44 (1), 32-45, 2016 | 201 | 2016 |
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations RW Birkinshaw, J Gong, CS Luo, D Lio, CA White, MA Anderson, ... Nature communications 10 (1), 2385, 2019 | 179 | 2019 |
CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens A De Jong, TY Cheng, S Huang, S Gras, RW Birkinshaw, AG Kasmar, ... Nature immunology 15 (2), 177-185, 2014 | 174 | 2014 |
Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax P Blombery, ER Thompson, T Nguyen, RW Birkinshaw, J Gong, X Chen, ... Blood, The Journal of the American Society of Hematology 135 (10), 773-777, 2020 | 140 | 2020 |
αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands RW Birkinshaw, DG Pellicci, TY Cheng, AN Keller, M Sandoval-Romero, ... Nature immunology 16 (3), 258-266, 2015 | 138 | 2015 |
Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex W Wong, R Huang, S Menant, C Hong, JJ Sandow, RW Birkinshaw, ... Nature 565 (7737), 118-121, 2019 | 91 | 2019 |
Cutting edge: CD1a tetramers and dextramers identify human lipopeptide–specific T cells ex vivo AG Kasmar, I Van Rhijn, KG Magalhaes, DC Young, TY Cheng, ... The Journal of Immunology 191 (9), 4499-4503, 2013 | 86 | 2013 |
MAITs, MR1 and vitamin B metabolites RW Birkinshaw, L Kjer-Nielsen, SBG Eckle, J McCluskey, J Rossjohn Current opinion in immunology 26, 7-13, 2014 | 83 | 2014 |
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies EJ Petrie, RW Birkinshaw, A Koide, E Denbaum, JM Hildebrand, ... Proceedings of the National Academy of Sciences 117 (15), 8468-8475, 2020 | 67 | 2020 |
Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design JM Brouwer, P Lan, AD Cowan, JP Bernardini, RW Birkinshaw, ... Molecular cell 68 (4), 659-672. e9, 2017 | 61 | 2017 |
MR1 presentation of vitamin B-based metabolite ligands HEG McWilliam, RW Birkinshaw, JA Villadangos, J McCluskey, ... Current opinion in immunology 34, 28-34, 2015 | 55 | 2015 |
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues KA Davies, C Fitzgibbon, SN Young, SE Garnish, W Yeung, D Coursier, ... Nature communications 11 (1), 3060, 2020 | 51 | 2020 |
Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes J Healer, W Wong, JK Thompson, W He, RW Birkinshaw, K Miura, ... Cellular microbiology 21 (7), e13030, 2019 | 49 | 2019 |