关注
Stephen Bearne
Stephen Bearne
Professor, Departments of Biochemistry & Molecular Biology and Chemistry, Dalhousie University
在 dal.ca 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Mandelate racemase in pieces: effective concentrations of enzyme functional groups in the transition state
SL Bearne, R Wolfenden
Biochemistry 36 (7), 1646-1656, 1997
811997
Inhibition of Escherichia coli CTP synthase by glutamate γ-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis
SL Bearne, O Hekmat, JE MacDONNELL
Biochemical Journal 356 (1), 223-232, 2001
702001
Proteomic investigation of amino acid catabolism in the indigenous gut anaerobe Fusobacterium varium
J Potrykus, RL White, SL Bearne
Proteomics 8 (13), 2691-2703, 2008
682008
Inhibition of Escherichia coliGlucosamine-6-phosphate Synthase by Reactive Intermediate Analogues: THE ROLE OF THE 2-AMINO FUNCTION IN CATALYSIS
SL Bearne, C Blouin
Journal of Biological Chemistry 275 (1), 135-140, 2000
682000
Glutamate. gamma.-Semialdehyde as a Natural Transition State Analog Inhibitor of Escherichia coli Glucosamine-6-phosphate Synthase
SL Bearne, R Wolfenden
Biochemistry 34 (36), 11515-11520, 1995
621995
Kinetics and thermodynamics of mandelate racemase catalysis
M St. Maurice, SL Bearne
Biochemistry 41 (12), 4048-4058, 2002
552002
Oxidative stress response in the opportunistic oral pathogen Fusobacterium nucleatum
CH Steeves, J Potrykus, DA Barnett, SL Bearne
Proteomics 11 (10), 2027-2037, 2011
492011
Hydrophobic nature of the active site of mandelate racemase
M St. Maurice, SL Bearne
Biochemistry 43 (9), 2524-2532, 2004
492004
Dicarboxylic acid bis (methyl phosphates): anionic biomimetic crosslinking reagents
R Kluger, AS Grant, SL Bearne, MR Trachsel
The Journal of Organic Chemistry 55 (9), 2864-2868, 1990
491990
Reaction intermediate analogues for mandelate racemase: interaction between Asn 197 and the α-hydroxyl of the substrate promotes catalysis
M St. Maurice, SL Bearne
Biochemistry 39 (44), 13324-13335, 2000
482000
Active site-directed inactivation of Escherichia coli glucosamine-6-phosphate synthase: determination of the fructose 6-phosphate binding constant using a carbohydrate-based …
SL Bearne
Journal of Biological Chemistry 271 (6), 3052-3057, 1996
451996
Purification of recombinant mandelate racemase: improved catalytic activity
A Narmandakh, SL Bearne
Protein expression and purification 69 (1), 39-46, 2010
412010
Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase
A Iyengar, SL Bearne
Biochemical Journal 369 (3), 497-507, 2003
412003
Proteomic investigation of glucose metabolism in the butyrate‐producing gut anaerobe Fusobacterium varium
J Potrykus, B Mahaney, RL White, SL Bearne
Proteomics 7 (11), 1839-1853, 2007
392007
Inhibition of E. coli CTP synthase by the “positive” allosteric effector GTP
JE MacDonnell, FA Lunn, SL Bearne
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1699 (1-2), 213-220, 2004
382004
Enzymic hydration of an olefin: the burden borne by fumarase
SL Bearne, R Wolfenden
Journal of the American Chemical Society 117 (37), 9588-9589, 1995
381995
Structural requirements for the activation of Escherichia coli CTP synthase by the allosteric effector GTP are stringent, but requirements for inhibition are lax
FA Lunn, JE MacDonnell, SL Bearne
Journal of Biological Chemistry 283 (4), 2010-2020, 2008
362008
Perturbing the hydrophobic pocket of mandelate racemase to probe phenyl motion during catalysis
F Siddiqi, JR Bourque, H Jiang, M Gardner, M St. Maurice, C Blouin, ...
Biochemistry 44 (25), 9013-9021, 2005
362005
Exploring the potent inhibition of CTP synthase by gemcitabine‐5′‐triphosphate
GD McCluskey, S Mohamady, SD Taylor, SL Bearne
Chembiochem 17 (23), 2240-2249, 2016
342016
Structure of mandelate racemase with bound intermediate analogues benzohydroxamate and cupferron
AD Lietzan, M Nagar, EA Pellmann, JR Bourque, SL Bearne, ...
Biochemistry 51 (6), 1160-1170, 2012
342012
系统目前无法执行此操作,请稍后再试。
文章 1–20