Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown L Tweedy, PA Thomason, PI Paschke, K Martin, LM Machesky, M Zagnoni, ... Science 369 (6507), eaay9792, 2020 | 141 | 2020 |
Self-generated chemoattractant gradients: attractant depletion extends the range and robustness of chemotaxis L Tweedy, DA Knecht, GM Mackay, RH Insall PLoS biology 14 (3), e1002404, 2016 | 140 | 2016 |
Distinct cell shapes determine accurate chemotaxis L Tweedy, B Meier, J Stephan, D Heinrich, RG Endres Scientific reports 3 (1), 2606, 2013 | 82 | 2013 |
Fam49/CYRI interacts with Rac1 and locally suppresses protrusions L Fort, JM Batista, PA Thomason, HJ Spence, JA Whitelaw, L Tweedy, ... Nature cell biology 20 (10), 1159-1171, 2018 | 72 | 2018 |
Self-generated chemotactic gradients—cells steering themselves L Tweedy, O Susanto, RH Insall Current opinion in cell biology 42, 46-51, 2016 | 62 | 2016 |
LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells O Susanto, YWH Koh, N Morrice, S Tumanov, PA Thomason, M Nielson, ... Journal of cell science 130 (20), 3455-3466, 2017 | 52 | 2017 |
Self-generated gradients yield exceptionally robust steering cues L Tweedy, RH Insall Frontiers in Cell and Developmental Biology 8, 133, 2020 | 47 | 2020 |
Memory improves precision of cell sensing in fluctuating environments G Aquino, L Tweedy, D Heinrich, RG Endres Scientific reports 4 (1), 5688, 2014 | 38 | 2014 |
The atypical MAP kinase ErkB transmits distinct chemotactic signals through a core signaling module JME Nichols, P Paschke, S Peak-Chew, TD Williams, L Tweedy, M Skehel, ... Developmental Cell 48 (4), 491-505. e9, 2019 | 30 | 2019 |
Steering yourself by the bootstraps: how cells create their own gradients for chemotaxis RH Insall, P Paschke, L Tweedy Trends in Cell Biology 32 (7), 585-596, 2022 | 16 | 2022 |
Screening by changes in stereotypical behavior during cell motility L Tweedy, P Witzel, D Heinrich, RH Insall, RG Endres Scientific reports 9 (1), 8784, 2019 | 13 | 2019 |
Simulation of melanoblast displacements reveals new features of developmental migration P Laurent-Gengoux, V Petit, Z Aktary, S Gallagher, L Tweedy, L Machesky, ... Development 145 (12), dev160200, 2018 | 9 | 2018 |
Competition between chemoattractants causes unexpected complexity and can explain negative chemotaxis A Dowdell, PI Paschke, PA Thomason, L Tweedy, RH Insall Current Biology 33 (9), 1704-1715. e3, 2023 | 7 | 2023 |
The Scar/WAVE complex drives normal actin protrusions without the Arp2/3 complex, but proline-rich domains are required S Buracco, S Singh, S Claydon, P Paschke, L Tweedy, J Whitelaw, ... bioRxiv, 2022.05. 14.491902, 2022 | 4 | 2022 |
AKT and SGK kinases regulate cell migration by altering Scar/WAVE complex activation and Arp2/3 complex recruitment SP Singh, P Paschke, L Tweedy, RH Insall Frontiers in Molecular Biosciences 9, 965921, 2022 | 2 | 2022 |
Seeing around corners: Cells create chemotactic gradients to solve mazes and respond to distant cues in complex environments L Tweedy, PA Thomason, K Martin, M Zagnoni, LM Machesky, RH Insall bioRxiv, 836056, 2019 | 2 | 2019 |
The Chemoattractant Glorin Is Inactivated by Ester Cleavage during Early Multicellular Development of Polysphondylium pallidum D Heinrich, R Barnett, L Tweedy, R Insall, P Stallforth, T Winckler ACS Chemical Biology 13 (6), 1506-1513, 2018 | 1 | 2018 |
Meinhart Simulations on an Evolving Line L Tweedy Technical Report, Cside 2018 Supplementary Notes, 2018 | 1 | 2018 |
A Reliable System for Quantitative G-Protein Activation Imaging in Cancer Cells E Mandrou, PA Thomason, PI Paschke, NR Paul, L Tweedy, RH Insall Cells 13 (13), 1114, 2024 | | 2024 |
CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge JA Whitelaw, S Lilla, S Nikolaou, L Tweedy, L Fort, NR Paul, S Zanivan, ... bioRxiv, 2024.03. 26.586838, 2024 | | 2024 |