Elafibranor modulates ileal macrophage polarization to restore intestinal integrity in NASH: Potential crosstalk between ileal IL-10/STAT3 and hepatic TLR4/NF-κB axes AN Hakeem, MM Kamal, RA Tawfiq, BA Abdelrahman, OA Hammam, ... Biomedicine & Pharmacotherapy 157, 114050, 2023 | 7 | 2023 |
Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells AN Hakeem, DM El-Kersh, O Hammam, A Elhosseiny, A Zaki, K Kamel, ... Scientific Reports 14 (1), 18181, 2024 | | 2024 |
Harnessing adrenergic blockade in stress-promoted TNBC in vitro and solid tumor in vivo: disrupting HIF-1α and GSK-3β/β-catenin driven resistance to doxorubicin Y Attia, A Hakeem, R Samir, A Mohammed, A Elsayed, A Khallaf, E Essam, ... Frontiers in Pharmacology 15, 1362675, 2024 | | 2024 |
THU-255 Calcitriol modulates intestinal AMPK/SIRT1 signaling towards alleviating compromised barrier integrity in MASH: a potential autophagy-dependent role A Hakeem, B Abdelrahman, O Hammam, M Khattab, A El-Khatib, Y Attia Journal of Hepatology 80, S583, 2024 | | 2024 |
Unravelling an autophagy-dependent role of vitamin D in preserving gut integrity in experimental NASH A Hakeem, B Alaa, O Hammam, M Khattab, A El-Khatib, Y Attia Journal of Hepatology 78, S795, 2023 | | 2023 |
Unravelling an autophagy-dependent role of vitamin D in preserving gut integrity in experimental NASH YM Attia, A Hakeem, O Hammam, A El-Khatib, M Khattab, B Abdelrahman | | 2023 |
Elafibranor, a PPAR alpha/delta agonist, impedes bacterial translocation in NASH via modulation of M1/M2 macrophage polarisation A Hakeem, Y Attia, O Hammam, A El-Khatib BRITISH JOURNAL OF PHARMACOLOGY 178 (24), 4973-4974, 2021 | | 2021 |
Role of piperine in chemoresistance of triple-negative breast cancer: Potential modulation of PI3K/Akt/mTOR pathway AA Fattah, A Zaki, K Kamel, L Yasser, M Barsom, MA Ahmed, M Gamal, ... BRITISH JOURNAL OF PHARMACOLOGY 177 (11), 2539-2540, 2020 | | 2020 |