| MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis AL Samson, Y Zhang, ND Geoghegan, XJ Gavin, KA Davies, ... Nature communications 11 (1), 3151, 2020 | 243 | 2020 |
| The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis KA Davies, MC Tanzer, MDW Griffin, YF Mok, SN Young, R Qin, EJ Petrie, ... Cell Death & Differentiation 25 (9), 1567-1580, 2018 | 81 | 2018 |
| Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies EJ Petrie, RW Birkinshaw, A Koide, E Denbaum, JM Hildebrand, ... Proceedings of the National Academy of Sciences 117 (15), 8468-8475, 2020 | 66 | 2020 |
| Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis Y Meng, KA Davies, C Fitzgibbon, SN Young, SE Garnish, CR Horne, ... Nature Communications 12 (1), 6783, 2021 | 57 | 2021 |
| Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues KA Davies, C Fitzgibbon, SN Young, SE Garnish, W Yeung, D Coursier, ... Nature Communications 11 (1), 3060, 2020 | 51 | 2020 |
| Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL A Sethi, CR Horne, C Fitzgibbon, K Wilde, KA Davies, SE Garnish, ... Cell Death & Differentiation 29 (9), 1804-1815, 2022 | 25 | 2022 |
| From (Tool) Bench to Bedside: The Potential of Necroptosis Inhibitors CR Gardner, KA Davies, Y Zhang, M Brzozowski, PE Czabotar, ... Journal of Medicinal Chemistry 66 (4), 2361-2385, 2023 | 15 | 2023 |
| Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization Y Meng, SE Garnish, KA Davies, KA Black, AP Leis, CR Horne, ... Nature Communications 14 (1), 6804, 2023 | 4 | 2023 |
| The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase CL Pierotti, AV Jacobsen, C Grohmann, RK Dempsey, N Etemadi, ... Biochemical Journal 480 (9), 665-684, 2023 | 4 | 2023 |
| Death at a funeral: Activation of the dead enzyme, MLKL, to kill cells by necroptosis KA Davies, PE Czabotar, JM Murphy Current Opinion in Structural Biology 88, 102891, 2024 | | 2024 |
| Sulphonamide compounds JMD Garnier, M Brzozowski, JT Feutrill, GL Lessene, C Gardner, ... US Patent App. 18/011,410, 2023 | | 2023 |
