Severe COVID-19 is marked by a dysregulated myeloid cell compartment J Schulte-Schrepping, N Reusch, D Paclik, K Baßler, S Schlickeiser, ... Cell 182 (6), 1419-1440. e23, 2020 | 1317 | 2020 |
Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19 JP Bernardes, N Mishra, F Tran, T Bahmer, L Best, JI Blase, D Bordoni, ... Immunity 53 (6), 1296-1314. e9, 2020 | 311 | 2020 |
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 B Krämer, R Knoll, L Bonaguro, M ToVinh, J Raabe, ... Immunity 54 (11), 2650-2669. e14, 2021 | 188 | 2021 |
Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research F Hufsky, K Lamkiewicz, A Almeida, A Aouacheria, C Arighi, A Bateman, ... Briefings in bioinformatics 22 (2), 642-663, 2021 | 149 | 2021 |
Trends in respiratory virus circulation following COVID-19-targeted nonpharmaceutical interventions in Germany, January-September 2020: Analysis of national surveillance data DY Oh, S Buda, B Biere, J Reiche, F Schlosser, S Duwe, M Wedde, ... The Lancet Regional Health–Europe 6, 2021 | 129 | 2021 |
Mutational interference mapping experiment (MIME) for studying RNA structure and function RP Smyth, L Despons, G Huili, S Bernacchi, M Hijnen, J Mak, F Jossinet, ... Nature methods 12 (9), 866-872, 2015 | 80 | 2015 |
Pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against HIV-1 infection S Duwal, C Schütte, M von Kleist PloS one 7 (7), e40382, 2012 | 77 | 2012 |
Local c-di-GMP signaling in the control of synthesis of the E. coli biofilm exopolysaccharide pEtN-cellulose AM Richter, A Possling, N Malysheva, KP Yousef, S Herbst, M von Kleist, ... Journal of molecular biology 432 (16), 4576-4595, 2020 | 69 | 2020 |
Drug-class specific impact of antivirals on the reproductive capacity of HIV M von Kleist, S Menz, W Huisinga PLoS computational biology 6 (3), e1000720, 2010 | 56 | 2010 |
Serial synapse formation through filopodial competition for synaptic seeding factors MN Özel, A Kulkarni, A Hasan, J Brummer, M Moldenhauer, IM Daumann, ... Developmental cell 50 (4), 447-461. e8, 2019 | 43 | 2019 |
HIV-1 polymerase inhibition by nucleoside analogs: cellular-and kinetic parameters of efficacy, susceptibility and resistance selection M von Kleist, P Metzner, R Marquet, C Schütte PLoS Computational Biology 8 (1), e1002359, 2012 | 42 | 2012 |
Physiologically based pharmacokinetic modelling: a sub-compartmentalized model of tissue distribution M von Kleist, W Huisinga Journal of pharmacokinetics and pharmacodynamics 34, 789-806, 2007 | 42 | 2007 |
HIV quasispecies dynamics during pro-active treatment switching: impact on multi-drug resistance and resistance archiving in latent reservoirs M von Kleist, S Menz, H Stocker, K Arasteh, C Schütte, W Huisinga PloS one 6 (3), e18204, 2011 | 40 | 2011 |
Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring FR Kiral, GA Linneweber, T Mathejczyk, SV Georgiev, MF Wernet, ... Nature communications 11 (1), 1325, 2020 | 38 | 2020 |
Analysis of long non-coding RNA and mRNA expression in bovine macrophages brings up novel aspects of Mycobacterium avium subspecies paratuberculosis infections P Gupta, S Peter, M Jung, A Lewin, G Hemmrich-Stanisak, A Franke, ... Scientific reports 9 (1), 1571, 2019 | 34 | 2019 |
In cell mutational interference mapping experiment (in cell MIME) identifies the 5′ polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging RP Smyth, MR Smith, AC Jousset, L Despons, G Laumond, T Decoville, ... Nucleic acids research 46 (9), e57-e57, 2018 | 34 | 2018 |
Secondary data for global health digitalisation AF Näher, CN Vorisek, SAI Klopfenstein, M Lehne, S Thun, S Alsalamah, ... The Lancet Digital Health 5 (2), e93-e101, 2023 | 33 | 2023 |
Maßnahmen zur Bewältigung der COVID-19-Pandemie in Deutschland: nichtpharmakologische und pharmakologische Ansätze U Grote, M Arvand, S Brinkwirth, M Brunke, U Buchholz, T Eckmanns, ... Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 64 (4), 435, 2021 | 30 | 2021 |
Top-down and bottom-up modeling in system pharmacology to understand clinical efficacy: An example with NRTIs of HIV-1 S Duwal, M von Kleist European Journal of Pharmaceutical Sciences 94, 72-83, 2016 | 29 | 2016 |
Virus load kinetics and resistance development during oseltamivir treatment in infants and children infected with Influenza A (H1N1) 2009 and Influenza B viruses B Rath, M von Kleist, F Tief, K Karsch, E Tuerk, S Muehlhans, F Louis, ... The Pediatric infectious disease journal 31 (9), 899-905, 2012 | 29 | 2012 |