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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ... Immunity 39 (3), 443-453, 2013 | 1161 | 2013 |
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ... Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014 | 567 | 2014 |
A three-ring circus: Metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals A Parthasarathy, PJ Cross, RCJ Dobson, LE Adams, MA Savka, ... Frontiers in Molecular Biosciences 5, 29, 2018 | 266 | 2018 |
Bovine β-lactoglobulin is dimeric under imitative physiological conditions: dissociation equilibrium and rate constants over the pH range of 2.5–7.5 D Mercadante, LD Melton, GE Norris, TS Loo, MAK Williams, RCJ Dobson, ... Biophysical Journal 103 (2), 303-312, 2012 | 169 | 2012 |
Potential for bacteriophage endolysins to supplement or replace antibiotics in food production and clinical care MJ Love, D Bhandari, RCJ Dobson, C Billington Antibiotics 7 (1), 17, 2018 | 155 | 2018 |
Structural and functional analysis of the GABARAP interaction motif (GIM) VV Rogov, A Stolz, AC Ravichandran, DO Rios‐Szwed, H Suzuki, A Kniss, ... EMBO Reports 18 (8), 1382-1396, 2017 | 155 | 2017 |
The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad RCJ Dobson, K Valegård, JA Gerrard Journal of Molecular Biology 338 (2), 329-339, 2004 | 128 | 2004 |
Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism H Suzuki, K Tabata, E Morita, M Kawasaki, R Kato, RCJ Dobson, ... Structure 22 (1), 47-58, 2014 | 112 | 2014 |
Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen BR Burgess, RCJ Dobson, MF Bailey, SC Atkinson, MDW Griffin, ... Journal of Biological Chemistry 283 (41), 27598-27603, 2008 | 110 | 2008 |
Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation K Chen, J Hu, DL Moore, R Liu, SA Kessans, K Breslin, IS Lucet, A Keniry, ... Proceedings of the National Academy of Sciences 112 (27), E3535-E3544, 2015 | 108 | 2015 |
The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance RCJ Dobson, MDW Griffin, GB Jameson, JA Gerrard Acta Crystallographica Section D: Biological Crystallography 61 (8), 1116-1124, 2005 | 104 | 2005 |
The quest for novel antibiotics and antimicrobial compounds: Emerging trends in research, development and technologies PK Mantravadi, K Kalesh, RCJ Dobson, AO Hudson, A Parthasarathy Antibiotics 8 (1), 8, 2019 | 102 | 2019 |
Evolution of quaternary structure in a homotetrameric enzyme MDW Griffin, RCJ Dobson, FG Pearce, L Antonio, AE Whitten, CK Liew, ... Journal of Molecular Biology 380 (4), 691-703, 2008 | 96 | 2008 |
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis G Kefala, GL Evans, MDW Griffin, SRA Devenish, FG Pearce, MA Perugini, ... Biochemical Journal 411 (2), 351-360, 2008 | 87 | 2008 |
Chromatic Bacteria - A broad host-range plasmid and chromosomal insertion toolbox for fluorescent protein expression in bacteria RO Schlechter, H Jun, M Bernach, S Oso, EFJ Boyd, DA Muñoz-Lintz, ... Frontiers in Microbiology 9, 3052, 2018 | 83 | 2018 |
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site WY Wahlgren, E Dunevall, RA North, A Paz, M Scalise, P Bisignano, ... Nature Communications 9 (1), 1753, 2018 | 83 | 2018 |
Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis PJ Cross, RCJ Dobson, ML Patchett, EJ Parker Journal of Biological Chemistry 286 (12), 10216-10224, 2011 | 75 | 2011 |
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