| Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties GF Kelso, CM Porteous, CV Coulter, G Hughes, WK Porteous, ... Journal of Biological Chemistry 276 (7), 4588-4596, 2001 | 1313 | 2001 |
| Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells RM Jarvis, SM Hughes, EC Ledgerwood Free Radical Biology and Medicine 53 (7), 1522-1530, 2012 | 319 | 2012 |
| Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells JL Scarlett, PW Sheard, G Hughes, EC Ledgerwood, HH Ku, MP Murphy FEBS letters 475 (3), 267-272, 2000 | 303 | 2000 |
| TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1 SJ Jones, EC Ledgerwood, JB Prins, J Galbraith, DR Johnson, JS Pober, ... The Journal of Immunology 162 (2), 1042-1048, 1999 | 198 | 1999 |
| Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor κB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria … G Hughes, MP Murphy, EC Ledgerwood Biochemical journal 389 (1), 83-89, 2005 | 197 | 2005 |
| A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia IM Morison, EM Cramer Bordé, EJ Cheesman, PL Cheong, AJ Holyoake, ... Nature genetics 40 (4), 387-389, 2008 | 196 | 2008 |
| Recent advances in the molecular basis of TNF signal transduction. EC Ledgerwood, JS Pober, JR Bradley Laboratory Investigation; a Journal of Technical Methods and Pathology 79 (9 …, 1999 | 189 | 1999 |
| Prevention of mitochondrial oxidative damage using targeted antioxidants GF Kelso, CM Porteous, G Hughes, EC Ledgerwood, AM Gane, ... Annals of the New York Academy of Sciences 959 (1), 263-274, 2002 | 179 | 2002 |
| Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes CM Porteous, A Logan, C Evans, EC Ledgerwood, DK Menon, F Aigbirhio, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1800 (9), 1009-1017, 2010 | 137 | 2010 |
| Targeting the apoptosome for cancer therapy EC Ledgerwood, IM Morison Clinical cancer research 15 (2), 420-424, 2009 | 134 | 2009 |
| A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus D Westphal, EC Ledgerwood, MH Hibma, SB Fleming, EM Whelan, ... Journal of virology 81 (13), 7178-7188, 2007 | 109 | 2007 |
| Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis AG Cox, JM Pullar, G Hughes, EC Ledgerwood, MB Hampton Free Radical Biology and Medicine 44 (6), 1001-1009, 2008 | 96 | 2008 |
| Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences RAJ Smith, GF Kelso, FH Blaikie, CM Porteous, EC Ledgerwood, ... Biochemical Society Transactions 31 (6), 1295-1299, 2003 | 77 | 2003 |
| The Proapoptotic G41S Mutation to Human Cytochrome c Alters the Heme Electronic Structure and Increases the Electron Self-Exchange Rate MD Liptak, RD Fagerlund, EC Ledgerwood, SM Wilbanks, KL Bren Journal of the American Chemical Society 133 (5), 1153-1155, 2011 | 63 | 2011 |
| The role of peroxiredoxin 1 in redox sensing and transducing EC Ledgerwood, JWA Marshall, JF Weijman Archives of Biochemistry and Biophysics 617, 60-67, 2017 | 60 | 2017 |
| Tumor necrosis factor is delivered to mitochondria where a tumor necrosis factor-binding protein is localized. EC Ledgerwood, JB Prins, NA Bright, DR Johnson, K Wolfreys, JS Pober, ... Laboratory investigation; a journal of technical methods and pathology 78 …, 1998 | 57 | 1998 |
| The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax D Westphal, EC Ledgerwood, JDA Tyndall, MH Hibma, N Ueda, ... Apoptosis 14, 1317-1330, 2009 | 53 | 2009 |
| The N-terminal domains target TNF receptor-associated factor-2 to the nucleus and display transcriptional regulatory activity W Min, JR Bradley, JJ Galbraith, SJ Jones, EC Ledgerwood, JS Pober The Journal of Immunology 161 (1), 319-324, 1998 | 53 | 1998 |
| Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1 JF Weijman, A Kumar, SA Jamieson, CM King, TT Caradoc-Davies, ... Proceedings of the National Academy of Sciences 114 (11), E2096-E2105, 2017 | 45 | 2017 |
| Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination TM Josephs, MD Liptak, G Hughes, A Lo, RM Smith, SM Wilbanks, ... JBIC Journal of Biological Inorganic Chemistry 18, 289-297, 2013 | 44 | 2013 |
Michael P MurphyMRC Mitochondrial BIology Unit, University of Cambridge在 mrc-mbu.cam.ac.uk 的电子邮件经过验证
