| Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii WF Penwell, AB Shapiro, RA Giacobbe, RF Gu, N Gao, J Thresher, ... Antimicrobial agents and chemotherapy 59 (3), 1680-1689, 2015 | 221 | 2015 |
| Meropenem-vaborbactam tested against contemporary Gram-negative isolates collected worldwide during 2014, including carbapenem-resistant, KPC-producing, multidrug-resistant … M Castanheira, MD Huband, RE Mendes, RK Flamm Antimicrobial agents and chemotherapy 61 (9), 10.1128/aac. 00567-17, 2017 | 182 | 2017 |
| A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore JR Miller, S Dunham, I Mochalkin, C Banotai, M Bowman, S Buist, ... Proceedings of the National Academy of Sciences 106 (6), 1737-1742, 2009 | 174 | 2009 |
| Multicity Outbreak of Linezolid-Resistant Staphylococcus epidermidis Associated with Clonal Spread of a cfr-Containing Strain H Bonilla, MD Huband, J Seidel, H Schmidt, MK Lescoe, SP McCurdy, ... Clinical infectious diseases 51 (7), 796-800, 2010 | 129 | 2010 |
| Pseudomonas aeruginosa antimicrobial susceptibility results from four years (2012 to 2015) of the international network for optimal resistance monitoring program in the United … HS Sader, MD Huband, M Castanheira, RK Flamm Antimicrobial agents and chemotherapy 61 (3), 10.1128/aac. 02252-16, 2017 | 127 | 2017 |
| Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches I Mochalkin, JR Miller, L Narasimhan, V Thanabal, P Erdman, PB Cox, ... ACS chemical biology 4 (6), 473-483, 2009 | 115 | 2009 |
| Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections JI Montgomery, MF Brown, U Reilly, LM Price, JA Abramite, J Arcari, ... Journal of medicinal chemistry 55 (4), 1662-1670, 2012 | 113 | 2012 |
| The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents ST Murphy, HL Case, E Ellsworth, S Hagen, M Huband, T Joannides, ... Bioorganic & medicinal chemistry letters 17 (8), 2150-2155, 2007 | 112 | 2007 |
| Geographic and Temporal Patterns of Antimicrobial Resistance in Pseudomonas aeruginosa Over 20 Years From the SENTRY Antimicrobial Surveillance Program … D Shortridge, AC Gales, JM Streit, MD Huband, A Tsakris, RN Jones Open forum infectious diseases 6 (Supplement_1), S63-S68, 2019 | 111 | 2019 |
| Potent inhibitors of LpxC for the treatment of Gram-negative infections MF Brown, U Reilly, JA Abramite, JT Arcari, R Oliver, RA Barham, Y Che, ... Journal of medicinal chemistry 55 (2), 914-923, 2012 | 111 | 2012 |
| Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases GS Basarab, GH Kern, J McNulty, JP Mueller, K Lawrence, ... Scientific reports 5 (1), 11827, 2015 | 105 | 2015 |
| Surveillance of omadacycline activity tested against clinical isolates from the United States and Europe: report from the SENTRY Antimicrobial Surveillance Program, 2016 to 2018 MA Pfaller, MD Huband, D Shortridge, RK Flamm Antimicrobial agents and chemotherapy 64 (5), 10.1128/aac. 02488-19, 2020 | 102 | 2020 |
| In vitro activity of meropenem/vaborbactam and characterisation of carbapenem resistance mechanisms among carbapenem-resistant Enterobacteriaceae from the 2015 meropenem … MA Pfaller, MD Huband, RE Mendes, RK Flamm, M Castanheira International journal of antimicrobial agents 52 (2), 144-150, 2018 | 100 | 2018 |
| Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae RA Alm, SD Lahiri, A Kutschke, LG Otterson, RE McLaughlin, ... Antimicrobial agents and chemotherapy 59 (3), 1478-1486, 2015 | 97 | 2015 |
| In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram … MD Huband, MA Cohen, M Zurack, DL Hanna, LA Skerlos, MC Sulavik, ... Antimicrobial agents and chemotherapy 51 (4), 1191-1201, 2007 | 97 | 2007 |
| The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy-and 5-amino-8-alkoxyquinolone antibacterial agents JP Sanchez, RD Gogliotti, JM Domagala, SJ Gracheck, MD Huband, ... Journal of medicinal chemistry 38 (22), 4478-4487, 1995 | 96 | 1995 |
| In Vitro Antibacterial Activity of AZD0914, a New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious … MD Huband, PA Bradford, LG Otterson, GS Basarab, AC Kutschke, ... Antimicrobial agents and chemotherapy 59 (1), 467-474, 2015 | 85 | 2015 |
| WCK 5222 (cefepime-zidebactam) antimicrobial activity against clinical isolates of Gram-negative bacteria collected worldwide in 2015 HS Sader, M Castanheira, M Huband, RN Jones, RK Flamm Antimicrobial Agents and Chemotherapy 61 (5), 10.1128/aac. 00072-17, 2017 | 82 | 2017 |
| High In Vitro Activity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a … S Jacobsson, D Golparian, RA Alm, M Huband, J Mueller, JS Jensen, ... Antimicrobial agents and chemotherapy 58 (9), 5585-5588, 2014 | 82 | 2014 |
| 5-(2-Pyrimidinyl)-imidazo [1, 2-a] pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV JT Starr, RJ Sciotti, DL Hanna, MD Huband, LM Mullins, H Cai, JW Gage, ... Bioorganic & medicinal chemistry letters 19 (18), 5302-5306, 2009 | 79 | 2009 |
