SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing Z Zhang, F Lotti, K Dittmar, I Younis, L Wan, M Kasim, G Dreyfuss Cell 133 (4), 585-600, 2008 | 714 | 2008 |
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation D Kaida, MG Berg, I Younis, M Kasim, LN Singh, L Wan, G Dreyfuss nature 468 (7324), 664-668, 2010 | 681 | 2010 |
U1 snRNP determines mRNA length and regulates isoform expression MG Berg, LN Singh, I Younis, Q Liu, AM Pinto, D Kaida, Z Zhang, S Cho, ... Cell 150 (1), 53-64, 2012 | 500 | 2012 |
The cancer spliceome: reprograming of alternative splicing in cancer E El Marabti, I Younis Frontiers in molecular biosciences 5, 80, 2018 | 232 | 2018 |
U1 snRNP regulates cancer cell migration and invasion in vitro JM Oh, CC Venters, C Di, AM Pinto, L Wan, I Younis, Z Cai, C Arai, BR So, ... Nature communications 11 (1), 1, 2020 | 228 | 2020 |
Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1 J Arnold, B Yamamoto, M Li, AJ Phipps, I Younis, MD Lairmore, PL Green Blood 107 (10), 3976-3982, 2006 | 223 | 2006 |
PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs MD Diem, CC Chan, I Younis, G Dreyfuss Nature structural & molecular biology 14 (12), 1173-1179, 2007 | 139 | 2007 |
Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing I Younis, M Berg, D Kaida, K Dittmar, C Wang, G Dreyfuss Molecular and cellular biology 30 (7), 1718-1728, 2010 | 136 | 2010 |
U1 snRNP telescripting regulates a size–function-stratified human genome JM Oh, C Di, CC Venters, J Guo, C Arai, BR So, AM Pinto, Z Zhang, L Wan, ... Nature structural & molecular biology 24 (11), 993-999, 2017 | 115 | 2017 |
The human T-cell leukemia virus Rex protein I Younis, PL Green Frontiers in bioscience: a journal and virtual library 10, 431, 2005 | 109 | 2005 |
Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA I Younis, K Dittmar, W Wang, SW Foley, MG Berg, KY Hu, Z Wei, L Wan, ... Elife 2, e00780, 2013 | 98 | 2013 |
Repression of human T-cell leukemia virus type 1 and type 2 replication by a viral mRNA-encoded posttranscriptional regulator I Younis, L Khair, M Dundr, MD Lairmore, G Franchini, PL Green Journal of virology 78 (20), 11077-11083, 2004 | 96 | 2004 |
A U1 snRNP–specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange BR So, L Wan, Z Zhang, P Li, E Babiash, J Duan, I Younis, G Dreyfuss Nature structural & molecular biology 23 (3), 225-230, 2016 | 82 | 2016 |
A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis MG Berg, L Wan, I Younis, MD Diem, M Soo, C Wang, G Dreyfuss Molecular and Cellular Biology, 2012 | 48 | 2012 |
Keratinocytes derived from patient-specific induced pluripotent stem cells recapitulate the genetic signature of psoriasis disease G Ali, AK Elsayed, M Nandakumar, M Bashir, I Younis, Y Abu Aqel, ... Stem cells and development 29 (7), 383-400, 2020 | 37 | 2020 |
Functional domain structure of human T-cell leukemia virus type 2 rex M Narayan, I Younis, DM D'Agostino, PL Green Journal of virology 77 (23), 12829-12840, 2003 | 37 | 2003 |
Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo B Yamamoto, M Li, M Kesic, I Younis, MD Lairmore, PL Green Retrovirology 5, 1-11, 2008 | 29 | 2008 |
Human T-cell leukemia virus open reading frame II encodes a posttranscriptional repressor that is recruited at the level of transcription I Younis, K Boris-Lawrie, PL Green Journal of virology 80 (1), 181-191, 2006 | 25 | 2006 |
PDX1−/NKX6.1+ progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells B Memon, I Younis, F Abubaker, EM Abdelalim Diabetes/Metabolism Research and Reviews 37 (5), e3400, 2021 | 24 | 2021 |
Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency AK Elsayed, I Younis, G Ali, K Hussain, EM Abdelalim Cell Death & Disease 12 (1), 103, 2021 | 24 | 2021 |