| Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration LB Knudsen, PF Nielsen, PO Huusfeldt, NL Johansen, K Madsen, ... Journal of medicinal chemistry 43 (9), 1664-1669, 2000 | 940 | 2000 |
| The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss A Secher, J Jelsing, AF Baquero, J Hecksher-Sørensen, MA Cowley, ... The Journal of clinical investigation 124 (10), 4473-4488, 2014 | 847 | 2014 |
| Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide J Lau, P Bloch, L Schäffer, I Pettersson, J Spetzler, J Kofoed, K Madsen, ... Journal of medicinal chemistry 58 (18), 7370-7380, 2015 | 816 | 2015 |
| GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody C Pyke, RS Heller, RK Kirk, C Ørskov, S Reedtz-Runge, P Kaastrup, ... Endocrinology 155 (4), 1280-1290, 2014 | 769 | 2014 |
| Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation L Bjerre Knudsen, LW Madsen, S Andersen, K Almholt, AS de Boer, ... Endocrinology 151 (4), 1473-1486, 2010 | 654 | 2010 |
| The discovery and development of liraglutide and semaglutide LB Knudsen, J Lau Frontiers in endocrinology 10, 155, 2019 | 622 | 2019 |
| Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist ST Buckley, TA Bækdal, A Vegge, SJ Maarbjerg, C Pyke, J Ahnfelt-Rønne, ... Science translational medicine 10 (467), eaar7047, 2018 | 419 | 2018 |
| The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases β-cell mass in diabetic mice B Rolin, MO Larsen, CF Gotfredsen, CF Deacon, RD Carr, M Wilken, ... American Journal of Physiology-Endocrinology and Metabolism 283 (4), E745-E752, 2002 | 409 | 2002 |
| Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity CF Deacon, LB Knudsen, K Madsen, FC Wiberg, O Jacobsen, JJ Holst Diabetologia 41, 271-278, 1998 | 391 | 1998 |
| Structure-activity studies of glucagon-like peptide-1. K Adelhorst, BB Hedegaard, LB Knudsen, O Kirk Journal of Biological Chemistry 269 (9), 6275-6278, 1994 | 386 | 1994 |
| Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor CR Underwood, P Garibay, LB Knudsen, S Hastrup, GH Peters, ... Journal of Biological Chemistry 285 (1), 723-730, 2010 | 357 | 2010 |
| Semaglutide lowers body weight in rodents via distributed neural pathways S Gabery, CG Salinas, SJ Paulsen, J Ahnfelt-Rønne, T Alanentalo, ... JCI insight 5 (6), 2020 | 355 | 2020 |
| Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats PJ Larsen, C Fledelius, LB Knudsen, M Tang-Christensen Diabetes 50 (11), 2530-2539, 2001 | 326 | 2001 |
| The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways G Rakipovski, B Rolin, J Nøhr, I Klewe, KS Frederiksen, R Augustin, ... JACC: Basic to Translational Science 3 (6), 844-857, 2018 | 314 | 2018 |
| Expression of the GLP-1 receptor in mouse, rat, and human pancreas D Tornehave, P Kristensen, J Rømer, LB Knudsen, RS Heller Journal of Histochemistry & Cytochemistry 56 (9), 841-851, 2008 | 311 | 2008 |
| Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the … LB Knudsen, L Pridal European journal of pharmacology 318 (2-3), 429-435, 1996 | 309 | 1996 |
| Structure− activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness K Madsen, LB Knudsen, H Agersoe, PF Nielsen, H Thøgersen, M Wilken, ... Journal of medicinal chemistry 50 (24), 6126-6132, 2007 | 293 | 2007 |
| GLP‐1 derivative liraglutide in rats with β‐cell deficiencies: influence of metabolic state on β‐cell mass dynamics J Sturis, CF Gotfredsen, J Rømer, B Rolin, U Ribel, CL Brand, M Wilken, ... British journal of pharmacology 140 (1), 123-132, 2003 | 283 | 2003 |
| Glucagon-like peptide-1: the basis of a new class of treatment for type 2 diabetes LB Knudsen Journal of medicinal chemistry 47 (17), 4128-4134, 2004 | 260 | 2004 |
| Small-molecule agonists for the glucagon-like peptide 1 receptor LB Knudsen, D Kiel, M Teng, C Behrens, D Bhumralkar, JT Kodra, ... Proceedings of the National Academy of Sciences 104 (3), 937-942, 2007 | 253 | 2007 |
