| Intratumor heterogeneity and branched evolution revealed by multiregion sequencing M Gerlinger, AJ Rowan, S Horswell, J Larkin, D Endesfelder, E Gronroos, ... N Engl j Med 366, 883-892, 2012 | 7994 | 2012 |
| A structural superfamily of growth factors containing a cystine knot motif NQ McDonald, WA Hendrickson Cell 73 (3), 421-424, 1993 | 805 | 1993 |
| New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor NQ McDonald, R Lapatto, JM Rust, J Gunning, A Wlodawer, TL Blundell Nature 354 (6352), 411-414, 1991 | 678 | 1991 |
| The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1 H Plun-Favreau, K Klupsch, N Moisoi, S Gandhi, S Kjaer, D Frith, ... Nature cell biology 9 (11), 1243-1252, 2007 | 558 | 2007 |
| Disruption of methylarginine metabolism impairs vascular homeostasis J Leiper, M Nandi, B Torondel, J Murray-Rust, M Malaki, B O'Hara, ... Nature medicine 13 (2), 198-203, 2007 | 466 | 2007 |
| Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM A Ciccia, C Ling, R Coulthard, Z Yan, Y Xue, AR Meetei, EH Laghmani, ... Molecular cell 25 (3), 331-343, 2007 | 396 | 2007 |
| S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine … J Leiper, J Murray-Rust, N McDonald, P Vallance Proceedings of the National Academy of Sciences 99 (21), 13527-13532, 2002 | 383 | 2002 |
| Structural and functional relationships of the XPF/MUS81 family of proteins A Ciccia, N McDonald, SC West Annu. Rev. Biochem. 77, 259-287, 2008 | 329 | 2008 |
| Structure and chemical inhibition of the RET tyrosine kinase domain PP Knowles, J Murray-Rust, S Kjær, RP Scott, S Hanrahan, M Santoro, ... Journal of biological chemistry 281 (44), 33577-33587, 2006 | 317 | 2006 |
| Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase J Murray-Rust, J Leiper, M McAlister, J Phelan, S Tilley, JS Maria, ... nature structural biology 8 (8), 679-683, 2001 | 309 | 2001 |
| Epidermal growth factor binding induces a conformational change in the external domain of its receptor. C Greenfield, I Hiles, MD Waterfield, M Federwisch, A Wollmer, ... The EMBO journal 8 (13), 4115-4123, 1989 | 235 | 1989 |
| The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition G Nicastro, RP Menon, L Masino, PP Knowles, NQ McDonald, A Pastore Proceedings of the National Academy of Sciences 102 (30), 10493-10498, 2005 | 228 | 2005 |
| Topological similarities in TGF-β2, PDGF-BB and NGF define a superfamily of polypeptide growth factors J Murray-Rust, NQ McDonald, TL Blundell, M Hosang, C Oefner, ... Structure 1 (2), 153-159, 1993 | 213 | 1993 |
| A heterozygous effect for PINK1 mutations in Parkinson's disease? PM Abou‐Sleiman, MMK Muqit, NQ McDonald, YX Yang, S Gandhi, ... Annals of neurology 60 (4), 414-419, 2006 | 203 | 2006 |
| Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. NQ McDonald, N Panayotatos, WA Hendrickson The EMBO journal 14 (12), 2689-2699, 1995 | 194 | 1995 |
| Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation AE Stewart, S Dowd, SM Keyse, NQ McDonald Nature structural biology 6 (2), 174-181, 1999 | 189 | 1999 |
| The dual mechanism of separase regulation by securin NCD Hornig, PP Knowles, NQ McDonald, F Uhlmann Current biology 12 (12), 973-982, 2002 | 183 | 2002 |
| Crystal structure of the C2 domain from protein kinase C-δ H Pappa, J Murray-Rust, LV Dekker, PJ Parker, NQ McDonald Structure 6 (7), 885-894, 1998 | 162 | 1998 |
| A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN) E Rosivatz, JG Matthews, NQ McDonald, X Mulet, KK Ho, N Lossi, ... ACS chemical biology 1 (12), 780-790, 2006 | 157 | 2006 |
| Functional analysis of mutant neurotrophins deficient in low‐affinity binding reveals a role for p75LNGFR in NT‐4 signalling. M Ryden, J Murray‐Rust, D Glass, LL Ilag, M Trupp, GD Yancopoulos, ... The EMBO Journal 14 (9), 1979-1990, 1995 | 155 | 1995 |
