关注
Sarah R. Hengel
Sarah R. Hengel
University of Pittsburgh, Hillman Cancer Center
在 pitt.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
RAD51 Gene Family Structure and Function
B Bonilla, SR Hengel, MKK Grundy, KA Bernstein
Annual review of genetics 54 (1), 25-46, 2020
1502020
Small-molecule inhibitors targeting DNA repair and DNA repair deficiency in research and cancer therapy
SR Hengel, MA Spies, M Spies
Cell chemical biology 24 (9), 1101-1119, 2017
1442017
Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells
SR Hengel, E Malacaria, L Folly da Silva Constantino, FE Bain, A Diaz, ...
Elife 5, e14740, 2016
792016
Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E
J Zhang, PJ Sapienza, H Ke, A Chang, SR Hengel, H Wang, ...
Biochemistry 49 (43), 9280-9291, 2010
732010
Mismatch repair protein hMSH2–hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate
M Honda, Y Okuno, SR Hengel, JV Martín-López, CP Cook, ...
Proceedings of the National Academy of Sciences 111 (3), E316-E325, 2014
472014
Folly da Silva Constantino
SR Hengel, E Malacaria
L., Bain, FE, Diaz, A., Koch, BG, Yu, L., Wu, M., Pichierri, P., Spies, MA …, 2016
452016
DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs
B Stefanovie, SR Hengel, J Mlcouskova, J Prochazkova, M Spirek, ...
Nucleic acids research 48 (2), 694-708, 2020
322020
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway
JC Rosenbaum, B Bonilla, SR Hengel, TM Mertz, BW Herken, ...
Nature communications 10 (1), 3515, 2019
302019
Distinct roles for conformational dynamics in protein-ligand interactions
X Liu, DC Speckhard, TR Shepherd, YJ Sun, SR Hengel, L Yu, CA Fowler, ...
Structure 24 (12), 2053-2066, 2016
302016
Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors
DS Bhat, E Malacaria, LD Biagi, M Razzaghi, M Honda, KF Hobbs, ...
NAR cancer 5 (2), zcad018, 2023
52023
The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions
B Bonilla, AJ Brown, SR Hengel, KS Rapchak, D Mitchell, CA Pressimone, ...
Elife 10, e68080, 2021
52021
Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity
L Wan, S Toland, LR Robinson-McCarthy, N Lee, MA Schaich, SR Hengel, ...
Proceedings of the National Academy of Sciences 120 (30), e2308010120, 2023
42023
Analysis of NIH K99/R00 awards and the career progression of awardees
NC Woitowich, SR Hengel, C Solis, TP Vilgalys, J Babdor, DJ Tyrrell
Elife 12, RP88984, 2024
12024
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.
SR Hengel, K Oppenheimer, C Smith, M Schaich, HL Rein, J Martino, ...
bioRxiv, 2024.02. 14.580393, 2024
12024
Analysis of NIH Biomedical Faculty K99 Awards, Transitions, and R00 Outcomes
NC Woitowich, SR Hengel, TP Vilgalys, J Babdor, DJ Tyrrell
bioRxiv, 2023.01. 26.525751, 2023
2023
SWSAP1-SWS1 Stimulates D-Loop Formation on RPA-Coated SsDNA
SR Hengel, KG Oppenheimer, K Bernstein
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 63, 80-80, 2022
2022
Genetic Determinants of Disease Risk from Environmental DNA Damage.
S Hengel, C Smith, K Bernstein
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 62, 45-45, 2021
2021
The BRCA2-interacting Protein, PDS5B, and SPIDR are Novel Shu Complex Components.
SR Hengel, J Martino, G Brunette, J Barroso-Gonzales, T Moiseeva, ...
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 61, 77-77, 2020
2020
HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies
MA Spies, M Spies, SR Hengel
US Patent App. 15/745,587, 2018
2018
Dissecting RAD52 function in DNA repair
SR Hengel
University of Iowa, 2017
2017
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