Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNF signaling and synaptogenesis in the prefrontal cortex AJ Sales, MV Fogaça, AG Sartim, VS Pereira, G Wegener, FS Guimarães, ... Molecular neurobiology 56 (2), 1070-1081, 2019 | 231 | 2019 |
Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders AC Campos, MV Fogaça, FF Scarante, SRL Joca, AJ Sales, FV Gomes, ... Frontiers in pharmacology 8, 269, 2017 | 180 | 2017 |
Antidepressant‐like effect induced by systemic and intra‐hippocampal administration of DNA methylation inhibitors AJ Sales, C Biojone, MS Terceti, FS Guimarães, MVM Gomes, SRL Joca British journal of pharmacology 164 (6), 1711-1721, 2011 | 156 | 2011 |
Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels AJ Sales, CC Crestani, FS Guimarães, SRL Joca Progress in Neuro-Psychopharmacology and Biological Psychiatry 86, 255-261, 2018 | 131 | 2018 |
Effects of acute and chronic fluoxetine treatments on restraint stress-induced Fos expression C Lino-de-Oliveira, AJ Sales, EA Del Bel, MCL Silveira, FS Guimarães Brain research bulletin 55 (6), 747-754, 2001 | 105 | 2001 |
Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms GP Silote, A Sartim, A Sales, A Eskelund, FS Guimarães, G Wegener, ... Journal of chemical neuroanatomy 98, 104-116, 2019 | 100 | 2019 |
CBD modulates DNA methylation in the prefrontal cortex and hippocampus of mice exposed to forced swim AJ Sales, FS Guimarães, SRL Joca Behavioural brain research 388, 112627, 2020 | 60 | 2020 |
Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels AJ Sales, SRL Joca Acta neuropsychiatrica 28 (1), 11-22, 2016 | 56 | 2016 |
Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus AJ Sales, SRL Joca Behavioural brain research 343, 8-15, 2018 | 43 | 2018 |
Hippocampal nNOS inhibition induces an antidepressant-like effect: involvement of 5HT: 1A: receptors VA Hiroaki-Sato, AJ Sales, C Biojone, SRL Joca Behavioural pharmacology 25 (3), 187-196, 2014 | 32 | 2014 |
Hippocampal mammalian target of rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test AG Sartim, AJ Sales, FS Guimarães, SRL Joca Journal of Psychopharmacology 32 (8), 922-931, 2018 | 28 | 2018 |
Modulation of DNA methylation and gene expression in rodent cortical neuroplasticity pathways exerts rapid antidepressant-like effects AJ Sales, IS Maciel, ACDR Suavinha, SRL Joca Molecular Neurobiology 58, 777-794, 2021 | 23 | 2021 |
DNA methylation in stress and depression: from biomarker to therapeutics AJ Sales, FS Guimarães, SRL Joca Acta Neuropsychiatrica 33 (5), 217-241, 2021 | 21 | 2021 |
Cannabidiol prevents disruptions in sensorimotor gating induced by psychotomimetic drugs that last for 24-h with probable involvement of epigenetic changes in the ventral striatum JFC Pedrazzi, AJ Sales, FS Guimarães, SRL Joca, JAS Crippa, E Del Bel Progress in Neuro-Psychopharmacology and Biological Psychiatry 111, 110352, 2021 | 17 | 2021 |
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala RL Spinieli, RA Cazuza, AJ Sales, ROG Carolino, D Martinez, ... Molecular Pain 18, 17448069221121307, 2022 | 15 | 2022 |
Participation of hippocampal nitric oxide synthase and soluble guanylate cyclase in the modulation of behavioral responses elicited by the rat forced swimming test AJ Sales, VA Hiroaki-Sato, SRL Joca Behavioural Pharmacology 28 (1), 19-29, 2017 | 14 | 2017 |
Regulation of DNA methylation by cannabidiol and its implications for psychiatry: new insights from in vivo and in silico models LB Domingos, NR Silva, AJM Chaves Filho, AJ Sales, A Starnawska, ... Genes 13 (11), 2165, 2022 | 12 | 2022 |
Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders. Front Pharmacol 8: 269 AC Campos, MV Fogaça, FF Scarante, SR Joca, AJ Sales, FV Gomes, ... | 11 | 2017 |
Nitric oxide synthase inhibition counteracts the stress‐induced DNA methyltransferase 3b expression in the hippocampus of rats I de Sousa Maciel, AJ Sales, PC Casarotto, E Castrén, C Biojone, ... European Journal of Neuroscience 55 (9-10), 2421-2434, 2022 | 9 | 2022 |
Putative effects of cannabidiol in depression and synaptic plasticity S Joca, GP Silote, A Sartim, A Sales, F Guimarães, G Wegener The neuroscience of depression, 459-467, 2021 | 8 | 2021 |