Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax … A Llanos-Cuentas, M Casapia, R Chuquiyauri, JC Hinojosa, N Kerr, ... The Lancet Infectious Diseases 18 (8), 874-883, 2018 | 145 | 2018 |
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness BH Stokes, SK Dhingra, K Rubiano, S Mok, J Straimer, NF Gnädig, I Deni, ... Elife 10, e66277, 2021 | 129 | 2021 |
Mucus A McShane, J Bath, AM Jaramillo, C Ridley, AA Walsh, CM Evans, ... Current Biology 31 (15), R938-R945, 2021 | 76 | 2021 |
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the … J White, SK Dhingra, X Deng, F El Mazouni, MCS Lee, GA Afanador, ... ACS infectious diseases 5 (1), 90-101, 2018 | 52 | 2018 |
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance JM Murithi, C Pascal, J Bath, X Boulenc, NF Gnädig, CFA Pasaje, ... Science Translational Medicine 13 (603), eabg6013, 2021 | 33 | 2021 |
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series MJ Palmer, X Deng, S Watts, G Krilov, A Gerasyuto, S Kokkonda, ... Journal of Medicinal Chemistry 64 (9), 6085-6136, 2021 | 33 | 2021 |
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual … J Okombo, S Mok, T Qahash, T Yeo, J Bath, LM Orchard, E Owens, I Koo, ... PLoS pathogens 18 (10), e1010926, 2022 | 12 | 2022 |
Role of MUC5B during Group B Streptococcal Vaginal Colonization LR Burcham, JR Bath, CA Werlang, LM Lyon, N Liu, C Evans, K Ribbeck, ... Mbio 13 (2), e00039-22, 2022 | 9 | 2022 |
P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites BH Stokes, K Rubiano, SK Dhingra, S Mok, J Straimer, NF Gnädig, ... bioRxiv, 2021 | 4 | 2021 |
Identification of the Plasmodium falciparum acetyl-CoA synthetase as an emerging antiplasmodial drug target RL Summers, M Vanaerschot, JM Murithi, CF Pasaje, MR Luth, ... American Journal of Tropical Medicine and Hygiene 101 (5 Suppl. 1), 476-477, 2019 | 1 | 2019 |