| Evolved Cas9 variants with broad PAM compatibility and high DNA specificity JH Hu, SM Miller, MH Geurts, W Tang, L Chen, N Sun, CM Zeina, X Gao, ... Nature 556 (7699), 57-63, 2018 | 1571 | 2018 |
| Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles M Wang, JA Zuris, F Meng, H Rees, S Sun, P Deng, Y Han, X Gao, ... Proceedings of the National Academy of Sciences 113 (11), 2868-2873, 2016 | 618 | 2016 |
| Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents X Gao, Y Tao, V Lamas, M Huang, WH Yeh, B Pan, YJ Hu, JH Hu, ... Nature 553 (7687), 217-221, 2018 | 544 | 2018 |
| The role of distant mutations and allosteric regulation on LovD active site dynamics G Jiménez-Osés, S Osuna, X Gao, MR Sawaya, L Gilson, SJ Collier, ... Nature chemical biology 10 (6), 431-436, 2014 | 210 | 2014 |
| Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain X Gao, SW Haynes, BD Ames, P Wang, LP Vien, CT Walsh, Y Tang Nature chemical biology 8 (10), 823-830, 2012 | 200 | 2012 |
| Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum X Gao, YH Chooi, BD Ames, P Wang, CT Walsh, Y Tang Journal of the American Chemical Society 133 (8), 2729-2741, 2011 | 144 | 2011 |
| Directed evolution and structural characterization of a simvastatin synthase X Gao, X Xie, I Pashkov, MR Sawaya, J Laidman, W Zhang, R Cacho, ... Chemistry & biology 16 (10), 1064-1074, 2009 | 124 | 2009 |
| Engineered polyketide biosynthesis and biocatalysis in Escherichia coli X Gao, P Wang, Y Tang Applied microbiology and biotechnology 88, 1233-1242, 2010 | 105 | 2010 |
| Uncovering the Enzymes that Catalyze the Final Steps in Oxytetracycline Biosynthesis P Wang, G Bashiri, X Gao, MR Sawaya, Y Tang Journal of the American Chemical Society 135 (19), 7138-7141, 2013 | 102 | 2013 |
| Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy T Wan, Y Chen, Q Pan, X Xu, Y Kang, X Gao, F Huang, C Wu, Y Ping Journal of Controlled Release 322, 236-247, 2020 | 99 | 2020 |
| Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome-and transcriptome-wide off-target effects S Lee, N Ding, Y Sun, T Yuan, J Li, Q Yuan, L Liu, J Yang, Q Wang, ... Science Advances 6 (29), eaba1773, 2020 | 79 | 2020 |
| Short Pathways to Complexity Generation: Fungal Peptidyl Alkaloid Multicyclic Scaffolds from Anthranilate Building Blocks CT Walsh, SW Haynes, BD Ames, X Gao, Y Tang ACS chemical biology 8 (7), 1366-1382, 2013 | 74 | 2013 |
| Amplification‐Free Detection of SARS‐CoV‐2 and Respiratory Syncytial Virus Using CRISPR Cas13a and Graphene Field‐Effect Transistors H Li, J Yang, G Wu, Z Weng, Y Song, Y Zhang, JA Vanegas, L Avery, ... Angewandte Chemie 134 (32), e202203826, 2022 | 68 | 2022 |
| Assembly of Asperlicin Peptidyl Alkaloids from Anthranilate and Tryptophan: A Two-Enzyme Pathway Generates Heptacyclic Scaffold Complexity in Asperlicin E SW Haynes, X Gao, Y Tang, CT Walsh Journal of the American Chemical Society 134 (42), 17444-17447, 2012 | 65 | 2012 |
| Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from … BD Ames, SW Haynes, X Gao, BS Evans, NL Kelleher, Y Tang, CT Walsh Biochemistry 50 (40), 8756-8769, 2011 | 62 | 2011 |
| Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin SW Haynes, X Gao, Y Tang, CT Walsh ACS Chemical Biology, 2013 | 61 | 2013 |
| Heterologous expression and manipulation of three tetracycline biosynthetic pathways P Wang, W Kim, LB Pickens, X Gao, Y Tang Angewandte Chemie (International ed. in English) 51 (44), 11136, 2012 | 58 | 2012 |
| Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole‐cell biocatalytic activity X Xie, I Pashkov, X Gao, JL Guerrero, TO Yeates, Y Tang Biotechnology and bioengineering 102 (1), 20-28, 2009 | 57 | 2009 |
| Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites SW Haynes, BD Ames, X Gao, Y Tang, CT Walsh Biochemistry 50 (25), 5668-5679, 2011 | 55 | 2011 |
| A dual-plasmid CRISPR/cas system for mycotoxin elimination in polykaryotic industrial fungi W Liu, C An, X Shu, X Meng, Y Yao, J Zhang, F Chen, H Xiang, S Yang, ... ACS Synthetic Biology 9 (8), 2087-2095, 2020 | 50 | 2020 |
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