| A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells ACS Chem. Biol., 2021 | 96 | 2021 |
| Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis Y Park, A Pacitto, T Bayliss, LAT Cleghorn, Z Wang, T Hartman, K Arora, ... ACS infectious diseases 3 (1), 18-33, 2017 | 85 | 2017 |
| Purine salvage pathway in Mycobacterium tuberculosis R G Ducati, A Breda, L A Basso, D S Santos Current medicinal chemistry 18 (9), 1258-1275, 2011 | 75 | 2011 |
| Protein structure, modelling and applications A Breda, NF Valadares, ON de Souza, RC Garratt Bioinformatics in tropical disease research: a practical and case-study …, 2007 | 58 | 2007 |
| Virtual screening of drugs: score functions, docking, and drug design A Breda, LA Basso, DS Santos, JR De Azevedo, F Walter Current Computer-Aided Drug Design 4 (4), 265-272, 2008 | 53 | 2008 |
| Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum FM Jordão, HB Gabriel, JMP Alves, CB Angeli, TD Bifano, A Breda, ... Malaria Journal 12, 1-15, 2013 | 46 | 2013 |
| Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme–ligand binary complex formation LKB Martinelli, RG Ducati, LA Rosado, A Breda, BP Selbach, DS Santos, ... Molecular bioSystems 7 (4), 1289-1305, 2011 | 27 | 2011 |
| Pyrimidin-2 (1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase A Breda, P Machado, LA Rosado, AA Souto, DS Santos, LA Basso European journal of medicinal chemistry 54, 113-122, 2012 | 23 | 2012 |
| Structure, activity, and inhibition of the carboxyltransferase β-subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis MCM Reddy, A Breda, JB Bruning, M Sherekar, S Valluru, C Thurman, ... Antimicrobial agents and chemotherapy 58 (10), 6122-6132, 2014 | 21 | 2014 |
| Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase A Breda, LA Rosado, DM Lorenzini, LA Basso, DS Santos Molecular BioSystems 8 (2), 572-586, 2012 | 20 | 2012 |
| Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1. 1.23) JES Nunes, RG Ducati, A Breda, LA Rosado, BM De Souza, MS Palma, ... Archives of biochemistry and biophysics 512 (2), 143-153, 2011 | 20 | 2011 |
| A hybrid method for the protein structure prediction problem M Dorn, A Breda, O Norberto de Souza Advances in Bioinformatics and Computational Biology: Third Brazilian …, 2008 | 20 | 2008 |
| A structural model for chorismate synthase from Mycobacterium tuberculosis in complex with coenzyme and substrate CL Fernandes, A Breda, DS Santos, LA Basso, ON de Souza Computers in biology and medicine 37 (2), 149-158, 2007 | 19 | 2007 |
| Wild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS? A Breda, LKB Martinelli, CV Bizarro, LA Rosado, CB Borges, DS Santos, ... PLoS One 7 (6), e39245, 2012 | 15 | 2012 |
| UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation DC Rostirolla, A Breda, LA Rosado, MS Palma, LA Basso, DS Santos Archives of biochemistry and biophysics 505 (2), 202-212, 2011 | 15 | 2011 |
| Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine–Guanine Phosphoribosyltransferases K Glockzin, D Kostomiris, YVT Minnow, K Suthagar, K Clinch, S Gai, ... Biochemistry 61 (19), 2088-2105, 2022 | 12 | 2022 |
| Self-masked aldehyde inhibitors of human cathepsin L are potent anti-CoV-2 agents J Zhu, L Li, A Drelich, BC Chenna, DM Mellott, ZW Taylor, V Tat, ... Frontiers in chemistry 10, 867928, 2022 | 10 | 2022 |
| Dinitrosyl iron complexes (DNICs) as inhibitors of the SARS-CoV-2 main protease DC Pectol, CR DeLaney, J Zhu, DM Mellott, A Katzfuss, ZW Taylor, ... Chemical Communications 57 (67), 8352-8355, 2021 | 10 | 2021 |
| Ab initio 3-D structure prediction of an artificially designed three-α-helix bundle via all-atom molecular dynamics simulations A Breda, DS Santos, LA Basso, ON de Souza Genetics and Molecular Research 6 (4), 901-910, 2007 | 10 | 2007 |
| The conserved Lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenase VS Rodrigues, A Breda, DS Santos, LA Basso BMC Research Notes 2, 1-7, 2009 | 9 | 2009 |
Osmar Norberto de Souza - labio.osm...Head, Trunk, & Limbs - Laboratory for Bioinformatics, Modelling and Simulation of Biosystems - LABIO在 pucrs.br 的电子邮件经过验证
