The bacterial ribosome as a target for antibiotics J Poehlsgaard, S Douthwaite Nature Reviews Microbiology 3 (11), 870-881, 2005 | 746 | 2005 |
Macrolide resistance conferred by base substitutions in 23S rRNA B Vester, S Douthwaite Antimicrobial agents and chemotherapy 45 (1), 1-12, 2001 | 738 | 2001 |
The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA LH Hansen, P Mauvais, S Douthwaite Molecular microbiology 31 (2), 623-631, 1999 | 392 | 1999 |
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs SK Johansen, CE Maus, BB Plikaytis, S Douthwaite Molecular cell 23 (2), 173-182, 2006 | 343 | 2006 |
Basis for prokaryotic specificity of action of aminoglycoside antibiotics MI Recht, S Douthwaite, JD Puglisi The EMBO journal, 1999 | 343 | 1999 |
The ketolides: a critical review GG Zhanel, M Walters, A Noreddin, LM Vercaigne, A Wierzbowski, ... Drugs 62, 1771-1804, 2002 | 250 | 2002 |
Macrolide–ketolide inhibition of MLS‐resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA S Douthwaite, LH Hansen, P Mauvais Molecular microbiology 36 (1), 183-193, 2000 | 243 | 2000 |
Oxazolidinone Resistance Mutations in 23S rRNA of Escherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action L Xiong, P Kloss, S Douthwaite, NM Andersen, S Swaney, ... Journal of bacteriology 182 (19), 5325-5331, 2000 | 230 | 2000 |
A “bulged” double helix in a RNA-protein contact site DA Peattie, S Douthwaite, RA Garrett, HF and Noller Proc. Natl. Acad. Sci. USA 78, 7331-7335, 1981 | 191 | 1981 |
LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage B Vester, LB Lundberg, MD Sørensen, BR Babu, S Douthwaite, J Wengel Journal of the American Chemical Society 124 (46), 13682-13683, 2002 | 171 | 2002 |
Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site S Douthwaite, WS Champney Journal of Antimicrobial Chemotherapy 48 (suppl_2), 1-8, 2001 | 166 | 2001 |
Characterization of the binding sites of protein L11 and the L10.(L12) 4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli J Egebjerg, SR Douthwaite, A Liljas, RA Garrett Journal of molecular biology 213 (2), 275-288, 1990 | 161 | 1990 |
The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A G Rosendahl, S Douthwaite Nucleic acids research 22 (3), 357-363, 1994 | 155 | 1994 |
Mapping posttranscriptional modifications in 5S ribosomal RNA by MALDI mass spectrometry. F Kirpekar, S Douthwaite, P Roepstorff RNA 6 (2), 296-306, 2000 | 150 | 2000 |
Macrolide Resistance by Ribosomal Mutation in Clinical Isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 Study DJ Farrell, S Douthwaite, I Morrissey, S Bakker, J Poehlsgaard, ... Antimicrobial agents and chemotherapy 47 (6), 1777-1783, 2003 | 147 | 2003 |
Interconversion of active and inactive 30 S ribosomal subunits is accompanied by a conformational change in the decoding region of 16 S rRNA D Moazed, BJ Van Stolk, S Douthwaite, HF Noller Journal of molecular biology 191 (3), 483-493, 1986 | 147 | 1986 |
Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction MI Recht, S Douthwaite, KD Dahlquist, JD Puglisi Journal of molecular biology 286 (1), 33-43, 1999 | 145 | 1999 |
YebU is a m5C methyltransferase specific for 16S rRNA nucleotide 1407 NM Andersen, S Douthwaite Journal of molecular biology 359 (3), 777-786, 2006 | 139 | 2006 |
Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK L Hidalgo, KL Hopkins, B Gutierrez, CM Ovejero, S Shukla, S Douthwaite, ... Journal of Antimicrobial Chemotherapy 68, 1543-1550, 2013 | 138 | 2013 |
Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA M Liu, S Douthwaite Antimicrobial Agents and Chemotherapy 46 (6), 1629-1633, 2002 | 131 | 2002 |