| Heart disease and stroke statistics—2014 update: a report from the American Heart Association AS Go, D Mozaffarian, VL Roger, EJ Benjamin, JD Berry, MJ Blaha, S Dai, ... circulation 129 (3), e28-e292, 2014 | 73324* | 2014 |
| Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis S Kodama, K Saito, S Tanaka, M Maki, Y Yachi, M Asumi, A Sugawara, ... Jama 301 (19), 2024-2035, 2009 | 3719 | 2009 |
| Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. H Shimano, JD Horton, RE Hammer, I Shimomura, MS Brown, ... The Journal of clinical investigation 98 (7), 1575-1584, 1996 | 998 | 1996 |
| Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. H Shimano, JD Horton, I Shimomura, RE Hammer, MS Brown, ... The Journal of clinical investigation 99 (5), 846-854, 1997 | 978 | 1997 |
| Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis S Kodama, S Tanaka, K Saito, M Shu, Y Sone, F Onitake, E Suzuki, ... Archives of internal medicine 167 (10), 999-1008, 2007 | 976 | 2007 |
| Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. I Shimomura, H Shimano, JD Horton, JL Goldstein, MS Brown The Journal of clinical investigation 99 (5), 838-845, 1997 | 952 | 1997 |
| Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes H Shimano Progress in lipid research 40 (6), 439-452, 2001 | 899 | 2001 |
| SREBP-regulated lipid metabolism: convergent physiology—divergent pathophysiology H Shimano, R Sato Nature Reviews Endocrinology 13 (12), 710-730, 2017 | 851 | 2017 |
| Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. JD Horton, I Shimomura, MS Brown, RE Hammer, JL Goldstein, ... The Journal of clinical investigation 101 (11), 2331-2339, 1998 | 838 | 1998 |
| Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes H Shimano, N Yahagi, M Amemiya-Kudo, AH Hasty, J Osuga, Y Tamura, ... Journal of Biological Chemistry 274 (50), 35832-35839, 1999 | 834 | 1999 |
| Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice JD Horton, Y Bashmakov, I Shimomura, H Shimano Proceedings of the National Academy of Sciences 95 (11), 5987-5992, 1998 | 791 | 1998 |
| TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN M Kato, S Putta, M Wang, H Yuan, L Lanting, I Nair, A Gunn, Y Nakagawa, ... Nature cell biology 11 (7), 881-889, 2009 | 695 | 2009 |
| Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter T Yoshikawa, H Shimano, M Amemiya-Kudo, N Yahagi, AH Hasty, ... Molecular and cellular biology, 2001 | 631 | 2001 |
| Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance T Matsuzaka, H Shimano, N Yahagi, T Kato, A Atsumi, T Yamamoto, ... Nature medicine 13 (10), 1193-1202, 2007 | 594 | 2007 |
| Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. H Shimano, I Shimomura, RE Hammer, J Herz, JL Goldstein, MS Brown, ... The Journal of clinical investigation 100 (8), 2115-2124, 1997 | 558 | 1997 |
| Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements T Yoshikawa, H Shimano, N Yahagi, T Ide, M Amemiya-Kudo, ... Journal of Biological Chemistry 277 (3), 1705-1711, 2002 | 513 | 2002 |
| Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression M Sekiya, N Yahagi, T Matsuzaka, Y Najima, M Nakakuki, R Nagai, ... Hepatology 38 (6), 1529-1539, 2003 | 511 | 2003 |
| Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver I Shimomura, H Shimano, BS Korn, Y Bashmakov, JD Horton Journal of Biological Chemistry 273 (52), 35299-35306, 1998 | 498 | 1998 |
| Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lepob/Lepob mice N Yahagi, H Shimano, AH Hasty, T Matsuzaka, T Ide, T Yoshikawa, ... Journal of Biological Chemistry 277 (22), 19353-19357, 2002 | 467 | 2002 |
| Transcriptional activities of nuclear SREBP-1a,-1c, and-2 to different target promoters of lipogenic and cholesterogenic genes M Amemiya-Kudo, H Shimano, AH Hasty, N Yahagi, T Yoshikawa, ... Journal of lipid research 43 (8), 1220-1235, 2002 | 458 | 2002 |
