The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic … JD Sauer, K Sotelo-Troha, J Von Moltke, KM Monroe, CS Rae, ... Infection and immunity 79 (2), 688-694, 2011 | 632 | 2011 |
Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol JD Sauer, CE Witte, J Zemansky, B Hanson, P Lauer, DA Portnoy Cell host & microbe 7 (5), 412-419, 2010 | 364 | 2010 |
The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function K Sureka, PH Choi, M Precit, M Delince, DA Pensinger, TAN Huynh, ... Cell 158 (6), 1389-1401, 2014 | 226 | 2014 |
An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence TAN Huynh, S Luo, D Pensinger, JD Sauer, L Tong, JJ Woodward Proceedings of the National Academy of Sciences 112 (7), E747-E756, 2015 | 208 | 2015 |
Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection CE Witte, AT Whiteley, TP Burke, JD Sauer, DA Portnoy, JJ Woodward MBio 4 (3), 10.1128/mbio. 00282-13, 2013 | 207 | 2013 |
Type I IFN signaling constrains IL-17A/F secretion by γδ T cells during bacterial infections T Henry, GS Kirimanjeswara, T Ruby, JW Jones, K Peng, M Perret, L Ho, ... The Journal of Immunology 184 (7), 3755-3767, 2010 | 187 | 2010 |
Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome VM Reyes Ruiz, J Ramirez, N Naseer, NM Palacio, IJ Siddarthan, BM Yan, ... Proceedings of the National Academy of Sciences 114 (50), 13242-13247, 2017 | 163 | 2017 |
Differential requirements for NAIP5 in activation of the NLRC4 inflammasome KL Lightfield, J Persson, NJ Trinidad, SW Brubaker, EM Kofoed, JD Sauer, ... Infection and immunity 79 (4), 1606-1614, 2011 | 158 | 2011 |
The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages JD Sauer, MA Bachman, MS Swanson Proceedings of the National Academy of Sciences 102 (28), 9924-9929, 2005 | 156 | 2005 |
Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity JD Sauer, S Pereyre, KA Archer, TP Burke, B Hanson, P Lauer, ... Proceedings of the National Academy of Sciences 108 (30), 12419-12424, 2011 | 148 | 2011 |
Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity CE Witte, KA Archer, CS Rae, JD Sauer, JJ Woodward, DA Portnoy Advances in immunology 113, 135-156, 2012 | 117 | 2012 |
Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish WJB Vincent, CM Freisinger, P Lam, A Huttenlocher, JD Sauer Cellular microbiology 18 (4), 591-604, 2016 | 81 | 2016 |
Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish V Miskolci, J Squirrell, J Rindy, W Vincent, JD Sauer, A Gibson, ... Elife 8, e45976, 2019 | 73 | 2019 |
The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence DA Pensinger, KM Boldon, GY Chen, WJB Vincent, K Sherman, M Xiong, ... PLoS pathogens 12 (11), e1006001, 2016 | 70 | 2016 |
Specificity of Legionella pneumophila and Coxiella burnetii Vacuoles and Versatility of Legionella pneumophila Revealed by Coinfection JD Sauer, JG Shannon, D Howe, SF Hayes, MS Swanson, RA Heinzen Infection and immunity 73 (8), 4494-4504, 2005 | 63 | 2005 |
Penicillin binding protein 1 is important in the compensatory response of Staphylococcus aureus to daptomycin-induced membrane damage and is a potential target for β-lactam … AD Berti, E Theisen, JD Sauer, P Nonejuie, J Olson, J Pogliano, ... Antimicrobial agents and chemotherapy 60 (1), 451-458, 2016 | 62 | 2016 |
Selective pharmacologic inhibition of a PASTA kinase increases Listeria monocytogenes susceptibility to β-lactam antibiotics DA Pensinger, MT Aliota, AJ Schaenzer, KM Boldon, IH Ansari, ... Antimicrobial agents and chemotherapy 58 (8), 4486-4494, 2014 | 62 | 2014 |
Do shoot the messenger: PASTA kinases as virulence determinants and antibiotic targets DA Pensinger, AJ Schaenzer, JD Sauer Trends in microbiology 26 (1), 56-69, 2018 | 61 | 2018 |
NAD (H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis M Ye, Y Zhao, Y Wang, R Xie, Y Tong, JD Sauer, S Gong Nature nanotechnology 17 (8), 880-890, 2022 | 56 | 2022 |
The phagosomal nutrient transporter (Pht) family DE Chen, S Podell, JD Sauer, MS Swanson, MH Saier Microbiology 154 (1), 42-53, 2008 | 50 | 2008 |