Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2 D Héja, A Kocsis, J Dobó, K Szilágyi, R Szász, P Závodszky, G Pál, P Gál Proceedings of the National Academy of Sciences 109 (26), 10498-10503, 2012 | 262 | 2012 |
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and-2 are essential for lectin pathway activation and reveal structural … D Héja, V Harmat, K Fodor, M Wilmanns, J Dobó, KA Kékesi, P Závodszky, ... Journal of Biological Chemistry 287 (24), 20290-20300, 2012 | 101 | 2012 |
Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation … M Megyeri, V Harmat, B Major, Á Végh, J Balczer, D Héja, K Szilágyi, ... Journal of Biological Chemistry 288 (13), 8922-8934, 2013 | 81 | 2013 |
Dynamic regulation of B cell complement signaling is integral to germinal center responses A Cumpelik, D Heja, Y Hu, G Varano, F Ordikhani, MP Roberto, Z He, ... Nature immunology 22 (6), 757-768, 2021 | 49 | 2021 |
Design and testing of a humanized porcine donor for xenotransplantation RP Anand, JV Layer, D Heja, T Hirose, G Lassiter, DJ Firl, VB Paragas, ... Nature 622 (7982), 393-401, 2023 | 43 | 2023 |
High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4′ acidic residues A Szabó, D Héja, D Szakács, K Zboray, KA Kékesi, ES Radisky, ... Journal of Biological Chemistry 286 (25), 22535-22545, 2011 | 37 | 2011 |
Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum ZA Nagy, D Szakács, E Boros, D Héja, E Vígh, N Sándor, M Józsi, ... PLoS Pathogens 15 (12), e1008232, 2019 | 33 | 2019 |
Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation F Fueyo-González, M McGinty, M Ningoo, L Anderson, C Cantarelli, ... Immunity 55 (3), 459-474. e7, 2022 | 24 | 2022 |
Overlapping specificity of duplicated human pancreatic elastase 3 isoforms and archetypal porcine elastase 1 provides clues to evolution of digestive enzymes E Boros, A Szabó, K Zboray, D Héja, G Pál, M Sahin-Tóth Journal of Biological Chemistry 292 (7), 2690-2702, 2017 | 17 | 2017 |
Directed evolution of canonical loops and their swapping between unrelated serine proteinase inhibitors disprove the interscaffolding additivity model E Boros, F Sebák, D Héja, D Szakács, K Zboray, G Schlosser, A Micsonai, ... Journal of molecular biology 431 (3), 557-575, 2019 | 16 | 2019 |
Mannan-binding lectin deficiency attenuates acute GvHD in pediatric hematopoietic stem cell transplantation S Heitzeneder, P Zeitlhofer, U Pötschger, E Nowak, MG Seidel, M Hölzl, ... Bone Marrow Transplantation 50 (8), 1127-1129, 2015 | 5 | 2015 |
Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation ZA Nagy, D Héja, D Bencze, B Kiss, E Boros, D Szakács, K Fodor, ... Journal of Biological Chemistry 298 (6), 2022 | 4 | 2022 |
Mannan-Binding Lectin Promotes Murine Graft-versus-Host Disease by Amplifying Lipopolysaccharide-Initiated Inflammation D Heja, D Zhao, E Cody, A Cumpelik, PC Lim, M Prado-Acosta, L Palma, ... Transplantation and cellular therapy 28 (8), 472. e1-472. e11, 2022 | 1 | 2022 |
412.1: Long-term (2 years) survival of porcine to nonhuman primate life-sustaining kidney xenotransplantation A Karadagi, T Hirose, IA Rosales, G Lassiter, T Tomosugi, R Otsuka, D Firl, ... Transplantation 107 (10S2), 173, 2023 | | 2023 |
216.6: Design and creation of a clinically compatible porcine donor for xenotransplantation W Qin, RP Anand, VB Paragas, JV Layer, A Akkad, M Pandelakis, S Yin, ... Transplantation 107 (10S2), 53, 2023 | | 2023 |
202.1: Pancreatic islets from genetically altered porcine donors are metabolically competent and cure diabetes in mice post xenotransplantation L Kalekar, PN Perrat, DM Grosh, WFL Rodriguez, OJ Pearce, ... Transplantation 107 (10S2), 39, 2023 | | 2023 |
237.6: Amplification-free activation of primate complement by porcine triple-knockout cells is driven by the classical pathway D Heja, N Esch, WT Serkin, S Harken, JV Layer, W Qin, ME Youd Transplantation 107 (10S2), 76, 2023 | | 2023 |
Correction: Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation ZA Nagy, D Héja, D Bencze, B Kiss, E Boros, D Szakács, K Fodor, ... Journal of Biological Chemistry 299 (1), 2023 | | 2023 |
Different roles of protease binding sites of ecotin in inhibition of complement proteases MASP-1, 2 and 3 V Harmat, ZA Nagy, D Héja, D Bencze, B Kiss, E Boros, D Szakács, ... Acta Crystallographica Section A: Foundations and Advances 78, a382-a382, 2022 | | 2022 |
HOMODIMER STRUCTURE OF ECOTIN IS ESSENTIAL FOR INHIBITING ALL THREE HUMAN MASP ENZYMES VIA AN INTERPLAY OF THE PRIMARY AND SECONDARY BINDING SITES ZA Nagy, D Bencze, D Szakacs, E Boros, E Vigh, J Dobo, D Heja, K Fodor, ... MOLECULAR IMMUNOLOGY 114, 471-471, 2019 | | 2019 |