Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics M Ghoussaini, E Mountjoy, M Carmona, G Peat, EM Schmidt, A Hercules, ... Nucleic acids research 49 (D1), D1311-D1320, 2021 | 353 | 2021 |
The functional landscape of the human phosphoproteome D Ochoa, AF Jarnuczak, C Viéitez, M Gehre, M Soucheray, A Mateus, ... Nature biotechnology 38 (3), 365-373, 2020 | 332 | 2020 |
Open Targets Platform: supporting systematic drug–target identification and prioritisation D Ochoa, A Hercules, M Carmona, D Suveges, A Gonzalez-Uriarte, ... Nucleic acids research 49 (D1), D1302-D1310, 2021 | 323 | 2021 |
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci E Mountjoy, EM Schmidt, M Carmona, J Schwartzentruber, G Peat, ... Nature genetics 53 (11), 1527-1533, 2021 | 281 | 2021 |
The PROTACtable genome M Schneider, CJ Radoux, A Hercules, D Ochoa, I Dunham, LP Zalmas, ... Nature reviews Drug discovery 20 (10), 789-797, 2021 | 144 | 2021 |
The next-generation Open Targets Platform: reimagined, redesigned, rebuilt D Ochoa, A Hercules, M Carmona, D Suveges, J Baker, C Malangone, ... Nucleic acids research 51 (D1), D1353-D1359, 2023 | 133 | 2023 |
An atlas of human kinase regulation D Ochoa, M Jonikas, RT Lawrence, B El Debs, J Selkrig, A Typas, J Villén, ... Molecular systems biology 12 (12), 888, 2016 | 115 | 2016 |
Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs D Ochoa, M Karim, M Ghoussaini, DG Hulcoop, EM McDonagh, I Dunham Nat Rev Drug Discov 21 (8), 551, 2022 | 111 | 2022 |
Studying the co-evolution of protein families with the Mirrortree web server D Ochoa, F Pazos Bioinformatics 26 (10), 1370-1371, 2010 | 84 | 2010 |
Benchmarking substrate-based kinase activity inference using phosphoproteomic data C Hernandez-Armenta, D Ochoa, E Gonçalves, J Saez-Rodriguez, ... Bioinformatics 33 (12), 1845-1851, 2017 | 77 | 2017 |
Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set N Del-Toro, M Duesbury, M Koch, L Perfetto, A Shrivastava, D Ochoa, ... Nature communications 10 (1), 10, 2019 | 60 | 2019 |
Epigenomic co-localization and co-evolution reveal a key role for 5hmC as a communication hub in the chromatin network of ESCs D Juan, J Perner, EC de Santa Pau, S Marsili, D Ochoa, HR Chung, ... Cell reports 14 (5), 1246-1257, 2016 | 58 | 2016 |
Mondo: Unifying diseases for the world, by the world NA Vasilevsky, NA Matentzoglu, S Toro, JE Flack IV, H Hegde, DR Unni, ... MedRxiv, 2022.04. 13.22273750, 2022 | 46 | 2022 |
Conserved phosphorylation hotspots in eukaryotic protein domain families MJ Strumillo, M Oplová, C Viéitez, D Ochoa, M Shahraz, BP Busby, ... Nature communications 10 (1), 1977, 2019 | 46 | 2019 |
Systematic analysis of transcriptional and post-transcriptional regulation of metabolism in yeast E Gonçalves, Z Raguz Nakic, M Zampieri, O Wagih, D Ochoa, U Sauer, ... PLoS computational biology 13 (1), e1005297, 2017 | 45 | 2017 |
Network expansion of genetic associations defines a pleiotropy map of human cell biology I Barrio-Hernandez, J Schwartzentruber, A Shrivastava, N Del-Toro, ... Nature Genetics 55 (3), 389-398, 2023 | 40 | 2023 |
High-throughput functional characterization of protein phosphorylation sites in yeast C Viéitez, BP Busby, D Ochoa, A Mateus, D Memon, M Galardini, U Yildiz, ... Nature Biotechnology 40 (3), 382-390, 2022 | 39* | 2022 |
Practical aspects of protein co-evolution D Ochoa, F Pazos Frontiers in cell and developmental biology 2, 14, 2014 | 37 | 2014 |
Detection of significant protein coevolution D Ochoa, D Juan, A Valencia, F Pazos Bioinformatics 31 (13), 2166-2173, 2015 | 30 | 2015 |
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance M Anisul, J Shilts, J Schwartzentruber, J Hayhurst, A Buniello, ... elife 10, e69719, 2021 | 26 | 2021 |