Direct-to-biology accelerates PROTAC synthesis and the evaluation of linker effects on permeability and degradation CE Hendrick, JR Jorgensen, C Chaudhry, II Strambeanu, JF Brazeau, ... ACS medicinal chemistry letters 13 (7), 1182-1190, 2022 | 66 | 2022 |
Sea spray aerosol: where marine biology meets atmospheric chemistry JM Schiffer, LE Mael, KA Prather, RE Amaro, VH Grassian ACS central science 4 (12), 1617-1623, 2018 | 65 | 2018 |
Impacts of lipase enzyme on the surface properties of marine aerosols JM Schiffer, M Luo, AC Dommer, G Thoron, M Pendergraft, MV Santander, ... The Journal of Physical Chemistry Letters 9 (14), 3839-3849, 2018 | 28 | 2018 |
Improving the efficiency of ligand-binding protein design with molecular dynamics simulations EP Barros, JM Schiffer, A Vorobieva, J Dou, D Baker, RE Amaro Journal of chemical theory and computation 15 (10), 5703-5715, 2019 | 27 | 2019 |
Microplastics outreach program: a systems-thinking approach to teach high school students about the chemistry and impacts of plastics JM Schiffer, J Lyman, D Byrd, H Silverstein, MD Halls Journal of Chemical Education 97 (1), 137-142, 2019 | 21 | 2019 |
Conformational communication mediates the reset step in t6A biosynthesis A Luthra, N Paranagama, W Swinehart, S Bayooz, P Phan, V Quach, ... Nucleic acids research 47 (12), 6551-6567, 2019 | 21 | 2019 |
Protein cofactors are essential for high-affinity DNA binding by the nuclear factor κB RelA subunit MC Mulero, S Shahabi, MS Ko, JM Schiffer, DB Huang, VYF Wang, ... Biochemistry 57 (20), 2943-2957, 2018 | 20 | 2018 |
Mechanisms for benzene dissociation through the excited state of T4 lysozyme L99A mutant VA Feher, JM Schiffer, DJ Mermelstein, N Mih, LCT Pierce, ... Biophysical Journal 116 (2), 205-214, 2019 | 18 | 2019 |
Capturing invisible motions in the transition from ground to rare excited states of T4 lysozyme L99A JM Schiffer, VA Feher, RD Malmstrom, R Sida, RE Amaro Biophysical Journal 111 (8), 1631-1640, 2016 | 18 | 2016 |
How the ankyrin and SOCS box protein, ASB9, binds to creatine kinase D Balasubramaniam, J Schiffer, J Parnell, SP Mir, RE Amaro, EA Komives Biochemistry 54 (8), 1673-1680, 2015 | 17 | 2015 |
Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants D Avellaneda Matteo, GA Wells, LA Luna, AJ Grunseth, O Zagnitko, ... Biochemical Journal 475 (20), 3221-3238, 2018 | 14 | 2018 |
Model of the ankyrin and SOCS box protein, ASB9, E3 ligase reveals a mechanism for dynamic ubiquitin transfer JM Schiffer, RD Malmstrom, J Parnell, C Ramirez-Sarmiento, J Reyes, ... Structure 24 (8), 1248-1256, 2016 | 14 | 2016 |
Factors controlling the transfer of biogenic organic species from seawater to sea spray aerosol MV Santander, JM Schiffer, C Lee, JL Axson, MJ Tauber, KA Prather Scientific Reports 12 (1), 3580, 2022 | 11 | 2022 |
Cation-driven lipopolysaccharide morphological changes impact heterogeneous reactions of nitric acid with sea spray aerosol particles C Lee, AC Dommer, JM Schiffer, RE Amaro, VH Grassian, KA Prather The Journal of Physical Chemistry Letters 12 (20), 5023-5029, 2021 | 11 | 2021 |
Surfactant charge modulates structure and stability of lipase-embedded monolayers at marine-relevant aerosol surfaces M Luo, AC Dommer, JM Schiffer, DJ Rez, AR Mitchell, RE Amaro, ... Langmuir 35 (27), 9050-9060, 2019 | 11 | 2019 |
An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity LA Luna, Z Lesecq, KA White, A Hoang, DA Scott, O Zagnitko, AA Bobkov, ... Biochemical Journal 477 (16), 2999-3018, 2020 | 9 | 2020 |
Breaking the Glass Ceiling in Simulation and Modeling: Women in Pharmaceutical Discovery: Miniperspective KL Damm-Ganamet, RL DesJarlais, T Marrone, AY Shih, JM Schiffer, ... Journal of Medicinal Chemistry 63 (5), 1929-1936, 2020 | 5 | 2020 |
Water networks and correlated motions in mutant isocitrate dehydrogenase 1 (IDH1) are critical for allosteric inhibitor binding and activity JM Chambers, W Miller, G Quichocho, V Upadhye, DA Matteo, AA Bobkov, ... Biochemistry 59 (4), 479-490, 2019 | 3 | 2019 |
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms M Mealka, NA Sierra, D Avellaneda Matteo, E Albekioni, R Khoury, T Mai, ... Nature Communications 15 (1), 3785, 2024 | 1 | 2024 |
Monoacylglycerol lipase modulators MK Ameriks, BN Laforteza, S Ravula, JM Schiffer, BM Stenne US Patent App. 18/409,391, 2024 | | 2024 |