| Hydroxyl groups in synthetic and natural-product-derived therapeutics: a perspective on a common functional group J Cramer, CP Sager, B Ernst Journal of medicinal chemistry 62 (20), 8915-8930, 2019 | 135 | 2019 |
| Rational design of thermodynamic and kinetic binding profiles by optimizing surface water networks coating protein-bound ligands SG Krimmer, J Cramer, M Betz, V Fridh, R Karlsson, A Heine, G Klebe Journal of medicinal chemistry 59 (23), 10530-10548, 2016 | 77 | 2016 |
| Paying the price of desolvation in solvent-exposed protein pockets: impact of distal solubilizing groups on affinity and binding thermodynamics in a series of thermolysin … J Cramer, SG Krimmer, A Heine, G Klebe Journal of Medicinal Chemistry 60 (13), 5791-5799, 2017 | 36 | 2017 |
| Sweet drugs for bad bugs: a glycomimetic strategy against the DC-SIGN-mediated dissemination of SARS-CoV-2 J Cramer, A Lakkaichi, B Aliu, RP Jakob, S Klein, I Cattaneo, X Jiang, ... Journal of the American Chemical Society 143 (42), 17465-17478, 2021 | 33 | 2021 |
| Improvement of Aglycone π‐Stacking Yields Nanomolar to Sub‐nanomolar FimH Antagonists W Schönemann, J Cramer, T Mühlethaler, B Fiege, M Silbermann, ... ChemMedChem 14 (7), 749-757, 2019 | 31 | 2019 |
| How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S1′ Pocket of Thermolysin SG Krimmer, J Cramer, J Schiebel, A Heine, G Klebe Journal of the American Chemical Society 139 (30), 10419-10431, 2017 | 27 | 2017 |
| Poly‐l‐lysine Glycoconjugates Inhibit DC‐SIGN‐mediated Attachment of Pandemic Viruses J Cramer, B Aliu, X Jiang, T Sharpe, L Pang, A Hadorn, S Rabbani, ... ChemMedChem 16 (15), 2345-2353, 2021 | 20 | 2021 |
| A Potent Mimetic of the Siglec‐8 Ligand 6’‐Sulfo‐Sialyl Lewisx BS Kroezen, G Conti, B Girardi, J Cramer, X Jiang, S Rabbani, J Müller, ... ChemMedChem 15 (18), 1706-1719, 2020 | 18 | 2020 |
| Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN J Cramer RSC Medicinal Chemistry 12 (12), 1985-2000, 2021 | 16 | 2021 |
| A False‐Positive Screening Hit in Fragment‐Based Lead Discovery: Watch out for the Red Herring J Cramer, J Schiebel, T Wulsdorf, K Grohe, EE Najbauer, FR Ehrmann, ... Angewandte Chemie International Edition 56 (7), 1908-1913, 2017 | 16 | 2017 |
| Elucidating the origin of long residence time binding for inhibitors of the metalloprotease thermolysin J Cramer, SG Krimmer, V Fridh, T Wulsdorf, R Karlsson, A Heine, G Klebe ACS Chemical Biology 12 (1), 225-233, 2017 | 15 | 2017 |
| Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding J Cramer, X Jiang, W Schönemann, M Silbermann, P Zihlmann, S Siegrist, ... RSC chemical biology 1 (4), 281-287, 2020 | 13 | 2020 |
| Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia** K Lal, R Bermeo, J Cramer, F Vasile, B Ernst, A Imberty, A Bernardi, ... Chemistry–A European Journal 27 (40), 10341-10348, 2021 | 6 | 2021 |
| An allyl protection and improved purification strategy enables the synthesis of functionalized phosphonamidate peptides J Cramer, G Klebe Synthesis 49 (08), 1857-1866, 2017 | 6 | 2017 |
| Sialic acid derivatives inhibit SiaT transporters and delay bacterial growth T Bozzola, M Scalise, CU Larsson, MC Newton-Vesty, C Rovegno, A Mitra, ... ACS Chemical Biology 17 (7), 1890-1900, 2022 | 5 | 2022 |
| Synthesis and Binding Mode Predictions of Novel Siglec-7 Ligands M Frank, E Kuhfeldt, J Cramer, C Watzl, H Prescher Journal of Medicinal Chemistry 66 (20), 14315-14334, 2023 | 2 | 2023 |
| The role of glycosylation patterns of viral glycoproteins and cell entry receptors in arenavirus infection. M Gorzkiewicz, J Cramer, HC Xu, PA Lang Biomedicine & Pharmacotherapy 166, 115196, 2023 | 2 | 2023 |
| Thermodynamics-Guided Design Reveals a Cooperative Hydrogen Bond in DC-SIGN-targeted Glycomimetics DD Nemli, X Jiang, RP Jakob, LM Gloder, O Schwardt, S Rabbani, ... Journal of Medicinal Chemistry, 2024 | 1 | 2024 |
| Falsch‐positiver Treffer im Fragment‐basierten Wirkstoffdesign: Lass Dich nicht auf die falsche Fährte locken! J Cramer, J Schiebel, T Wulsdorf, K Grohe, EE Najbauer, FR Ehrmann, ... Angewandte Chemie 129 (7), 1934-1940, 2017 | 1 | 2017 |
| Analogues of the pan-selectin antagonist rivipansel (GMI-1070) B Wagner, M Smieško, RP Jakob, T Mühlethaler, J Cramer, T Maier, ... European Journal of Medicinal Chemistry 272, 116455, 2024 | | 2024 |
