Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania: characterization of gene deletion mutants SC Roberts, MJ Tancer, MR Polinsky, KM Gibson, O Heby, B Ullman Journal of Biological Chemistry 279 (22), 23668-23678, 2004 | 203 | 2004 |
Three distinct RNAs for the surface protease gp63 are differentially expressed during development of Leishmania donovani chagasi promastigotes to an infectious form. R Ramamoorthy, JE Donelson, KE Paetz, M Maybodi, SC Roberts, ... Journal of Biological Chemistry 267 (3), 1888-1895, 1992 | 147 | 1992 |
An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis U Gaur, SC Roberts, RP Dalvi, I Corraliza, B Ullman, ME Wilson The Journal of Immunology 179 (12), 8446-8453, 2007 | 144 | 2007 |
Ornithine decarboxylase gene deletion mutants of Leishmania donovani Y Jiang, SC Roberts, A Jardim, NS Carter, S Shih, M Ariyanayagam, ... Journal of Biological Chemistry 274 (6), 3781-3788, 1999 | 132 | 1999 |
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa O Heby, SC Roberts, B Ullman Biochemical Society Transactions 31 (2), 415-419, 2003 | 126 | 2003 |
Genetic analysis of spermidine synthase from Leishmania donovani SC Roberts, Y Jiang, A Jardim, NS Carter, O Heby, B Ullman Molecular and biochemical parasitology 115 (2), 217-226, 2001 | 116 | 2001 |
S-Adenosylmethionine Decarboxylase fromLeishmania donovani: MOLECULAR, GENETIC, AND BIOCHEMICAL CHARACTERIZATION OF NULL MUTANTS AND OVERPRODUCERS SC Roberts, J Scott, JE Gasteier, Y Jiang, B Brooks, A Jardim, NS Carter, ... Journal of Biological Chemistry 277 (8), 5902-5909, 2002 | 103 | 2002 |
Leishmania donovani Ornithine Decarboxylase Is Indispensable for Parasite Survival in the Mammalian Host JM Boitz, PA Yates, C Kline, U Gaur, ME Wilson, B Ullman, SC Roberts Infection and immunity 77 (2), 756-763, 2009 | 92 | 2009 |
Arginase is essential for survival of Leishmania donovani promastigotes but not intracellular amastigotes JM Boitz, CA Gilroy, TD Olenyik, D Paradis, J Perdeh, K Dearman, ... Infection and immunity 85 (1), 10.1128/iai. 00554-16, 2017 | 89 | 2017 |
Arginine homeostasis and transport in the human pathogen Leishmania donovani I Darlyuk, A Goldman, SC Roberts, B Ullman, D Rentsch, D Zilberstein Journal of biological chemistry 284 (30), 19800-19807, 2009 | 89 | 2009 |
Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections EL D’Antonio, B Ullman, SC Roberts, UG Dixit, ME Wilson, Y Hai, ... Archives of biochemistry and biophysics 535 (2), 163-176, 2013 | 88 | 2013 |
Learning bridge: curricular integration of didactic and experiential education R Karimi, CS Arendt, P Cawley, AV Buhler, F Elbarbry, SC Roberts American journal of pharmaceutical education 74 (3), 48, 2010 | 86 | 2010 |
Sequence diversity and organization of the msp gene family encoding gp63 of Leishmania chagasi SC Roberts, KG Swihart, MW Agey, R Ramamoorthy, ME Wilson, ... Molecular and biochemical parasitology 62 (2), 157-171, 1993 | 73 | 1993 |
Alpha-difluoromethylornithine, an irreversible inhibitor of polyamine biosynthesis, as a therapeutic strategy against hyperproliferative and infectious diseases N LoGiudice, L Le, I Abuan, Y Leizorek, SC Roberts Medical Sciences 6 (1), 12, 2018 | 69 | 2018 |
Spermidine synthase is required for virulence of Leishmania donovani C Gilroy, T Olenyik, SC Roberts, B Ullman Infection and immunity 79 (7), 2764-2769, 2011 | 61 | 2011 |
Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani B Chawla, A Jhingran, S Singh, N Tyagi, MH Park, N Srinivasan, ... Journal of biological chemistry 285 (1), 453-463, 2010 | 60 | 2010 |
Developmentally regulated expression of a novel 59-kDa product of the major surface protease (Msp or gp63) gene family of Leishmania chagasi SC Roberts, ME Wilson, JE Donelson Journal of Biological Chemistry 270 (15), 8884-8892, 1995 | 52 | 1995 |
Leishmania donovani Polyamine Biosynthetic Enzyme Overproducers as Tools To Investigate the Mode of Action of Cytotoxic Polyamine Analogs SC Roberts, Y Jiang, J Gasteier, B Frydman, LJ Marton, O Heby, B Ullman Antimicrobial agents and chemotherapy 51 (2), 438-445, 2007 | 47 | 2007 |
Inhibition profile of Leishmania mexicana arginase reveals differences with human arginase I E Riley, SC Roberts, B Ullman International journal for parasitology 41 (5), 545-552, 2011 | 44 | 2011 |
Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise NS Carter, BD Stamper, F Elbarbry, V Nguyen, S Lopez, Y Kawasaki, ... Microorganisms 9 (2), 267, 2021 | 31 | 2021 |