VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics AW Lund, FV Duraes, S Hirosue, VR Raghavan, C Nembrini, SN Thomas, ... Cell reports 1 (3), 191-199, 2012 | 331 | 2012 |
Antigen delivery to dendritic cells by poly (propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation S Hirosue, IC Kourtis, AJ van der Vlies, JA Hubbell, MA Swartz Vaccine 28 (50), 7897-7906, 2010 | 262 | 2010 |
Engineering approaches to immunotherapy MA Swartz, S Hirosue, JA Hubbell Science translational medicine 4 (148), 148rv9-148rv9, 2012 | 244 | 2012 |
Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells S Hirosue, E Vokali, VR Raghavan, M Rincon-Restrepo, AW Lund, ... The Journal of Immunology 192 (11), 5002-5011, 2014 | 212 | 2014 |
Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity DS Wilson, S Hirosue, MM Raczy, L Bonilla-Ramirez, L Jeanbart, R Wang, ... Nature materials 18 (2), 175-185, 2019 | 207 | 2019 |
Primary human and rat β-cells release the intracellular autoantigens GAD65, IA-2, and proinsulin in exosomes together with cytokine-induced enhancers of immunity C Cianciaruso, EA Phelps, M Pasquier, R Hamelin, D Demurtas, ... Diabetes 66 (2), 460-473, 2017 | 172 | 2017 |
Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses DJ Dowling, EA Scott, A Scheid, I Bergelson, S Joshi, C Pietrasanta, ... Journal of Allergy and Clinical Immunology 140 (5), 1339-1350, 2017 | 157 | 2017 |
Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in mice IC Kourtis, S Hirosue, A De Titta, S Kontos, T Stegmann, JA Hubbell, ... PloS one 8 (4), e61646, 2013 | 144 | 2013 |
Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids S Hirosue, BG Mueller, RS Langer, RC Mulligan US Patent 6,254,890, 2001 | 119 | 2001 |
Plasmid DNA encapsulation and release from solvent diffusion nanospheres S Hirosue, BG Müller, RC Mulligan, R Langer Journal of Controlled Release 70 (1-2), 231-242, 2001 | 99 | 2001 |
Modes of antigen presentation by lymph node stromal cells and their immunological implications S Hirosue, J Dubrot Frontiers in immunology 6, 446, 2015 | 77 | 2015 |
Toward responsive architectures P Beesley, S Hirosue, J Ruxton Responsive Architectures: Subtle Technologies. Eds. Philip Beesley, Sachiko …, 2006 | 66 | 2006 |
Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes DS Wilson, M Damo, S Hirosue, MM Raczy, K Brünggel, G Diaceri, ... Nature biomedical engineering 3 (10), 817-829, 2019 | 61 | 2019 |
Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions E Vokali, SS Yu, S Hirosue, M Rinçon-Restrepo, F V. Duraes, S Scherer, ... Nature communications 11 (1), 538, 2020 | 60 | 2020 |
Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses M Rincon-Restrepo, A Mayer, S Hauert, DK Bonner, EA Phelps, ... Biomaterials 132, 48-58, 2017 | 58 | 2017 |
Effect of inhibition of dynein function and microtubule-altering drugs on AAV2 transduction S Hirosue, K Senn, N Clément, M Nonnenmacher, L Gigout, RM Linden, ... Virology 367 (1), 10-18, 2007 | 51 | 2007 |
Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization JK Eby, KY Dane, CP O’Neil, S Hirosue, MA Swartz, JA Hubbell Acta biomaterialia 8 (9), 3210-3217, 2012 | 44 | 2012 |
Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein C Galan-Navarro, M Rincon-Restrepo, G Zimmer, EO Saphire, JA Hubbell, ... Virology 512, 161-171, 2017 | 29 | 2017 |
Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1 SM Caucheteux, JP Mitchell, MO Ivory, S Hirosue, S Hakobyan, G Dolton, ... Journal of Investigative Dermatology 136 (6), 1172-1181, 2016 | 24 | 2016 |
pH-Dependent lytic peptides discovered by phage display S Hirosue, T Weber Biochemistry 45 (20), 6476-6487, 2006 | 18 | 2006 |