| Integration of a CD19 CAR into the TCR alpha chain locus streamlines production of allogeneic gene-edited CAR T cells DT MacLeod, J Antony, AJ Martin, RJ Moser, A Hekele, KJ Wetzel, ... Molecular Therapy 25 (4), 949-961, 2017 | 312 | 2017 |
| A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered … BL Ellis, ML Hirsch, JC Barker, JP Connelly, RJ Steininger, MH Porteus Virology journal 10, 1-10, 2013 | 274 | 2013 |
| Efficient retrograde neuronal transduction utilizing self-complementary AAV1 ER Hollis Ii, K Kadoya, M Hirsch, RJ Samulski, MH Tuszynski Molecular Therapy 16 (2), 296-301, 2008 | 144 | 2008 |
| Role of ppGpp in rpoS Stationary-Phase Regulation in Escherichia coli M Hirsch, T Elliott Journal of bacteriology 184 (18), 5077-5087, 2002 | 138 | 2002 |
| Proteasome inhibitors enhance gene delivery by AAV virus vectors expressing large genomes in hemophilia mouse and dog models: a strategy for broad clinical application PE Monahan, CD Lothrop, J Sun, ML Hirsch, T Kafri, B Kantor, R Sarkar, ... Molecular therapy 18 (11), 1907-1916, 2010 | 135 | 2010 |
| Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs BL Ellis, ML Hirsch, SN Porter, RJ Samulski, MH Porteus Gene therapy 20 (1), 35-42, 2013 | 126 | 2013 |
| Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles C Li, N Diprimio, DE Bowles, ML Hirsch, PE Monahan, A Asokan, ... Journal of virology 86 (15), 7752-7759, 2012 | 119 | 2012 |
| Adeno‐associated virus as a mammalian DNA vector M Salganik, ML Hirsch, RJ Samulski Mobile DNA III, 827-849, 2015 | 112 | 2015 |
| Delivering transgenic DNA exceeding the carrying capacity of AAV vectors ML Hirsch, SJ Wolf, RJ Samulski Gene Therapy for Neurological Disorders: Methods and Protocols, 21-39, 2016 | 109 | 2016 |
| Little vector, big gene transduction: fragmented genome reassembly of adeno-associated virus ML Hirsch, M Agbandje-McKenna, RJ Samulski Molecular Therapy 18 (1), 6-8, 2010 | 103 | 2010 |
| Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo C Li, M Hirsch, A Asokan, B Zeithaml, H Ma, T Kafri, RJ Samulski Journal of virology 81 (14), 7540-7547, 2007 | 102 | 2007 |
| Double-stranded RNA innate immune response activation from long-term adeno-associated virus vector transduction W Shao, LF Earley, Z Chai, X Chen, J Sun, T He, M Deng, ML Hirsch, ... JCI insight 3 (12), 2018 | 101 | 2018 |
| Adeno-associated virus serotype-specific inverted terminal repeat sequence role in vector transgene expression LF Earley, LM Conatser, VM Lue, AL Dobbins, C Li, ML Hirsch, ... Human gene therapy 31 (3-4), 151-162, 2020 | 83 | 2020 |
| Cellular immune response to cryptic epitopes during therapeutic gene transfer C Li, K Goudy, M Hirsch, A Asokan, Y Fan, J Alexander, J Sun, ... Proceedings of the National Academy of Sciences 106 (26), 10770-10774, 2009 | 82 | 2009 |
| Direct interaction of human serum proteins with AAV virions to enhance AAV transduction: immediate impact on clinical applications M Wang, J Sun, A Crosby, K Woodard, ML Hirsch, RJ Samulski, C Li Gene therapy 24 (1), 49-59, 2017 | 77 | 2017 |
| Adeno-associated virus capsid antigen presentation is dependent on endosomal escape C Li, Y He, S Nicolson, M Hirsch, MS Weinberg, P Zhang, T Kafri, ... The Journal of clinical investigation 123 (3), 1390-1401, 2013 | 72 | 2013 |
| Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens SC Nicolson, C Li, ML Hirsch, V Setola, RJ Samulski Journal of virology 90 (16), 7019-7031, 2016 | 71 | 2016 |
| Adeno-associated virus vector mediated delivery of the HBV genome induces chronic hepatitis B virus infection and liver fibrosis in mice L Ye, H Yu, C Li, ML Hirsch, L Zhang, RJ Samulski, W Li, Z Liu PloS one 10 (6), e0130052, 2015 | 71 | 2015 |
| The prevalence of human parvovirus B19 DNA and antibodies in blood donors from four Chinese blood centers L Ke, M He, C Li, Y Liu, L Gao, F Yao, J Li, X Bi, Y Lv, J Wang, ML Hirsch, ... Transfusion 51 (9), 1909-1918, 2011 | 71 | 2011 |
| Oversized AAV transductifon is mediated via a DNA-PKcs-independent, Rad51C-dependent repair pathway ML Hirsch, C Li, I Bellon, C Yin, S Chavala, M Pryadkina, I Richard, ... Molecular Therapy 21 (12), 2205-2216, 2013 | 66 | 2013 |
