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Tobias Kroon, PhD
Tobias Kroon, PhD
Metabolism Bioscience, CVRM, AstraZeneca R&D
在 astrazeneca.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
PPARγ and PPARα synergize to induce robust browning of white fat in vivo
T Kroon, M Harms, S Maurer, L Bonnet, I Alexandersson, A Lindblom, ...
Molecular metabolism 36, 100964, 2020
632020
The SGLT2 inhibitor dapagliflozin promotes systemic FFA mobilization, enhances hepatic β-oxidation, and induces ketosis
K Wallenius, T Kroon, T Hagstedt, L Löfgren, M Sörhede-Winzell, ...
Journal of lipid research 63 (3), 2022
412022
BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice
JM Hoffmann, JR Grünberg, A Hammarstedt, T Kroon, TU Greiner, ...
Molecular metabolism 32, 15-26, 2020
232020
In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects
V Osinski, DK Bauknight, SSK Dasa, MJ Harms, T Kroon, MA Marshall, ...
Theranostics 10 (2), 585, 2020
222020
Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats [S]
T Kroon, T Baccega, A Olsén, J Gabrielsson, ND Oakes
Journal of lipid research 58 (1), 31-41, 2017
222017
Feedback modeling of non-esterified fatty acids in obese Zucker rats after nicotinic acid infusions
C Ahlström, T Kroon, LA Peletier, J Gabrielsson
Journal of pharmacokinetics and pharmacodynamics 40, 623-638, 2013
172013
Dosing profile profoundly influences nicotinic acid's ability to improve metabolic control in rats
T Kroon, A Kjellstedt, P Thalén, J Gabrielsson, ND Oakes
Journal of Lipid Research 56 (9), 1679-1690, 2015
162015
Cellular senescence in hepatocytes contributes to metabolic disturbances in NASH
L Bonnet, I Alexandersson, RK Baboota, T Kroon, J Oscarsson, U Smith, ...
Frontiers in Endocrinology 13, 957616, 2022
152022
Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments
R Andersson, T Kroon, J Almquist, M Jirstrand, ND Oakes, ND Evans, ...
Journal of Pharmacokinetics and Pharmacodynamics 44 (3), 203-222, 2017
142017
Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats
T Kroon, T Hagstedt, I Alexandersson, A Ferm, M Petersson, S Maurer, ...
Science Translational Medicine 14 (668), eabh1316, 2022
72022
Mitochondrial amidoxime‐reducing component 1 p. Ala165Thr increases protein degradation mediated by the proteasome
T Dutta, K Sasidharan, E Ciociola, G Pennisi, FR Noto, L Kovooru, ...
Liver International 44 (5), 1219-1232, 2024
62024
Optimizing nicotinic acid delivery for durable antilipolysis and improved metabolic control
P Kroon, T Kroon
Acta Universitatis Agriculturae Sueciae, 2016
22016
1881-P: The SGLT2 Inhibitor Dapagliflozin Improves Glucose Control and Enhances Liver Fatty Acid Oxidation and Ketone Body Formation in Insulin Resistant Obese Zucker Rats
T KROON, T HAGSTEDT, ANN KJELLSTEDT, A LINDBLOM, L LÖFGREN, ...
Diabetes 68 (Supplement_1), 2019
12019
193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats
T Kroon, T Hagstedt, I Alexandersson, A Ferm, M Petersson, S Maurer, ...
Diabetes 71 (Supplement_1), 2022
2022
BMP4 gene therapy delays diabetes progression in the diabetic db/db mouse model
RK Shahidi, LM Holm, L Bonnet, T Kroon, D Nilsson, A Ahnmark, I Elias, ...
DIABETOLOGIA 62, S122-S122, 2019
2019
1953-P: PPARγ Agonism and FGF-21 Synergize to Robustly Induce Browning of White Fat
T Kroon, MJ Harms, D Nilsson, A Lindblom, P Gennemark, G O'MAHONY, ...
Diabetes 68 (Supplement_1), 2019
2019
The dual PPAR alpha/gamma-agonist tesaglitazar robustly induces browning of white fat in vitro and in vivo
T Kroon, M Harms, D Nilsson, A Lindblom, P Gennemark, G O'Mahony, ...
DIABETOLOGIA 61, S102-S102, 2018
2018
The abruptness of terminating nicotinic acid delivery has a profound effect on free fatty acid and insulin rebound in rats
T Kroon, J Gabrielsson, ND Oakes
DIABETOLOGIA 58, S568-S568, 2015
2015
Intermittent, but Not Continuous, Nicotinic Acid (NiAc) Infusion Preserves Plasma Free Fatty Acid (FFA) Lowering and Ameliorates Insulin Resistance in Obese Zucker Rats
T Kroon, P Thalen, A Kjellstedt, J Gabrielsson, ND Oakes
DIABETES 63, A470-A470, 2014
2014
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