G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation C Sina, O Gavrilova, M Förster, A Till, S Derer, F Hildebrand, B Raabe, ... The Journal of Immunology 183 (11), 7514-7522, 2009 | 434 | 2009 |
Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase KC Qian, L Wang, ER Hickey, J Studts, K Barringer, C Peng, A Kronkaitis, ... Journal of Biological Chemistry 280 (7), 6130-6137, 2005 | 323 | 2005 |
IKKα, IKKβ, and NEMO/IKKγ are each required for the NF-κB-mediated inflammatory response program X Li, PE Massa, A Hanidu, GW Peet, P Aro, A Savitt, S Mische, J Li, ... Journal of Biological Chemistry 277 (47), 45129-45140, 2002 | 297 | 2002 |
Proteomic identification of proteins conjugated to ISG15 in mouse and human cells NV Giannakopoulos, JK Luo, V Papov, W Zou, DJ Lenschow, BS Jacobs, ... Biochemical and biophysical research communications 336 (2), 496-506, 2005 | 268 | 2005 |
Novel NEMO/IκB kinase and NF-κB target genes at the pre-B to immature B cell transition J Li, GW Peet, D Balzarano, X Li, P Massa, RW Barton, KB Marcu Journal of Biological Chemistry 276 (21), 18579-18590, 2001 | 206 | 2001 |
Interferon-γ represses M2 gene expression in human macrophages by disassembling enhancers bound by the transcription factor MAF K Kang, SH Park, J Chen, Y Qiao, E Giannopoulou, K Berg, A Hanidu, J Li, ... Immunity 47 (2), 235-250. e4, 2017 | 175 | 2017 |
The IκB kinase (IKK) complex is tripartite and contains IKKγ but not IKAP as a regular component D Krappmann, EN Hatada, S Tegethoff, J Li, A Klippel, K Giese, ... Journal of Biological Chemistry 275 (38), 29779-29787, 2000 | 160 | 2000 |
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9 LX Heinz, JE Lee, U Kapoor, F Kartnig, V Sedlyarov, K Papakostas, ... Nature 581 (7808), 316-322, 2020 | 153 | 2020 |
Epstein‐Barr virus‐induced gene 3 negatively regulates IL‐17, IL‐22 and RORγt J Yang, M Yang, TM Htut, X Ouyang, A Hanidu, X Li, R Sellati, H Jiang, ... European journal of immunology 38 (5), 1204-1214, 2008 | 144 | 2008 |
Inhibitor of NF-κB kinases α and β are both essential for high mobility group box 1-mediated chemotaxis M Penzo, R Molteni, T Suda, S Samaniego, A Raucci, DM Habiel, F Miller, ... The Journal of Immunology 184 (8), 4497-4509, 2010 | 130 | 2010 |
IκB kinases α and β show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin GW Peet, J Li Journal of Biological Chemistry 274 (46), 32655-32661, 1999 | 124 | 1999 |
CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts W Cui, E Cuartas, J Ke, Q Zhang, HB Einarsson, JD Sedgwick, J Li, ... Proceedings of the National Academy of Sciences 104 (36), 14436-14441, 2007 | 104 | 2007 |
ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin W Zou, V Papov, O Malakhova, KI Kim, C Dao, J Li, DE Zhang Biochemical and biophysical research communications 336 (1), 61-68, 2005 | 99 | 2005 |
Recombinant IκB kinases α and β are direct kinases of IκBα J Li, GW Peet, SS Pullen, J Schembri-King, TC Warren, KB Marcu, ... Journal of Biological Chemistry 273 (46), 30736-30741, 1998 | 97 | 1998 |
Pim kinase substrate identification and specificity C Peng, A Knebel, NA Morrice, X Li, K Barringer, J Li, S Jakes, ... The journal of biochemistry 141 (3), 353-362, 2007 | 93 | 2007 |
Differential requirements for IKKα and IKKβ in the differentiation of primary human osteoarthritic chondrocytes E Olivotto, RM Borzi, R Vitellozzi, S Pagani, A Facchini, M Battistelli, ... Arthritis & Rheumatism 58 (1), 227-239, 2008 | 89 | 2008 |
Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode K Qian, L Wang, CL Cywin, BT Farmer, E Hickey, C Homon, S Jakes, ... Journal of medicinal chemistry 52 (7), 1814-1827, 2009 | 81 | 2009 |
Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β X Cai, S Srivastava, Y Sun, Z Li, H Wu, L Zuvela-Jelaska, J Li, ... Proceedings of the National Academy of Sciences 108 (50), 20072-20077, 2011 | 72 | 2011 |
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors A Heim-Riether, SJ Taylor, S Liang, DA Gao, Z Xiong, EM August, ... Bioorganic & medicinal chemistry letters 19 (18), 5321-5324, 2009 | 56 | 2009 |
Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease H Kang, A Kerloc’h, M Rotival, X Xu, Q Zhang, Z D’Souza, M Kim, ... Cell reports 8 (4), 1210-1224, 2014 | 54 | 2014 |