The aged niche disrupts muscle stem cell quiescence JV Chakkalakal, KM Jones, MA Basson, AS Brack Nature 490 (7420), 355-360, 2012 | 877 | 2012 |
Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice JV Chakkalakal, MA Harrison, S Carbonetto, E Chin, RN Michel, ... Human molecular genetics 13 (4), 379-388, 2004 | 174 | 2004 |
Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling JV Chakkalakal, MA Stocksley, MA Harrison, LM Angus, ... Proceedings of the National Academy of Sciences 100 (13), 7791-7796, 2003 | 169 | 2003 |
Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies JV Chakkalakal, J Thompson, RJ Parks, BJ Jasmin The FASEB Journal 19 (8), 880-891, 2005 | 166 | 2005 |
Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration W Liu, A Klose, S Forman, ND Paris, L Wei-LaPierre, M Cortes-Lopez, ... Elife 6, e26464, 2017 | 152 | 2017 |
Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state JV Chakkalakal, J Christensen, W Xiang, MT Tierney, FS Boscolo, ... Development 141 (8), 1649-1659, 2014 | 149 | 2014 |
Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions W Liu, L Wei-LaPierre, A Klose, RT Dirksen, JV Chakkalakal elife 4, e09221, 2015 | 132 | 2015 |
Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons JV Chakkalakal, H Nishimune, JL Ruas, BM Spiegelman, JR Sanes Development 137 (20), 3489-3499, 2010 | 123 | 2010 |
Pharmacological activation of PPARβ/δ stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice P Miura, JV Chakkalakal, L Boudreault, G Belanger, RL Hébert, ... Human molecular genetics 18 (23), 4640-4649, 2009 | 123 | 2009 |
Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF‐AT pathway SJG St‐Pierre, JV Chakkalakal, SM Kolodziejczyk, JC Knudson, ... The FASEB journal 18 (15), 1937-1939, 2004 | 123 | 2004 |
Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution JF Bachman, A Klose, W Liu, ND Paris, RS Blanc, M Schmalz, E Knapp, ... Development 145 (20), dev167197, 2018 | 119 | 2018 |
Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events AO Gramolini, G Bélanger, JM Thompson, JV Chakkalakal, BJ Jasmin American Journal of Physiology-Cell Physiology 281 (4), C1300-C1309, 2001 | 108 | 2001 |
Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1α, drives utrophin gene expression at the neuromuscular junction LM Angus, JV Chakkalakal, A Méjat, JK Eibl, G Bélanger, LA Megeney, ... American Journal of Physiology-Cell Physiology 289 (4), C908-C917, 2005 | 99 | 2005 |
Targeted inhibition of Ca2+/calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle JV Chakkalakal, SA Michel, ER Chin, RN Michel, BJ Jasmin Human molecular genetics 15 (9), 1423-1435, 2006 | 83 | 2006 |
Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression RN Michel, ER Chin, JV Chakkalakal, JK Eibl, BJ Jasmin Applied Physiology, Nutrition, and Metabolism 32 (5), 921-929, 2007 | 79 | 2007 |
The utrophin A 5′-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers P Miura, J Thompson, JV Chakkalakal, M Holcik, BJ Jasmin Journal of Biological Chemistry 280 (38), 32997-33005, 2005 | 63 | 2005 |
The composition, development, and regeneration of neuromuscular junctions W Liu, JV Chakkalakal Current topics in developmental biology 126, 99-124, 2018 | 61 | 2018 |
Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling JV Chakkalakal, P Miura, G Belanger, RN Michel, BJ Jasmin Nucleic acids research 36 (3), 826-838, 2008 | 59 | 2008 |
Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury RS Blanc, JG Kallenbach, JF Bachman, A Mitchell, ND Paris, ... Nature Communications 11 (1), 4167, 2020 | 51 | 2020 |
Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy BJ Jasmin, LM Angus, G Bélanger, JV Chakkalakal, AO Gramolini, ... Journal of Physiology-Paris 96 (1-2), 31-42, 2002 | 43 | 2002 |