The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks AAE Ali, G Timinszky, R Arribas-Bosacoma, M Kozlowski, PO Hassa, ... Nature structural & molecular biology 19 (7), 685-692, 2012 | 315 | 2012 |
Structural basis for recruitment of BRCA2 by PALB2 AW Oliver, S Swift, CJ Lord, A Ashworth, LH Pearl EMBO reports 10 (9), 990-996, 2009 | 211 | 2009 |
Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans D Boos, L Sanchez-Pulido, M Rappas, LH Pearl, AW Oliver, CP Ponting, ... Current Biology 21 (13), 1152-1157, 2011 | 187 | 2011 |
Crystal structure of the catalytic fragment of murine poly (ADP‐ribose) polymerase‐2 AW Oliver, JC Amé, SM Roe, V Good, G de Murcia, LH Pearl Nucleic acids research 32 (2), 456-464, 2004 | 181 | 2004 |
APLF promotes the assembly and activity of non‐homologous end joining protein complexes GJ Grundy, SL Rulten, Z Zeng, R Arribas‐Bosacoma, N Iles, K Manley, ... The EMBO journal 32 (1), 112-125, 2013 | 178 | 2013 |
Activation segment dimerization: a mechanism for kinase autophosphorylation of non‐consensus sites ACW Pike, P Rellos, FH Niesen, A Turnbull, AW Oliver, SA Parker, ... The EMBO journal 27 (4), 704-714, 2008 | 178 | 2008 |
Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange AW Oliver, A Paul, KJ Boxall, SE Barrie, GW Aherne, MD Garrett, ... The EMBO journal 25 (13), 3179-3190, 2006 | 156 | 2006 |
TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways CP Wardlaw, AM Carr, AW Oliver DNA repair 22, 165-174, 2014 | 127 | 2014 |
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors VE Anderson, MI Walton, PD Eve, KJ Boxall, L Antoni, JJ Caldwell, ... Cancer research 71 (2), 463-472, 2011 | 119 | 2011 |
The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function C Breslin, P Hornyak, A Ridley, SL Rulten, H Hanzlikova, AW Oliver, ... Nucleic acids research 43 (14), 6934-6944, 2015 | 116 | 2015 |
MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis PA Leimbacher, SE Jones, AMK Shorrocks, M de Marco Zompit, M Day, ... Molecular cell 74 (3), 571-583. e8, 2019 | 107 | 2019 |
Activation segment exchange: a common mechanism of kinase autophosphorylation? AW Oliver, S Knapp, LH Pearl Trends in biochemical sciences 32 (8), 351-356, 2007 | 105 | 2007 |
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity JR Becker, R Cuella-Martin, M Barazas, R Liu, C Oliveira, AW Oliver, ... Nature communications 9 (1), 5406, 2018 | 96 | 2018 |
Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA K Zabrady, M Adamus, L Vondrova, C Liao, H Skoupilova, M Novakova, ... Nucleic acids research 44 (3), 1064-1079, 2016 | 93 | 2016 |
Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease SN Van Der Crabben, MP Hennus, GA McGregor, DI Ritter, ... The Journal of clinical investigation 126 (8), 2881-2892, 2016 | 88 | 2016 |
Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 M Rappas, AW Oliver, LH Pearl Nucleic acids research 39 (1), 313-324, 2011 | 88 | 2011 |
Structure of an archaeal PCNA1–PCNA2–FEN1 complex: elucidating PCNA subunit and client enzyme specificity AS Dore, ML Kilkenny, SA Jones, AW Oliver, SM Roe, SD Bell, LH Pearl Nucleic Acids Research 34 (16), 4515-4526, 2006 | 87 | 2006 |
Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK AAE Ali, RM Jukes, LH Pearl, AW Oliver Nucleic acids research 37 (5), 1701-1712, 2009 | 84 | 2009 |
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2 GJ Grundy, LM Polo, Z Zeng, SL Rulten, NC Hoch, P Paomephan, Y Xu, ... Nature communications 7 (1), 12404, 2016 | 80 | 2016 |
Efficient single-strand break repair requires binding to both poly (ADP-ribose) and DNA by the central BRCT domain of XRCC1 LM Polo, Y Xu, P Hornyak, F Garces, Z Zeng, R Hailstone, SJ Matthews, ... Cell reports 26 (3), 573-581. e5, 2019 | 77 | 2019 |