| Genome-scale CRISPR-mediated control of gene repression and activation LA Gilbert, MA Horlbeck, B Adamson, JE Villalta, Y Chen, EH Whitehead, ... Cell 159 (3), 647-661, 2014 | 2777 | 2014 |
| A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response B Adamson, TM Norman, M Jost, MY Cho, JK Nuñez, Y Chen, JE Villalta, ... Cell 167 (7), 1867-1882. e21, 2016 | 993 | 2016 |
| Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation MA Horlbeck, LA Gilbert, JE Villalta, B Adamson, RA Pak, Y Chen, ... elife 5, e19760, 2016 | 732 | 2016 |
| CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells SJ Liu, MA Horlbeck, SW Cho, HS Birk, M Malatesta, D He, FJ Attenello, ... Science 355 (6320), eaah7111, 2017 | 729 | 2017 |
| CRISPR interference efficiently induces specific and reversible gene silencing in human iPSCs MA Mandegar, N Huebsch, EB Frolov, E Shin, A Truong, MP Olvera, ... Cell stem cell 18 (4), 541-553, 2016 | 531 | 2016 |
| Nucleosomes impede Cas9 access to DNA in vivo and in vitro MA Horlbeck, LB Witkowsky, B Guglielmi, JM Replogle, LA Gilbert, ... elife 5, e12677, 2016 | 428 | 2016 |
| A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility MC Bassik, M Kampmann, RJ Lebbink, S Wang, MY Hein, I Poser, ... Cell 152 (4), 909-922, 2013 | 420 | 2013 |
| Promoter of lncRNA gene PVT1 is a tumor-suppressor DNA boundary element SW Cho, J Xu, R Sun, MR Mumbach, AC Carter, YG Chen, KE Yost, J Kim, ... Cell 173 (6), 1398-1412. e22, 2018 | 418 | 2018 |
| Single-cell analysis of long non-coding RNAs in the developing human neocortex SJ Liu, TJ Nowakowski, AA Pollen, JH Lui, MA Horlbeck, FJ Attenello, ... Genome biology 17, 1-17, 2016 | 366 | 2016 |
| Mapping the genetic landscape of human cells MA Horlbeck, A Xu, M Wang, NK Bennett, CY Park, D Bogdanoff, ... Cell 174 (4), 953-967. e22, 2018 | 260 | 2018 |
| Combined CRISPRi/a-based chemical genetic screens reveal that rigosertib is a microtubule-destabilizing agent M Jost, Y Chen, LA Gilbert, MA Horlbeck, L Krenning, G Menchon, A Rai, ... Molecular cell 68 (1), 210-223. e6, 2017 | 226 | 2017 |
| Exploring genetic interaction manifolds constructed from rich single-cell phenotypes TM Norman, MA Horlbeck, JM Replogle, AY Ge, A Xu, M Jost, LA Gilbert, ... Science 365 (6455), 786-793, 2019 | 203 | 2019 |
| Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification RM Deans, DW Morgens, A Ökesli, S Pillay, MA Horlbeck, M Kampmann, ... Nature chemical biology 12 (5), 361-366, 2016 | 174 | 2016 |
| ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p A Čopič, CF Latham, MA Horlbeck, JG D’Arcangelo, EA Miller Science 335 (6074), 1359-1362, 2012 | 163 | 2012 |
| Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs M Jost, DA Santos, RA Saunders, MA Horlbeck, JS Hawkins, SM Scaria, ... Nature biotechnology 38 (3), 355-364, 2020 | 122 | 2020 |
| Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation CJ Braun, PM Bruno, MA Horlbeck, LA Gilbert, JS Weissman, MT Hemann Proceedings of the National Academy of Sciences 113 (27), E3892-E3900, 2016 | 113 | 2016 |
| Next-generation libraries for robust RNA interference-based genome-wide screens M Kampmann, MA Horlbeck, Y Chen, JC Tsai, MC Bassik, LA Gilbert, ... Proceedings of the National Academy of Sciences 112 (26), E3384-E3391, 2015 | 107 | 2015 |
| CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma SJ Liu, M Malatesta, BV Lien, P Saha, SS Thombare, SJ Hong, L Pedraza, ... Genome biology 21, 1-18, 2020 | 95 | 2020 |
| Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins AJ Martinko, C Truillet, O Julien, JE Diaz, MA Horlbeck, G Whiteley, ... Elife 7, e31098, 2018 | 87 | 2018 |
| Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform KJ Wangensteen, YJ Wang, Z Dou, AW Wang, E Mosleh‐Shirazi, ... Hepatology 68 (2), 663-676, 2018 | 74 | 2018 |
