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Patrick G. Holder, PhD
Patrick G. Holder, PhD
Principal Scientist, Genentech
在 gene.com 的电子邮件经过验证
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引用次数
引用次数
年份
Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system
EW Kovacs, JM Hooker, DW Romanini, PG Holder, KE Berry, MB Francis
Bioconjugate chemistry 18 (4), 1140-1147, 2007
2602007
Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes
PM Drake, AE Albers, J Baker, S Banas, RM Barfield, AS Bhat, ...
Bioconjugate chemistry 25 (7), 1331-1341, 2014
2412014
Engineering interferons and interleukins for cancer immunotherapy
PG Holder, SA Lim, CS Huang, P Sharma, YS Dagdas, B Bulutoglu, ...
Advanced drug delivery reviews 182, 114112, 2022
802022
Generating site-specifically modified proteins via a versatile and stable nucleophilic carbon ligation
R Kudirka, RM Barfield, J McFarland, AE Albers, GW de Hart, PM Drake, ...
Chemistry & biology 22 (2), 293-298, 2015
802015
Reconstitution of formylglycine-generating enzyme with copper (II) for aldehyde tag conversion
PG Holder, LC Jones, PM Drake, RM Barfield, S Banas, GW de Hart, ...
Journal of Biological Chemistry 290 (25), 15730-15745, 2015
782015
Integration of a Self‐Assembling Protein Scaffold with Water‐Soluble Single‐Walled Carbon Nanotubes
PG Holder, MB Francis
Angewandte Chemie International Edition 46 (23), 4370-4373, 2007
682007
Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper (II)
D York, J Baker, PG Holder, LC Jones, PM Drake, RM Barfield, GT Bleck, ...
BMC biotechnology 16, 1-11, 2016
532016
Photo-ribonucleotide reductase β2 by selective cysteine labeling with a radical phototrigger
AA Pizano, DA Lutterman, PG Holder, TS Teets, JA Stubbe, DG Nocera
Proceedings of the National Academy of Sciences, 2011
522011
Deciphering radical transport in the large subunit of class I ribonucleotide reductase
PG Holder, AA Pizano, BL Anderson, JA Stubbe, DG Nocera
Journal of the American Chemical Society 134 (2), 1172-1180, 2012
512012
Dramatic Thermal Stability of Virus− Polymer Conjugates in Hydrophobic Solvents
PG Holder, DT Finley, N Stephanopoulos, R Walton, DS Clark, ...
Langmuir, 2010
482010
Modulation of Y356 Photooxidation in E. coli Class Ia Ribonucleotide Reductase by Y731 Across the α22 Interface
AA Pizano, L Olshansky, PG Holder, JA Stubbe, DG Nocera
Journal of the American Chemical Society 135 (36), 13250-13253, 2013
172013
Chemically modified viral capsids as targeted delivery vectors for diagnostic and therapeutic agents
MB Francis, JM Hooker, EW Kovacs, DW Romanini, PG Holder, KE Berry
132007
Direct interfacial Y 731 oxidation in α 2 by a photoβ 2 subunit of E. coli class Ia ribonucleotide reductase
DY Song, AA Pizano, PG Holder, JA Stubbe, DG Nocera
Chemical science 6 (8), 4519-4524, 2015
112015
Complex PK-PD of an engineered IL-15/IL-15Rα–Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics
D Lu, R Yadav, P Holder, E Chiang, S Sanjabi, V Poon, M Bernett, ...
European Journal of Pharmaceutical Sciences 186, 106450, 2023
82023
High-Throughput Platform to Identify Antibody Conjugation Sites from Antibody–Drug Conjugate Libraries
S Yamazoe, JM Hogan, SM West, XA Deng, S Kotapati, X Shao, P Holder, ...
Bioconjugate Chemistry 31 (4), 1199-1208, 2020
52020
DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody–Drug Conjugate Modality
P Sivaprakasam, I McDonald, C Iwuagwu, NS Chowdari, KM Peese, ...
ACS Medicinal Chemistry Letters 12 (3), 404-412, 2021
32021
Technologies for Antibody‐Drug Conjugation
PG Holder, D Rabuka
Biosimilars of Monoclonal Antibodies: A Practical Guide to Manufacturing …, 2016
32016
Comprehensive UHPLC-and CE-based methods for engineered Cas9 characterization
J Camperi, G Console, L Zheng, N Stephens, M Montti, B Roper, M Zheng, ...
Talanta 252, 123780, 2023
22023
Antibody comprising a glutamine-containing light chain c-terminal extension, conjugates thereof, and methods and uses
P Strop, C Rao-Naik, X Deng, PO Sheppard, PG Holder, S Yamazoe
US Patent App. 17/297,796, 2022
22022
Ferritin as a natural protein scaffold: building a multivalent ferritin–Fab conjugate
W Shatz, Y Kalia, R Kelley, C Blanchette, P Holder, R Perozzo
MJH Life Sciences 37, 30–35-30–35, 2019
12019
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