Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma RP Koche*, E Rodriguez-Fos*, K Helmsauer*, M Burkert, IC MacArthur, ... Nature genetics 52 (1), 29-34, 2020 | 293 | 2020 |
EcDNA hubs drive cooperative intermolecular oncogene expression KL Hung*, KE Yost*, L Xie*, Q Shi, K Helmsauer, J Luebeck, R Schöpflin, ... Nature 600, 731-736, 2021 | 208 | 2021 |
Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma K Helmsauer*, ME Valieva*, S Ali*, RC González, R Schöpflin, ... Nature communications 11 (1), 1-12, 2020 | 164 | 2020 |
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells R Chamorro González, T Conrad, MC Stöber, R Xu, M Giurgiu, ... Nature Genetics 55 (5), 880-890, 2023 | 41 | 2023 |
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma H Dorado García, F Pusch, Y Bei, J von Stebut, G Ibáñez, K Guillan, ... Nature Communications 13 (1), 4297, 2022 | 17 | 2022 |
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN S Fuchs, C Danßmann, F Klironomos, A Winkler, J Fallmann, ... Nature Communications 14 (1), 3936, 2023 | 8 | 2023 |
Enhancer hijacking determines intra-and extrachromosomal circular MYCN amplicon architecture in neuroblastoma K Helmsauer, M Valieva, S Ali, R Chamorro González, R Schöpflin, ... bioRxiv, 2019 | 5 | 2019 |
Decoil: Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data M Giurgiu, N Wittstruck, E Rodriguez-Fos, RC Gonzalez, L Brückner, ... International Conference on Research in Computational Molecular Biology, 406-411, 2024 | 4 | 2024 |
Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil M Giurgiu, N Wittstruck, E Rodriguez-Fos, RC González, L Brückner, ... Genome research 34 (9), 1355-1364, 2024 | 3 | 2024 |
Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy HD García, Y Bei, J von Stebut, G Ibáñez, K Imami, D Gürgen, J Rolff, ... bioRxiv, 2020.12. 04.411413, 2020 | 1 | 2020 |
Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil K Helmsauer, A Hartebrodt, P Euskirchen, RP Koche | | 2024 |
Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy L Grunewald, L Andersch, K Helmsauer, S Schwiebert, A Klaus, ... bioRxiv, 2024.01. 27.576592, 2024 | | 2024 |
MYCN amplification in neuroblastoma: sequence, chromatin landscape, and genome remodeling K Helmsauer | | 2023 |
Dissecting intercellular extrachromosomal circular DNA heterogeneity in single cancer cells with scEC&T-seq RC Gonzalez, T Conrad, R Xu, M Giurgiu, M Cwikla, K Kasack, ... Cancer Research 82 (12_Supplement), 1693-1693, 2022 | | 2022 |
Enhancer hijacking on the MYCN amplicon in neuroblastoma K Helmsauer, M Valieva, S Ali, RC Gonzalez, R Schöpflin, JH Schulte, ... Klinische Pädiatrie 232 (03), 2020 | | 2020 |