Isomerization and ring-closing metathesis for the synthesis of 6-, 7-and 8-membered benzo-and pyrido-fused N, N-, N, O-and N, S-heterocycles WAL van Otterlo, GL Morgans, SD Khanye, BAA Aderibigbe, JP Michael, ... Tetrahedron letters 45 (50), 9171-9175, 2004 | 88 | 2004 |
Synthesis and in vitro evaluation of gold (I) thiosemicarbazone complexes for antimalarial activity SD Khanye, GS Smith, C Lategan, PJ Smith, J Gut, PJ Rosenthal, ... Journal of inorganic biochemistry 104 (10), 1079-1083, 2010 | 81 | 2010 |
Synthesis and in vitro antimalarial and antitubercular activity of gold (III) complexes containing thiosemicarbazone ligands SD Khanye, B Wan, SG Franzblau, J Gut, PJ Rosenthal, GS Smith, ... Journal of Organometallic Chemistry 696 (21), 3392-3396, 2011 | 60 | 2011 |
Ferrocenylthiosemicarbazones conjugated to a poly (propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity SD Khanye, J Gut, PJ Rosenthal, K Chibale, GS Smith Journal of Organometallic Chemistry 696 (21), 3296-3300, 2011 | 59 | 2011 |
Application of the Morita-Baylis-Hillman reaction in the synthesis of 3-[(N-cycloalkylbenzamido) methyl]-2-quinolones as potential HIV-1 integrase inhibitors KC Sekgota, S Majumder, M Isaacs, D Mnkandhla, HC Hoppe, ... Bioorganic chemistry 75, 310-316, 2017 | 51 | 2017 |
Synthesis of unsaturated 1, 4-heteroatom-containing benzo-fused heterocycles using a sequential isomerization–ring-closing metathesis strategy GL Morgans, EL Ngidi, LG Madeley, SD Khanye, JP Michael, ... Tetrahedron 65 (51), 10650-10659, 2009 | 40 | 2009 |
Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity M Mbaba, AN Mabhula, N Boel, AL Edkins, M Isaacs, HC Hoppe, ... Journal of inorganic biochemistry 172, 88-93, 2017 | 37 | 2017 |
Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition M Mbaba, JA de la Mare, JN Sterrenberg, D Kajewole, S Maharaj, ... JBIC Journal of Biological Inorganic Chemistry 24, 139-149, 2019 | 28 | 2019 |
Quinolone-isoniazid hybrids: Synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation RM Beteck, R Seldon, A Jordaan, DF Warner, HC Hoppe, D Laming, ... Medchemcomm 10 (2), 326-331, 2019 | 28 | 2019 |
Indolyl-3-ethanone-α-thioethers: a promising new class of non-toxic antimalarial agents AL Svogie, M Isaacs, HC Hoppe, SD Khanye, CGL Veale European Journal of Medicinal Chemistry 114, 79-88, 2016 | 26 | 2016 |
Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis Journal of Medicinal Chemistry 61 (24), 11327–11340, 2018 | 25 | 2018 |
Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1, 3-benzoxazine derivatives M Mbaba, LMK Dingle, D Cash, JA de la Mare, D Laming, D Taylor, ... European Journal of Medicinal Chemistry 187, 111924, 2020 | 23 | 2020 |
Cinnamoyl-oxaborole amides: Synthesis and their in vitro biological activity M Gumbo, RM Beteck, T Mandizvo, R Seldon, DF Warner, HC Hoppe, ... Molecules 23 (8), 2038, 2018 | 21 | 2018 |
New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis RM Beteck, R Seldon, A Jordaan, DF Warner, HC Hoppe, D Laming, ... Molecules 24 (9), 1740, 2019 | 19 | 2019 |
New thiazolidine‐2, 4‐dione derivatives combined with organometallic ferrocene: Synthesis, structure and antiparasitic activity OO Oderinlo, M Tukulula, M Isaacs, HC Hoppe, D Taylor, VJ Smith, ... Applied Organometallic Chemistry 32 (7), e4385, 2018 | 19 | 2018 |
Coumarin-Annulated Ferrocenyl 1,3-Oxazine Derivatives Possessing In Vitro Antimalarial and Antitrypanosomal Potency SDK M Mbaba, LMK Dingle, AI Zulu, D Laming, T Swart, J.-A de la Mare, HC ... Molecules 26 (5), 1333, 2021 | 18 | 2021 |
Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic arylpyrrole-based chalcone derivatives AI Zulu, OO Oderinlo, C Kruger, M Isaacs, HC Hoppe, VJ Smith, ... Molecules 25 (7), 1668, 2020 | 17 | 2020 |
A ring-closing metathesis approach to eight-membered benzannelated scaffolds and subsequent internal alkene isomerizations A Taher, BA Aderibigbe, GL Morgans, LG Madeley, SD Khanye, ... Tetrahedron 69 (8), 2038-2047, 2013 | 17 | 2013 |
Gold (i) derived thiosemicarbazone complexes with rare halogen–halogen interaction–reduction of [Au (damp-C 1, N) Cl 2] SD Khanye, NB Báthori, GS Smith, K Chibale Dalton Transactions 39 (10), 2697-2700, 2010 | 17 | 2010 |
Anti-trypanosomal and antimalarial properties of tetralone derivatives and structurally related benzocycloalkanones RM Beteck, LJ Legoabe, M Isaacs, SD Khanye, D Laming, HC Hoppe Medicina 55 (5), 206, 2019 | 15 | 2019 |