| Regulatory mechanisms in T cell receptor signalling G Gaud, R Lesourne, PE Love Nature Reviews Immunology 18 (8), 485-497, 2018 | 521 | 2018 |
| Themis, a T cell–specific protein important for late thymocyte development R Lesourne, S Uehara, J Lee, KD Song, LQ Li, J Pinkhasov, Y Zhang, ... Nature immunology 10 (8), 840-847, 2009 | 170 | 2009 |
| Negative signaling in Fc receptor complexes M Daëron, R Lesourne Advances in immunology 89, 39-86, 2006 | 103 | 2006 |
| THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1 S Choi, C Warzecha, E Zvezdova, J Lee, J Argenty, R Lesourne, ... Nature immunology 18 (4), 433-441, 2017 | 85 | 2017 |
| Two distinct tyrosine-based motifs enable the inhibitory receptor FcγRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap I Isnardi, R Lesourne, P Bruhns, WH Fridman, JC Cambier, M Daëron Journal of Biological Chemistry 279 (50), 51931-51938, 2004 | 70 | 2004 |
| Linker for activation of T cells integrates positive and negative signaling in mast cells O Malbec, M Malissen, I Isnardi, R Lesourne, AM Mura, WH Fridman, ... The Journal of Immunology 173 (8), 5086-5094, 2004 | 61 | 2004 |
| Insufficient phosphorylation prevents FcγRIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1 R Lesourne, P Bruhns, WH Fridman, M Daëron Journal of Biological Chemistry 276 (9), 6327-6336, 2001 | 56 | 2001 |
| Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease SJ Hwang, KD Song, R Lesourne, J Lee, J Pinkhasov, LQ Li, D El-Khoury, ... Journal of Experimental Medicine 209 (10), 1781-1795, 2012 | 55 | 2012 |
| Dynamic interactions of Fcγ receptor IIB with filamin-bound SHIP1 amplify filamentous actin-dependent negative regulation of Fcε receptor I signaling R Lesourne, WH Fridman, M Daëron The Journal of Immunology 174 (3), 1365-1373, 2005 | 52 | 2005 |
| Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability E Zvezdova, J Mikolajczak, A Garreau, M Marcellin, L Rigal, J Lee, S Choi, ... Science signaling 9 (428), ra51-ra51, 2016 | 41 | 2016 |
| Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function R Lesourne, E Zvezdova, KD Song, D El-Khoury, S Uehara, VA Barr, ... The Journal of Immunology 189 (3), 1154-1161, 2012 | 41 | 2012 |
| TCR ITAM multiplicity is required for the generation of follicular helper T-cells SJ Hwang, AC Palin, LQ Li, KD Song, J Lee, J Herz, N Tubo, H Chu, ... Nature communications 6 (1), 6982, 2015 | 40 | 2015 |
| Thpok‐independent repression of Runx3 by Gata3 during CD4+ T‐cell differentiation in the thymus Y Xiong, E Castro, R Yagi, J Zhu, R Lesourne, PE Love, L Feigenbaum, ... European journal of immunology 43 (4), 918-928, 2013 | 37 | 2013 |
| Themis2 lowers the threshold for B cell activation during positive selection D Cheng, M Deobagkar-Lele, E Zvezdova, S Choi, S Uehara, D Baup, ... Nature immunology 18 (2), 205-213, 2017 | 30 | 2017 |
| THEMIS: two models, different thresholds S Choi, R Cornall, R Lesourne, PE Love Trends in immunology 38 (9), 622-632, 2017 | 27 | 2017 |
| Proteomic analysis of regulatory T cells reveals the importance of Themis1 in the control of their suppressive function F Duguet, M Locard-Paulet, M Marcellin, K Chaoui, I Bernard, ... Molecular & Cellular Proteomics 16 (8), 1416-1432, 2017 | 26 | 2017 |
| An epistatic interaction between Themis1 and Vav1 modulates regulatory T cell function and inflammatory bowel disease development C Pedros, G Gaud, I Bernard, S Kassem, M Chabod, D Lagrange, ... The Journal of Immunology 195 (4), 1608-1616, 2015 | 23 | 2015 |
| CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens G Blaize, H Daniels-Treffandier, M Aloulou, N Rouquié, C Yang, ... Proceedings of the National Academy of Sciences 117 (23), 12969-12979, 2020 | 22 | 2020 |
| Grb2-mediated recruitment of USP9X to LAT enhances themis stability following thymic selection A Garreau, G Blaize, J Argenty, N Rouquié, A Tourdès, SA Wood, ... The Journal of Immunology 199 (8), 2758-2766, 2017 | 13 | 2017 |
| Negative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses S Mélique, C Yang, R Lesourne biomedical journal 45 (2), 334-346, 2022 | 8 | 2022 |
