| Are 1, 4‐and 1, 5‐Disubstituted 1, 2, 3‐Triazoles Good Pharmacophoric Groups? A Massarotti, S Aprile, V Mercalli, E Del Grosso, G Grosa, G Sorba, ... ChemMedChem 9 (11), 2497-2508, 2014 | 152 | 2014 |
| Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues S Theeramunkong, A Caldarelli, A Massarotti, S Aprile, D Caprioglio, ... Journal of medicinal chemistry 54 (14), 4977-4986, 2011 | 105 | 2011 |
| In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes S Aprile, E Del Grosso, GC Tron, G Grosa Drug metabolism and disposition 35 (12), 2252-2261, 2007 | 105 | 2007 |
| Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis CC Campa, RL Silva, JP Margaria, T Pirali, MS Mattos, LR Kraemer, ... Nature communications 9 (1), 5232, 2018 | 87 | 2018 |
| Medicinal chemistry of isocyanides A Massarotti, F Brunelli, S Aprile, M Giustiniano, GC Tron Chemical Reviews 121 (17), 10742-10788, 2021 | 86 | 2021 |
| Identification of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors endowed with antiproliferative and antiinflammatory activity C Travelli, S Aprile, R Rahimian, AA Grolla, F Rogati, M Bertolotti, ... Journal of medicinal chemistry 60 (5), 1768-1792, 2017 | 58 | 2017 |
| Discovery of highly potent benzimidazole derivatives as indoleamine 2, 3-dioxygenase-1 (IDO1) inhibitors: from structure-based virtual screening to in vivo pharmacodynamic activity M Serafini, E Torre, S Aprile, ED Grosso, A Gesù, A Griglio, G Colombo, ... Journal of medicinal chemistry 63 (6), 3047-3065, 2020 | 52 | 2020 |
| Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4 S Aprile, E Del Grosso, G Grosa Drug metabolism and disposition 38 (7), 1141-1146, 2010 | 43 | 2010 |
| Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents U Galli, C Travelli, S Aprile, E Arrigoni, S Torretta, G Grosa, A Massarotti, ... Journal of medicinal chemistry 58 (3), 1345-1357, 2015 | 40 | 2015 |
| Targeting transient receptor potential vanilloid 1 (TRPV1) channel softly: The discovery of passerini adducts as a topical treatment for inflammatory skin disorders M Serafini, A Griglio, S Aprile, F Seiti, C Travelli, F Pattarino, G Grosa, ... Journal of medicinal chemistry 61 (10), 4436-4455, 2018 | 38 | 2018 |
| Biological effects of combined resveratrol and vitamin D3 on ovarian tissue F Uberti, V Morsanuto, S Aprile, S Ghirlanda, I Stoppa, A Cochis, G Grosa, ... Journal of ovarian research 10, 1-14, 2017 | 38 | 2017 |
| A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Anti‐Tubulin Agents R Zaninetti, SV Cortese, S Aprile, A Massarotti, PL Canonico, G Sorba, ... ChemMedChem 8 (4), 633-643, 2013 | 38 | 2013 |
| Poly‐L‐lactide acid‐modified scaffolds for osteoinduction and osteoconduction M Bosetti, L Fusaro, E Nicoli, A Borrone, S Aprile, M Cannas Journal of Biomedical Materials Research Part A 102 (10), 3531-3539, 2014 | 33 | 2014 |
| Pyrtriazoles, a novel class of store-operated calcium entry modulators: discovery, biological profiling, and in vivo proof-of-concept efficacy in acute pancreatitis B Riva, A Griglio, M Serafini, C Cordero-Sanchez, S Aprile, R Di Paola, ... Journal of medicinal chemistry 61 (21), 9756-9783, 2018 | 30 | 2018 |
| Efficient synthesis of diverse 5-thio-or 5-selenotriazoles: One-pot multicomponent reaction from elemental sulfur or selenium LL Zhang, YT Li, T Gao, SS Guo, B Yang, ZH Meng, QP Dai, ZB Xu, ... Synthesis 51 (22), 4170-4182, 2019 | 29 | 2019 |
| A versatile and sustainable multicomponent platform for the synthesis of protein degraders: proof-of-concept application to BRD4-degrading PROTACs IP Bhela, A Ranza, FC Balestrero, M Serafini, S Aprile, RMC Di Martino, ... Journal of Medicinal Chemistry 65 (22), 15282-15299, 2022 | 26 | 2022 |
| Synthesis, docking and biological evaluation of a novel class of imidazothiazoles as IDO1 inhibitors M Serafini, E Torre, S Aprile, A Massarotti, S Fallarini, T Pirali Molecules 24 (10), 1874, 2019 | 24 | 2019 |
| Identification of a potent phosphoinositide 3‐kinase pan inhibitor displaying a strategic carboxylic acid group and development of its prodrugs T Pirali, E Ciraolo, S Aprile, A Massarotti, A Berndt, A Griglio, M Serafini, ... ChemMedChem 12 (18), 1542-1554, 2017 | 22 | 2017 |
| Metabolic fate of the isocyanide moiety: are isocyanides pharmacophore groups neglected by medicinal chemists? U Galli, GC Tron, B Purghè, G Grosa, S Aprile Chemical research in toxicology 33 (4), 955-966, 2020 | 21 | 2020 |
| Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects M Bianchi, R Canavesi, S Aprile, G Grosa, E Del Grosso Journal of pharmaceutical and biomedical analysis 150, 248-257, 2018 | 20 | 2018 |
