Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent DJ Boocock, GES Faust, KR Patel, AM Schinas, VA Brown, MP Ducharme, ... Cancer Epidemiology Biomarkers & Prevention 16 (6), 1246-1252, 2007 | 1018 | 2007 |
Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model JF Marier, P Vachon, A Gritsas, J Zhang, JP Moreau, MP Ducharme Journal of pharmacology and experimental therapeutics 302 (1), 369-373, 2002 | 572 | 2002 |
Disposition of intravenous and oral cyclosporine after administration with grapefruit juice MP Ducharme, LH Warbasse, DJ Edwards Clinical Pharmacology & Therapeutics 57 (5), 485-491, 1995 | 444 | 1995 |
6′, 7′‐Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P‐glycoprotein DJ Edwards, ME Fitzsimmons, EG Schuetz, K Yasuda, MP Ducharme, ... Clinical Pharmacology & Therapeutics 65 (3), 237-244, 1999 | 323 | 1999 |
A review of the pharmacokinetics of levothyroxine for the treatment of hypothyroidism P Colucci, CS Yue, M Ducharme, S Benvenga European endocrinology 9 (1), 40, 2013 | 196 | 2013 |
Vancomycin pharmacokinetics in a patient population: effect of age, gender, and body weight MP Ducharme, RL Slaughter, DJ Edwards Therapeutic drug monitoring 16 (5), 513-518, 1994 | 165 | 1994 |
The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein MP Di Marco, DJ Edwards, IW Wainer, MP Ducharme Life sciences 71 (10), 1149-1160, 2002 | 154 | 2002 |
Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans J Grenier, C Fradette, G Morelli, GJ Merritt, M Vranderick, MP Ducharme Clinical Pharmacology & Therapeutics 79 (3), 255-262, 2006 | 141 | 2006 |
Trough concentrations of cyclosporine in blood following administration with grapefruit juice MP DUCHARME, R PROVENZANO, M DEHOORNE‐SMITH, ... British journal of clinical pharmacology 36 (5), 457-459, 1993 | 128 | 1993 |
Liposomal tobramycin against pulmonary infections of Pseudomonas aeruginosa: a pharmacokinetic and efficacy study following single and multiple intratracheal … JF Marier, JL Brazier, J Lavigne, MP Ducharme Journal of antimicrobial chemotherapy 52 (2), 247-252, 2003 | 110 | 2003 |
Phase I and pharmacokinetic study of DE-310 in patients with advanced solid tumors O Soepenberg, MJA De Jonge, A Sparreboom, P De Bruin, FALM Eskens, ... Clinical cancer research 11 (2), 703-711, 2005 | 104 | 2005 |
Itraconazole and hydroxyitraconazole serum concentrations are reduced more than tenfold by phenytoin MP Ducharme, RL Slaughter, LH Warbasse, PH Chandrasekar, ... Clinical Pharmacology & Therapeutics 58 (6), 617-624, 1995 | 92 | 1995 |
Pharmacokinetics and potential advantages of a new oral solution of levothyroxine vs. other available dosage forms CS Yue, C Scarsi, MP Ducharme Arzneimittelforschung 62 (12), 631-636, 2012 | 91 | 2012 |
Pharmacokinetics and efficacies of liposomal and conventional formulations of tobramycin after intratracheal administration in rats with pulmonary Burkholderia cepacia infection JF Marier, J Lavigne, MP Ducharme Antimicrobial agents and chemotherapy 46 (12), 3776-3781, 2002 | 81 | 2002 |
A population pharmacokinetic model for vancomycin in pediatric patients and its predictive value in a naive population P Lamarre, D Lebel, MP Ducharme Antimicrobial agents and chemotherapy 44 (2), 278-282, 2000 | 65 | 2000 |
Drug-induced alterations in serum creatinine concentrations EA Hartshorn, MP Ducharme, M Smythe, G Strohs Annals of Pharmacotherapy 27 (5), 622-633, 1993 | 63 | 1993 |
Harmonization of regulatory approaches for evaluating therapeutic equivalence and interchangeability of multisource drug products: workshop summary report ML Chen, VP Shah, DJ Crommelin, L Shargel, D Bashaw, M Bhatti, ... European journal of pharmaceutical sciences 44 (4), 506-513, 2011 | 56 | 2011 |
DX‐8951f: summary of Phase I clinical trials R De Jager, P Cheverton, K Tamanoi, J Coyle, M Ducharme, N Sakamoto, ... Annals of the New York Academy of Sciences 922 (1), 260-273, 2000 | 55 | 2000 |
Enantioselective disposition of hydroxychloroquine after a single oral dose of the racemate to healthy subjects [see comments] J Ducharme, H Fieger, MP Ducharme, SK Khalil, IW Wainer British journal of clinical pharmacology 40 (2), 127-133, 1995 | 54 | 1995 |
Role of pharmacokinetics in establishing bioequivalence for orally inhaled drug products: workshop summary report D O'Connor, WP Adams, ML Chen, P Daley-Yates, J Davis, H Derendorf, ... Journal of aerosol medicine and pulmonary drug delivery 24 (3), 119-135, 2011 | 48 | 2011 |