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Colin Flaveny PhD
Colin Flaveny PhD
Principal Scientist Pfizer
在 pfizer.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
AE Boitano, J Wang, R Romeo, LC Bouchez, AE Parker, SE Sutton, ...
Science 329 (5997), 1345-1348, 2010
12382010
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling
BC DiNatale, IA Murray, JC Schroeder, CA Flaveny, TS Lahoti, ...
Toxicological sciences 115 (1), 89-97, 2010
6462010
The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor
JC Schroeder, BC DiNatale, IA Murray, CA Flaveny, Q Liu, ...
Biochemistry 49 (2), 393-400, 2010
3162010
Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis
CA Flaveny, K Griffett, BEDM El-Gendy, M Kazantzis, M Sengupta, ...
Cancer cell 28 (1), 42-56, 2015
2002015
Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice
CA Flaveny, IA Murray, CR Chiaro, GH Perdew
Molecular pharmacology 75 (6), 1412-1420, 2009
1512009
Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis
FX Schaub, MS Reza, CA Flaveny, W Li, AM Musicant, S Hoxha, M Guo, ...
Cancer research 75 (23), 5023-5033, 2015
1232015
Differential gene regulation by the human and mouse aryl hydrocarbon receptor
CA Flaveny, IA Murray, GH Perdew
Toxicological Sciences 114 (2), 217-225, 2010
1202010
Ah receptor represses acute-phase response gene expression without binding to its cognate response element
RD Patel, IA Murray, CA Flaveny, A Kusnadi, GH Perdew
Laboratory investigation 89 (6), 695-707, 2009
1202009
Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity
IA Murray, JL Morales, CA Flaveny, BC DiNatale, C Chiaro, K Gowdahalli, ...
Molecular pharmacology 77 (2), 247-254, 2010
1182010
The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis
K Griffett, RD Welch, CA Flaveny, GR Kolar, BA Neuschwander-Tetri, ...
Molecular metabolism 4 (4), 353-357, 2015
872015
Pyrvinium attenuates Hedgehog signaling downstream of smoothened
B Li, DL Fei, CA Flaveny, N Dahmane, V Baubet, Z Wang, F Bai, XH Pei, ...
Cancer research 74 (17), 4811-4821, 2014
842014
Transgenic humanized AHR mouse reveals differences between human and mouse AHR ligand selectivity
CA Flaveny, GH Perdew
Molecular and cellular pharmacology 1 (3), 119, 2009
842009
Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties
IA Murray, G Krishnegowda, BC DiNatale, C Flaveny, C Chiaro, JM Lin, ...
Chemical research in toxicology 23 (5), 955-966, 2010
812010
Antagonism of aryl hydrocarbon receptor signaling by 6, 2′, 4′-trimethoxyflavone
IA Murray, CA Flaveny, BC DiNatale, CR Chairo, JC Schroeder, ...
Journal of Pharmacology and Experimental Therapeutics 332 (1), 135-144, 2010
792010
Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis
B Li, CA Flaveny, C Giambelli, DL Fei, L Han, BI Hang, F Bai, XH Pei, ...
PloS one 9 (7), e101969, 2014
682014
The mouse and human Ah receptor differ in recognition of LXXLL motifs
C Flaveny, RK Reen, A Kusnadi, GH Perdew
Archives of biochemistry and biophysics 471 (2), 215-223, 2008
602008
Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3′, 4′-dimethoxy-α-naphthoflavone
IA Murray, CA Flaveny, CR Chiaro, AK Sharma, RS Tanos, JC Schroeder, ...
Molecular Pharmacology 79 (3), 508-519, 2011
592011
Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract
S Sur, H Nakanishi, C Flaveny, JE Ippolito, J McHowat, DA Ford, RB Ray
Cell Communication and Signaling 17, 1-13, 2019
582019
Hedgehog signaling regulates bladder cancer growth and tumorigenicity
DL Fei, A Sanchez-Mejias, Z Wang, C Flaveny, J Long, S Singh, ...
Cancer research 72 (17), 4449-4458, 2012
572012
LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer
KJ Carpenter, AC Valfort, N Steinauer, A Chatterjee, S Abuirqeba, ...
Scientific reports 9 (1), 19530, 2019
492019
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