SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner P Rada, AI Rojo, S Chowdhry, M McMahon, JD Hayes, A Cuadrado Molecular and cellular biology, 2011 | 822 | 2011 |
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis P Rada, AI Rojo, N Evrard-Todeschi, NG Innamorato, A Cotte, T Jaworski, ... Molecular and cellular biology 32 (17), 3486-3499, 2012 | 366 | 2012 |
Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? P Rada, Á González-Rodríguez, C García-Monzón, ÁM Valverde Cell death & disease 11 (9), 802, 2020 | 335 | 2020 |
Redox control of microglial function: molecular mechanisms and functional significance AI Rojo, G McBean, M Cindric, J Egea, MG López, P Rada, N Zarkovic, ... Antioxidants & redox signaling 21 (12), 1766-1801, 2014 | 316 | 2014 |
Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: role of glycogen synthase kinase-3 AI Rojo, ON Medina-Campos, P Rada, A Zúñiga-Toalá, A López-Gazcón, ... Free Radical Biology and Medicine 52 (2), 473-487, 2012 | 215 | 2012 |
NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology AI Rojo, M Pajares, P Rada, A Nuñez, AJ Nevado-Holgado, R Killik, ... Redox biology 13, 444-451, 2017 | 184 | 2017 |
Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal celldeath AI Rojo, P Rada, J Egea, AO Rosa, MG López, A Cuadrado Molecular and Cellular Neuroscience 39 (1), 125-132, 2008 | 138 | 2008 |
The PTEN/NRF2 axis promotes human carcinogenesis AI Rojo, P Rada, M Mendiola, A Ortega-Molina, K Wojdyla, ... Antioxidants & redox signaling 21 (18), 2498-2514, 2014 | 122 | 2014 |
SIRT1 controls acetaminophen hepatotoxicity by modulating inflammation and oxidative stress P Rada, V Pardo, MA Mobasher, I García-Martínez, L Ruiz, ... Antioxidants & redox signaling 28 (13), 1187-1208, 2018 | 113 | 2018 |
Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease M Zarei, E Barroso, X Palomer, J Dai, P Rada, T Quesada-López, ... Molecular metabolism 8, 117-131, 2018 | 101 | 2018 |
Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity MA Mobasher, Á González-Rodríguez, B Santamaría, S Ramos, ... Cell death & disease 4 (5), e626-e626, 2013 | 93 | 2013 |
Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1‐independent manner Á González‐Rodríguez, B Santamaría, JA Mas‐Gutierrez, P Rada, ... Molecular nutrition & food research 59 (8), 1431-1442, 2015 | 78 | 2015 |
Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress ÁJ García-Yagüe, P Rada, AI Rojo, I Lastres-Becker, A Cuadrado Journal of Biological Chemistry 288 (8), 5506-5517, 2013 | 77 | 2013 |
WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes P Rada, AI Rojo, A Offergeld, GJ Feng, JP Velasco-Martín, ... Antioxidants & Redox Signaling 22 (7), 555-571, 2015 | 64 | 2015 |
Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line AE Freitas, J Egea, I Buendía, E Navarro, P Rada, A Cuadrado, ... Molecular neurobiology 51, 1504-1519, 2015 | 63 | 2015 |
Melatonin–sulforaphane hybrid ITH 12674 induces neuroprotection in oxidative stress conditions by a ‘drug–prodrug’mechanism of action J Egea, I Buendia, E Parada, E Navarro, P Rada, A Cuadrado, MG López, ... British journal of pharmacology 172 (7), 1807-1821, 2015 | 47 | 2015 |
Insights into extracellular vesicles as biomarker of NAFLD pathogenesis I Garcia-Martinez, R Alen, P Rada, AM Valverde Frontiers in Medicine 7, 395, 2020 | 26 | 2020 |
Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases I García-Ruiz, NB Ruiz, P Rada, V Pardo, L Ruiz, A Blas-García, ... Redox biology 26, 101263, 2019 | 26 | 2019 |
Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis Á González-Rodríguez, MP Valdecantos, P Rada, A Addante, I Barahona, ... Molecular metabolism 7, 132-146, 2018 | 26 | 2018 |
Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans M Cruces-Sande, R Vila-Bedmar, AC Arcones, A Gonzalez-Rodriguez, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (12 …, 2018 | 20 | 2018 |