RAD51 Gene Family Structure and Function B Bonilla, SR Hengel, MKK Grundy, KA Bernstein Annual review of genetics 54 (1), 25-46, 2020 | 150 | 2020 |
Small-molecule inhibitors targeting DNA repair and DNA repair deficiency in research and cancer therapy SR Hengel, MA Spies, M Spies Cell chemical biology 24 (9), 1101-1119, 2017 | 144 | 2017 |
Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells SR Hengel, E Malacaria, L Folly da Silva Constantino, FE Bain, A Diaz, ... Elife 5, e14740, 2016 | 79 | 2016 |
Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E J Zhang, PJ Sapienza, H Ke, A Chang, SR Hengel, H Wang, ... Biochemistry 49 (43), 9280-9291, 2010 | 73 | 2010 |
Mismatch repair protein hMSH2–hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate M Honda, Y Okuno, SR Hengel, JV Martín-López, CP Cook, ... Proceedings of the National Academy of Sciences 111 (3), E316-E325, 2014 | 47 | 2014 |
Folly da Silva Constantino SR Hengel, E Malacaria L., Bain, FE, Diaz, A., Koch, BG, Yu, L., Wu, M., Pichierri, P., Spies, MA …, 2016 | 45 | 2016 |
DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs B Stefanovie, SR Hengel, J Mlcouskova, J Prochazkova, M Spirek, ... Nucleic acids research 48 (2), 694-708, 2020 | 32 | 2020 |
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway JC Rosenbaum, B Bonilla, SR Hengel, TM Mertz, BW Herken, ... Nature communications 10 (1), 3515, 2019 | 30 | 2019 |
Distinct roles for conformational dynamics in protein-ligand interactions X Liu, DC Speckhard, TR Shepherd, YJ Sun, SR Hengel, L Yu, CA Fowler, ... Structure 24 (12), 2053-2066, 2016 | 30 | 2016 |
Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors DS Bhat, E Malacaria, LD Biagi, M Razzaghi, M Honda, KF Hobbs, ... NAR cancer 5 (2), zcad018, 2023 | 5 | 2023 |
The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions B Bonilla, AJ Brown, SR Hengel, KS Rapchak, D Mitchell, CA Pressimone, ... Elife 10, e68080, 2021 | 5 | 2021 |
Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity L Wan, S Toland, LR Robinson-McCarthy, N Lee, MA Schaich, SR Hengel, ... Proceedings of the National Academy of Sciences 120 (30), e2308010120, 2023 | 4 | 2023 |
Analysis of NIH K99/R00 awards and the career progression of awardees NC Woitowich, SR Hengel, C Solis, TP Vilgalys, J Babdor, DJ Tyrrell Elife 12, RP88984, 2024 | 1 | 2024 |
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA. SR Hengel, K Oppenheimer, C Smith, M Schaich, HL Rein, J Martino, ... bioRxiv, 2024.02. 14.580393, 2024 | 1 | 2024 |
Analysis of NIH Biomedical Faculty K99 Awards, Transitions, and R00 Outcomes NC Woitowich, SR Hengel, TP Vilgalys, J Babdor, DJ Tyrrell bioRxiv, 2023.01. 26.525751, 2023 | | 2023 |
SWSAP1-SWS1 Stimulates D-Loop Formation on RPA-Coated SsDNA SR Hengel, KG Oppenheimer, K Bernstein ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 63, 80-80, 2022 | | 2022 |
Genetic Determinants of Disease Risk from Environmental DNA Damage. S Hengel, C Smith, K Bernstein ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 62, 45-45, 2021 | | 2021 |
The BRCA2-interacting Protein, PDS5B, and SPIDR are Novel Shu Complex Components. SR Hengel, J Martino, G Brunette, J Barroso-Gonzales, T Moiseeva, ... ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 61, 77-77, 2020 | | 2020 |
HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies MA Spies, M Spies, SR Hengel US Patent App. 15/745,587, 2018 | | 2018 |
Dissecting RAD52 function in DNA repair SR Hengel University of Iowa, 2017 | | 2017 |